Patents by Inventor Jewell L. Osterholm
Jewell L. Osterholm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5085630Abstract: The invention provides novel improved oxygenated fluorocarbon nutrient solutions for treatment of hypoxic-ischemic neurologic tissue in mammals. The invention also provides methods of making such nutrient solution and methods of administering them.Type: GrantFiled: May 21, 1990Date of Patent: February 4, 1992Assignee: Thomas Jefferson UniversityInventors: Jewell L. Osterholm, Glenn D. Frazer
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Patent number: 4981691Abstract: The invention provides novel improved oxygenated fluorocarbon nutrient solutions for treatment of hypoxic-ischemic neurologic tissue in mammals. The invention also provides methods of making such nutrient solution and methods of administering them.Type: GrantFiled: April 5, 1989Date of Patent: January 1, 1991Assignee: Thomas Jefferson UniversityInventors: Jewell L. Osterholm, Glenn D. Frazer
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Patent number: 4963130Abstract: A novel method of oxygenating the tissue of a living mammal is disclosed comprising the steps of providing an oxygenated fluorocarbon-containing liquid; injecting that oxygenated liquid into the peritoneal cavity of said mammal; and withdrawing said fluorocarbon liquid from said cavity, said injecting and withdrawing be conducted at a rate sufficient to oxygenate said tissue. Accordingly, a novel "artificial lung" is disclosed which is useful to selectively oxygenate the body of a mammal, as reflected by increased arterial blood gas (pO.sub.2) in said mammal.Type: GrantFiled: November 18, 1986Date of Patent: October 16, 1990Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4840617Abstract: A cerebral catheterization apparatus for delivering oxygenated nutrient to or from the cerebro-spinal fluid pathway of a patient suspected of suffering from ischemic central nervous system tissue is disclosed. The apparatus comprises catheter means for providing a delivery pathway for an oxygenated nutrient to the lateral ventricle of the brain, which delivery pathway comprises an inlet and outlet; guide means, mating with the catheter means, for directing the catheter means toward the lateral ventricle; and a harness, on which the guide means is mounted, which is positionable with respect to the patient's head such that the catheter means may be reliably inserted into the lateral ventricle.Type: GrantFiled: August 24, 1988Date of Patent: June 20, 1989Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4830849Abstract: A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the crebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.Type: GrantFiled: April 14, 1988Date of Patent: May 16, 1989Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4795423Abstract: A novel method of treating ischemic retinopathy is disclosed. After diagnosis of ischemic retinopathy, as for example as a result of retinal infarction, the ocular globe is penetrated with two small cannulae. An inflow and outflow perfusion is then established with an oxygenated perfluorochemical emulsion or other physiologically compatible oxygenated liquid. A sufficient perfusion rate is established and maintained to provide the metabolic needs of the retina for the 3 to 5 day period necessary to permit the natural healing process to occur. The method comprises removing at least a portion of vitreous body to create an intraocular perfusion space and establishing a perfusion of physiologically compatible oxygenated fluid through that perfusion space at a rate and for a duration sufficient to permit the natural healing process to occur. Alternatively, a method of diagnosing the condition of retinal tissue suspected of being ischemic is disclosed.Type: GrantFiled: August 28, 1986Date of Patent: January 3, 1989Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4758431Abstract: A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagonising the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.Type: GrantFiled: September 30, 1982Date of Patent: July 19, 1988Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4686085Abstract: A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.Type: GrantFiled: February 23, 1984Date of Patent: August 11, 1987Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4657532Abstract: A novel method of oxygenating the tissue of a living mammal is disclosed comprising the steps of providing an oxygenated fluorocarbon-containing liquid; injecting that oxygenated liquid into the peritoneal cavity of said mammal; and withdrawing said fluorocarbon liquid from said cavity, said injecting and withdrawing be conducted at a rate sufficient to oxygenate said tissue. Accordingly, a novel "artificial lung" is disclosed which is useful to selectively oxygenate the body of a mammal, as reflected by increased arterial blood gas (pO.sub.2) in said mammal.Type: GrantFiled: July 19, 1985Date of Patent: April 14, 1987Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4608635Abstract: A computer-assisted tomographic image is overlayed with the visual indication of any regions representing a deviation from a norm. The overlaid region may indicate a deviation of the radiodensity in that region. The overlaid region may also indicate a deviation from an electrophysiological norm based on compressed spectral analysis of an electroencephalographic signal or evoked potentials represented by such a signal.Type: GrantFiled: May 23, 1985Date of Patent: August 26, 1986Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4532591Abstract: A computer-assisted tomographic image is overlayed with the visual indication of any regions representing a deviation from a norm. The overlaid region may indicate a deviation of the radiodensity in that region. The overlaid region may also indicate a deviation from an electrophysiological norm based on compressed spectral analysis of an electroencephalographic signal or evoked potentials represented by such a signal.Type: GrantFiled: August 3, 1982Date of Patent: July 30, 1985Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4450841Abstract: A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.Type: GrantFiled: September 30, 1982Date of Patent: May 29, 1984Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4451251Abstract: A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.Type: GrantFiled: September 30, 1982Date of Patent: May 29, 1984Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4445888Abstract: A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.Type: GrantFiled: September 30, 1982Date of Patent: May 1, 1984Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4445887Abstract: A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.Type: GrantFiled: September 30, 1982Date of Patent: May 1, 1984Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4445500Abstract: A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischmeic and other diseased neurologic tissue during treatment are provided.Type: GrantFiled: September 30, 1982Date of Patent: May 1, 1984Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4445514Abstract: A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.Type: GrantFiled: June 18, 1981Date of Patent: May 1, 1984Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4445886Abstract: A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.Type: GrantFiled: March 3, 1982Date of Patent: May 1, 1984Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4446155Abstract: A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischmeic and other diseased neurologic tissue during treatment are provided.Type: GrantFiled: September 30, 1982Date of Patent: May 1, 1984Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm
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Patent number: 4446154Abstract: A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.Type: GrantFiled: September 30, 1982Date of Patent: May 1, 1984Assignee: Thomas Jefferson UniversityInventor: Jewell L. Osterholm