Abstract: A computer-implemented method for revising structural parameters of a physical device is provided. The method comprises configuring a simulated environment to be representative of the physical device based on an initial description that describes structural parameters of the physical device. The method further includes performing an operational simulation of the physical device based on training data representative of physical stimuli within a physical domain to simulate an interaction between the physical device and the physical stimuli. The method further includes computing a loss value based on a simulated output of the physical device and performing and adjoint simulation by backpropagating the loss value through the simulated environment. The method also includes generating a revised description of the physical device by updating the structural parameters to reduce the loss value.

Abstract: A technique for simulating and optimizing the fabrication and design of a physical device is described. The technique includes executing a fabrication simulation of the physical device with a fabrication model that receives a fabrication specification as input and outputs a structural design for the physical device in response to the fabrication simulation. An operational simulation of the physical device is executed with a design model that simulates a field response propagating through a simulated environment of the physical device. The structural design output from the fabrication model is forward cascaded to the design model and an output from backpropagation of a performance loss error through the design model is reverse cascaded to the fabrication model.

Abstract: Disclosed is an assay device comprising a high density of wells aligned thereon.

Abstract: A multi-channel photonic demultiplexer includes an input region to receive a multi-channel optical signal including four distinct wavelength channels, four output regions, each adapted to receive a corresponding one of the four distinct wavelength channels demultiplexed from the multi-channel optical signal, and a dispersive region optically disposed between the input region and the four output regions. The dispersive region includes a first material and a second material inhomogeneously interspersed to form a plurality of interfaces that each correspond to a change in refractive index of the dispersive region and collectively structure the dispersive region to optically separate each of the four distinct wavelength channels from the multi-channel optical signal and respectively guide each of the four distinct wavelength channels to the corresponding one of the four output regions.

Abstract: Disclosed is an assay device comprising a high density of wells aligned thereon.

Abstract: Embodiments of techniques for inverse design of physical devices are described herein, in the context of generating designs for photonic integrated circuits (including a multi-channel photonic demultiplexer). In some embodiments, an initial design of the physical device is received, and a plurality of sets of operating conditions for fabrication of the physical device are determined. In some embodiments, the performance of the physical device as fabricated under the sets of operating conditions is simulated, and a total performance loss value is backpropagated to determine a gradient to be used to update the initial design. In some embodiments, instead of simulating fabrication of the physical device under the sets of operating conditions, a robustness loss is determined and combined with the performance loss to determine the gradient.

Abstract: A multi-channel photonic demultiplexer includes an input region to receive a multi-channel optical signal including four distinct wavelength channels, four output regions, each adapted to receive a corresponding one of the four distinct wavelength channels demultiplexed from the multi-channel optical signal, and a dispersive region optically disposed between the input region and the four output regions. The dispersive region includes a first material and a second material inhomogeneously interspersed to form a plurality of interfaces that each correspond to a change in refractive index of the dispersive region and collectively structure the dispersive region to optically separate each of the four distinct wavelength channels from the multi-channel optical signal and respectively guide each of the four distinct wavelength channels to the corresponding one of the four output regions.

Abstract: A method and system for optimizing structural parameters of a physical device is described. The method includes receiving an initial description of the physical device that describes structural parameters of the physical device within a simulated environment. The method further includes performing an operational simulation of the physical device in response to an excitation source, performing an adjoint simulation by backpropagating a placeholder metric through a simulated environment to determine a loss gradient, updating the loss gradient based, at least in part, on a loss metric determined from the operational simulation. Additionally, the method further comprises computing a structural gradient corresponding to an influence of changes in the structural parameters on the loss metric and generating a revised description of the physical device by updating the structural parameters based on the structural gradient to reduce the loss metric.

Abstract: A two-channel photonic demultiplexer includes an input region to receive a multi-channel optical signal, two output regions, each adapted to receive a corresponding one of two distinct wavelength channels demultiplexed from the multi-channel optical signal, and a dispersive region including a first material and a second material inhomogeneously interspersed to form a plurality of interfaces that collectively structure the dispersive region to optically separate each of the two distinct wavelength channels from the multi-channel optical signal and respectively guide the first distinct wavelength channel to a first output region and the second distinct wavelength channel to the second output region when the input region receives the multi-channel optical signal. At least one of the first material or the second material is structured within the dispersive region to be schematically reproducible by a feature shape with a pre-determined width.

Abstract: A microfluidic system for fluid transport is provided. The microfluidic system includes a microfluidic device. The microfluidic device includes an inlet body including an inlet. The microfluidic device includes a base supporting the inlet body. The base includes a channel in fluid communication with the inlet. The base includes one or more sensors formed on a surface of the channel, or one or more sensors formed in one or more wells formed in the surface of the channel. The channel is configured to facilitate flow of the fluid. The fluid includes a plurality of beads. The fluid includes a plurality of suspended cells. The inlet is configured to receive the fluid at an inlet port. The inlet is configured to output the fluid through an opening in fluid communication with the channel. The inlet is configured to provide substantially uniform flow of the fluid across a substantial portion of a horizontal dimension of the channel. The device is configured to compensate for edge effects otherwise present therein.

Abstract: A method and system for optimizing structural parameters of an electromagnetic device is described that includes performing operations. The operations include performing a time-forward simulation of a field response in a simulated environment describing the electromagnetic device and extracting decomposition components from the field response to compute a loss value. The operations further include backpropagating the loss value backwards in time using the decomposition components to determine an influence of changes in the structural parameters of the electromagnetic device on the loss value. The operations further include generating a revised description of the electromagnetic device by updating the structural parameters to reduce the loss value.

Abstract: Embodiments of techniques for inverse design of physical devices are described herein, in the context of generating designs for photonic integrated circuits (including a multi-channel photonic demultiplexer). In some embodiments, an initial design of the physical device is received, and a plurality of sets of operating conditions for fabrication of the physical device are determined. In some embodiments, the performance of the physical device as fabricated under the sets of operating conditions is simulated, and a total performance loss value is backpropagated to determine a gradient to be used to update the initial design. In some embodiments, instead of simulating fabrication of the physical device under the sets of operating conditions, a robustness loss is determined and combined with the performance loss to determine the gradient.

Abstract: A two-channel photonic demultiplexer includes an input region to receive a multi-channel optical signal, two output regions, each adapted to receive a corresponding one of two distinct wavelength channels demultiplexed from the multi-channel optical signal, and a dispersive region including a first material and a second material inhomogeneously interspersed to form a plurality of interfaces that collectively structure the dispersive region to optically separate each of the two distinct wavelength channels from the multi-channel optical signal and respectively guide the first distinct wavelength channel to a first output region and the second distinct wavelength channel to the second output region when the input region receives the multi-channel optical signal. At least one of the first material or the second material is structured within the dispersive region to be schematically reproducible by a feature shape with a pre-determined width.

Abstract: A system, apparatus, and method for optimizing structural parameters of a physical device are described. The method includes receiving an initial description of the physical device describing the structural parameters within a simulated environment. The method further includes performing a simulation of the physical device in response to an excitation source to determine a performance metric of the physical device. The simulation environment includes one or more absorbing boundaries for attenuation of an output of the excitation source during the simulation. The method further includes recording attenuated field values of the simulated environment associated with the attenuation during the simulation.

Abstract: Techniques for ensuring fabricability of segmented designs are provided. In some embodiments, a computing system receives a design specification to be used to create a proposed segmented design. Each segment of the proposed segmented design indicates a material within the segment. The proposed segmented design includes segments that indicate at least two different materials. The computing system chooses a segment to touch with a paintbrush pattern for a first material. The computing system updates a set of material statuses for each material based on the chosen segment. The computing system updates a set of touch statuses for each material based on the chosen segment. The choosing and updating actions are repeated until all segments are associated with a material. The computing system generates the proposed segmented design based on the sets of material statuses.

Abstract: This disclosure provides for devices and methods for conduction assays for combinatorial libraries. The devices comprise a multiplicity of wells and a removable cap.

Abstract: Methods for designing a mode-selective optical device including one or more optical interfaces defining an optical cavity include: defining a loss function within a simulation space encompassing the optical device, the loss function corresponding to an electromagnetic field having an operative wavelength within the optical device resulting from an interaction between an input electromagnetic field at the operative wavelength and the one or more optical interfaces of the optical device; defining an initial structure for each of the one or more optical interfaces, each initial structure being defined using a plurality of voxels; determining values for at least one structural parameter and/or at least one functional parameter of the one or more optical interfaces by solving Maxwell's equations; and defining a final structure of the one or more optical interfaces based on the values for the one or more structural and/or functional parameters.

Abstract: A system, apparatus, and method for optimizing structural parameters of a physical device are described. The method includes receiving an initial description of the physical device describing the structural parameters within a simulated environment. The method further includes performing a simulation of the physical device in response to an excitation source to determine a performance metric of the physical device. The simulation environment includes one or more absorbing boundaries for attenuation of an output of the excitation source during the simulation. The method further includes recording attenuated field values of the simulated environment associated with the attenuation during the simulation.

Abstract: Embodiments of techniques for inverse design of physical devices are described herein, in the context of generating designs for photonic integrated circuits (including a multi-channel photonic demultiplexer). In some embodiments, an initial design of the physical device is received, and a plurality of sets of operating conditions for fabrication of the physical device are determined. In some embodiments, the performance of the physical device as fabricated under the sets of operating conditions is simulated, and a total performance loss value is backpropagated to determine a gradient to be used to update the initial design. In some embodiments, instead of simulating fabrication of the physical device under the sets of operating conditions, a robustness loss is determined and combined with the performance loss to determine the gradient.

Abstract: Disclosed is an assay device comprising a high density of wells aligned thereon.