Abstract: The present invention relates to kinds and effects of various materials derived from the placenta, in particular, kinds and effects of diverse biomolecules including: extracellular vesicle (EV) derived from the placenta, umbilical cord and/or cord blood, placental mesenchymal stem cell (pMSC) derived from the placenta, umbilical cord and/or cord blood, EVs derived from the above bio-materials, as well as miRNA and cargo contained in the above EVs. In this regard, miRNA contained in the EV efficiently degrades RNA genome of corona virus, thereby exhibiting direct anti-viral effects. Further, indirect effects of preventing and treating different virus infections owing to antiinflammatory effects of various biomolecules inherently included in EV, can be identified, thereby completing the present invention.

Abstract: Provided are a biomarker for diagnosing of the level of senescence, a composition and kit for diagnosing of the level of senescence to detect the biomarker, and a method of diagnosing the same. According to the composition and kit for the diagnosis of the level of senescence and the method of diagnosing senescence, the level of senescence of a subject is easily diagnosed, the health conditions of the subject are monitored, and a senescence-associated disease is prevented or diagnosed.

Abstract: Provided are a brain-derived vesicle-specific marker and a brain disease diagnostic method using the same. According to one aspect, by using a marker which specifically expresses in brain-derived vesicles, brain-derived vesicles may be isolated in a highly efficient and highly specific manner without having to collect tissue, and vesicles which specifically express in each region of the brain may be isolated. Also, a brain disease condition may be diagnosed by means of an expression profile of a marker specific to a brain region in brain-derived vesicles which have been isolated by means of the marker according to one aspect.

Abstract: Provided are a biomarker for diagnosing of the level of senescence, a composition and kit for diagnosing of the level of senescence to detect the biomarker, and a method of diagnosing the same. According to the composition and kit for the diagnosis of the level of senescence and the method of diagnosing senescence, the level of senescence of a subject is easily diagnosed, the health conditions of the subject are monitored, and a senescence-associated disease is prevented or diagnosed.

Abstract: The present invention relates to placenta-derived cells excreting C3 or C1R complement proteins, a pharmaceutical composition containing same, and a method for treating diseases using the placenta-derived cells. The placenta-derived cells, according to the present invention, can be effectively applied to Alzheimer's disease, Parkinson's disease, HIV, neurodegenerative diseases such as dementia and epilepsy, or angiogenesis-related diseases such as cancer and retinopathy, thereby having high industrial utility.

Abstract: The present invention provides a method for proliferating neural progenitor cells and a composition for treating neurological diseases, the composition including a proliferated neural progenitor cell. When a fetal neural progenitor cell is cultured under a hypoxia condition and/or in a medium containing tocoperol, tocoperol acetate, or a mixture thereof, the improved cell proliferation rates of the fetal neural progenitor cell are confirmed. In addition, considering an effect of the neural progenitor cell on preventing differentiation thereof into neurons at the time of proliferation, the present disclosure may contribute to mass production of neural stem cells, and accordingly, the proliferated neural progenitor cell is expected to be utilized in the treatment of a neurological disease.

Abstract: The present invention provides a method for differentiating human neural progenitor cells into dopaminergic neurons, comprising the step of culturing human neural progenitor cells in a medium containing fusaric acid. In addition, the present invention provides a medium for differentiation of human neural progenitor cells into dopaminergic neurons.

Abstract: The present invention provides a method for differentiating human neural progenitor cells into dopaminergic neurons, comprising the step of culturing human neural progenitor cells in a medium containing fusaric acid. In addition, the present invention provides a medium for differentiation of human neural progenitor cells into dopaminergic neurons.