Patents by Inventor Jerry R. Reel

Jerry R. Reel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 11 .beta.-substituted progesterone analogs
    Patent number: 5073548
    Abstract: A 11.beta.-aryl-19-norprogesterone steroid of the formula: ##STR1## wherein (i) R.sup.1 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, OH, OC(O)CH.sub.3, or OC(O)R.sup.5 , wherein R.sup.5 is C.sub.2-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl or aryl, R.sub.2 is H, R.sup.3 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl, R.sup.4 is H, CH.sub.3, F or Cl, R.sup.6 is H, (CH.sub.3).sub.2 N, CH.sub.3 O, CH.sub.3 CO, CH.sub.3 S, CH.sub.3 SO, CH.sub.3 SO.sub.2, and X is O or NOCH.sub.3 ; or(ii) R.sup.1 and R.sup.2 taken together are a carbon-carbon bond and R.sup.3, R.sup.4, R.sup.6 and X are as defined above; or(iii) R.sup.1 and R.sup.3 taken together are --CH.sub.2 -- or --N.dbd.N--CH.sub.2 --, R.sup.2 is H and R.sup.4, R.sup.6 and X are as defined above; or(iv) R.sup.2 and R.sup.3 taken together are .dbd.CH.sub.2 and R.sup.1 , R.sup.4, R.sup.6 and X are as defined above.
    Type: Grant
    Filed: April 3, 1990
    Date of Patent: December 17, 1991
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, Mansukh C. Wani, Yun W. Lee, Jerry R. Reel, Douglas Rector
  • 11 .beta.-substituted progesterone analogs
    Patent number: 4954490
    Abstract: A 11.beta.-aryl-19-norprogesterone steroid of the formula: ##STR1## wherein (i) R.sup.1 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, OH, OC(O)CH.sub.3, or OC(O)R.sup.5, wherein R.sup.5 is C.sub.2-8 alkyl, C.sub.2-8 alkenyl, C.sub.2-8 alkynyl or aryl, R.sub.2 is H, R.sup.3 is H, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl, R.sup.4 is H, CH.sub.3, F or Cl, R.sup.6 is H, (CH.sub.3).sub.2 N, CH.sub.3 O, CH.sub.3 CO, CH.sub.3 S, CH.sub.3 SO, CH.sub.3 SO.sub.2, and X is O or NOCH.sub.3 ; or(ii) R.sup.1 and R.sup.2 taken together are a carbon-carbon bond and R.sup.3, R.sup.4, R.sup.6 and X are as defined above; or(iii) R.sup.1 and R.sup.3 taken together are --CH.sub.2 -- or --N.dbd.N--CH.sub.2 --, R.sup.2 is H and R.sup.4, R.sup.6 and X are as defined above; or(iv) R.sup.2 and R.sup.3 taken together are .dbd.CH.sub.2 and R.sup.1, R.sup.4, R.sup.6 and X are as defined above.
    Type: Grant
    Filed: June 23, 1988
    Date of Patent: September 4, 1990
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, Mansukh C. Wani, Y.-W Lee, Jerry R. Reel, Douglas Rector
  • 17 .alpha.-(substituted-methyl)-17.beta.-hydroxy/esterified hydroxy steroids and their progestational use
    Patent number: 4861763
    Abstract: Steroids of the formula: ##STR1## which are characterized by a 17.alpha.-cyanomethyl, azidomethyl, methoxymethyl, phenylmethyl, or ethynylmethyl substituent and a 17.beta.-hydroxy/esterified hydroxy substitutent. The steroids of this invention have glucocorticoid, anti-glucocorticoid, progrestational, or anti-progestational activity, depending on the particular structure.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: August 29, 1989
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, C. Ray Tallent, Jerry R. Reel, Mansukh C. Wani
  • 17.alpha.-(substituted-methyl)-17.beta.-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
    Patent number: 4774236
    Abstract: Steroids of the formula: ##STR1## which are characterized by a 17.alpha.-cyanomethyl, azidomethyl, methoxymethyl, phenylmethyl, or ethynylmethyl substituent and a 17.beta.-hydroxy/esterified hydroxy substituent. The steroids of this invention have glucocorticoid, anti-glucocorticoid, progestational, or anti-progestational activity, depending on the particular structure.
    Type: Grant
    Filed: September 17, 1986
    Date of Patent: September 27, 1988
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, C. Ray Tallent, Jerry R. Reel, Mansukh C. Wani
  • Progrestationally active steroids
    Patent number: 4512986
    Abstract: Novel steroids having the formula ##STR1## wherein R.sup.1 is selected from the group consisting of methyl, ethyl, and propyl;R.sup.2 is selected from the group consisting of H and methyl;R.sup.3 is selected from the group consisting of OXO and H(OR.sup.5); ##STR2## wherein R.sub.4 is selected from the group consisting of H.sub.2, H(methyl), H(Cl), H(F), and .dbd.CH.sub.2 ; or ##STR3## wherein R is selected from the group consisting of H, methyl, Cl, and F. Q-S is selected from the group consisting of --CH.dbd.CH-- and --CH.sub.2 CH--.Also disclosed is a method for making and therapeutically using the steroids and for making the intermediates.
    Type: Grant
    Filed: July 26, 1983
    Date of Patent: April 23, 1985
    Assignee: Research Triangle Institute
    Inventors: Jerry R. Reel, Clarence E. Cook