Patents by Inventor Jerry L. Adams

Jerry L. Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds
    Patent number: 5559137
    Abstract: This invention relates to the novel pyrazole compounds of Formula (I), and pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable diluent or carrier.This invention also relates to a method of inhibiting cytokines by a compound of Formula (I) and the treatment of cytokine mediated diseases, in mammals, by administration of said compound.
    Type: Grant
    Filed: May 16, 1994
    Date of Patent: September 24, 1996
    Assignee: SmithKline Beecham Corp.
    Inventors: Jerry L. Adams, Timothy G. Gallagher, Susan M. Thompson
  • Anti-inflammatory compounds
    Patent number: 5545669
    Abstract: This invention relates to the novel compounds and pharmaceutical compositions of Formula (I).This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I).
    Type: Grant
    Filed: June 2, 1994
    Date of Patent: August 13, 1996
    Inventors: Jerry L. Adams, Ralph F. Hall, Dennis Lee, Ruth J. Mayer, George L. Seibel
  • Anti-inflammatory compounds
    Patent number: 5496855
    Abstract: This invention relates to the novel compounds and pharmaceutical compositions of Formulas (I) and (II).This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I) or (II).
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: March 5, 1996
    Assignee: SmithKline Beecham Corp.
    Inventors: Jerry L. Adams, Ravi S. Garigipati, Margaret E. Sorenson, James D. Winkler
  • Anti-inflammatory compounds
    Patent number: 5447957
    Abstract: This invention relates to the novel compounds and pharmaceutical compositions of Formula (I).This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I).
    Type: Grant
    Filed: June 2, 1994
    Date of Patent: September 5, 1995
    Assignee: SmithKline Beecham Corp.
    Inventors: Jerry L. Adams, Ralph F. Hall, George L. Seibel
  • Pyrrolo [1,2-a] imidazole and imidazo [1,2a] pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
    Patent number: 5145858
    Abstract: Compounds comprising pyridyl and phenyl substituted pyrrolo[1,2-a]imidazole derivatives and pyridyl and phenyl substituted imidazo[1,2-a]pyridine derivatives, pharmaceutical compositions containing said compounds, and their use as 5-lipoxygenase pathway inhibitors.
    Type: Grant
    Filed: December 26, 1991
    Date of Patent: September 8, 1992
    Assignee: SmithKline Beecham Corp.
    Inventors: Jerry L. Adams, Paul E. Bender, John G. Gleason, Nabil Hanna, John F. Newton, Jr., Carl D. Perchonock
  • Lipoxygenase inhibitors
    Patent number: 5140047
    Abstract: Tricyclic hydroxyurea and hydroxamate compounds, pharmaceutical compositions, and their use as as inhibitors of the oxidation of polyunsaturated fatty acids, such as by inhibition on the 5-lipoxygenase enzyme, and treatment of diseases therein.
    Type: Grant
    Filed: May 3, 1991
    Date of Patent: August 18, 1992
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Ravi S. Garigipati
  • Steroidal 14.alpha.-carboxy-alkyl derivatives as regulators of HMG-COA reductase
    Patent number: 5023250
    Abstract: New 14.alpha.-carboxyalkyl sterols are regulators of HMG-CoA reductase and inhibitors of mammalian 14.alpha.-methyl demethylase and are useful in lowering serum cholesterol levels and treating fungal infections.
    Type: Grant
    Filed: August 24, 1989
    Date of Patent: June 11, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Timothy F. Gallagher, Ruth J. Mayer, Brian W. Metcalf
  • Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
    Patent number: 5002941
    Abstract: Compounds comprising pyridyl and phenyl substituted pyrrolo[1,2-a]imidazole derivatives and pyridyl and phenyl substituted imidazo[1,2-a]pyridine derivatives, pharmaceutical compositions containing said compounds, and their use as 5-lipoxygenase pathway inhibitors.
    Type: Grant
    Filed: October 11, 1988
    Date of Patent: March 26, 1991
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Paul E. Bender, John G. Gleason, Nabil Hanna, John F. Newton, Jr., Carl D. Perchonock, Kazys Razgaitis
  • .alpha.-Aminobutyric acid transaminase inhibitors
    Patent number: 4520028
    Abstract: This application relates to 4-amino-4,5-dihydro-2-thiophenecarboxylic acid, the C.sub.1-6 alkyl esters thereof and to their use in the treatment of epilepsy.
    Type: Grant
    Filed: September 5, 1984
    Date of Patent: May 28, 1985
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Jerry L. Adams, Brian W. Metcalf, Bruce J. Lippert
  • Production of intermediates for enzyme inhibitors
    Patent number: 4325877
    Abstract: 5-Amino-4-oxo-pentanoic acids of the formula ##STR1## wherein R is CF.sub.3, CHF.sub.2 or CH.sub.2 F; R.sub.1 is H or akyl of 1-4 carbon atoms; and R.sub.2 is H or alkyl or 1-4 carbon atoms or benzyl, which are intermediates to ACE inhibitors or elastase inhibitors, are produced by reacting a 1-(methylthio)-1-methylsulfinyl)-2-R.sub.1 -ethylmetal with an ester of a 3-R-acrylic acid; optionally R.sub.2 -alkylating the thus-produced ester enolate anion of 4-(methylsulfinyl)-4-(methylthio)-5-R.sub.1 R-pentanoic acid followed by splitting off of methylsulfinic acid; reacting the thus-produced 2-R.sub.2 -5-R.sub.1 -4-(methylthio)-3-R-4-pentenoic acid ester with a source of Br.sup.+ to produce a 5-bromo-substituted acid or ester thereof otherwise corresponding to the desired 5-amino-4-oxo-pentanoic acid; and replacing the bromine atom with an amino group, e.g., via the corresponding 5-azido- and 5-N-acylamino- compounds, with hydrolysis of the ester group, if still remaining.
    Type: Grant
    Filed: June 16, 1980
    Date of Patent: April 20, 1982
    Assignee: Richardson-Merrell Inc.
    Inventors: Brian W. Metcalf, Jerry L. Adams