Abstract: In one implementation, a computer-implemented method includes: receiving, at a computer system, a multimedia message service (MMS) message for delivery to a client computing device; storing, by the computer system, the MMS message; generating, by the computer system, a traditional short message service (SMS) message including a notification that the MMS message is available for download from the computer system; transmitting, by the computer system, the SMS message to the client computing device; receiving, after transmitting the SMS message, a request from the client computing device to download the MMS message; and sending, by the computer system, the MMS message to the client computing device.

Abstract: A method and system for improving a shared memory file transfer setup and usage is provided. The method includes configuring network links connected between hardware nodes. For every shared storage link, each hardware node includes a command section and a data storage section. A storage capacity for a hardware disk drive is determined based on a number of the hardware nodes and the hardware disk drive is connected to the hardware nodes. A software agent is installed within each of the hardware nodes and properties for the network links are configured. Each software agent is enabled and a connectivity status, bandwidth, and loading condition are tested for each of the network links. Each hardware node is registered with the hardware disk drive and communications between the hardware disk drive and the hardware nodes are enabled via the network links.

Abstract: An output stage circuit including an amplifier, a switching circuit and a selection circuit is provided. The amplifier converts an input signal into an output signal. The switching circuit is coupled between an output terminal of the amplifier and ground. The selection circuit includes a first-mode-selection-unit and a second-mode-selection unit. The first control signal is selected as a switching signal by the first-mode-selection unit when a power-detection signal is in a high level, so that the switching circuit is selectively turned on. The switching circuit is turned on according to a voltage stored in a storage capacitor of the second-mode-selection unit when the power-detection signal is in a low level, so that the output terminal of the amplifier is coupled to the ground.

Abstract: One example embodiment is a lignanamide that includes a benzo-angular triquinane skeleton. The lignanamide is represented by formula (I) and any derivative of the formula (I), in which R is represented by —OH or —OCH3. Another example embodiment relates to a method of treating neurodegenerative disease by administering the lignanamide of the formula (I) to a person in need thereof.

Abstract: One example embodiment is a lignanamide that includes a benzo-angular triquinane skeleton. The lignanamide is represented by formula (I) and any derivative of the formula (I), in which R is represented by —OH or —OCH3. Another example embodiment relates to a method of treating neurodegenerative disease by administering the lignanamide of the formula (I) to a person in need thereof.

Abstract: An output stage circuit including an amplifier, a switching circuit and a selection circuit is provided. The amplifier converts an input signal into an output signal. The switching circuit is coupled between an output terminal of the amplifier and ground. The selection circuit includes a first-mode-selection-unit and a second-mode-selection unit. The first control signal is selected as a switching signal by the first-mode-selection unit when a power-detection signal is in a high level, so that the switching circuit is selectively turned on. The switching circuit is turned on according to a voltage stored in a storage capacitor of the second-mode-selection unit when the power-detection signal is in a low level, so that the output terminal of the amplifier is coupled to the ground.

Abstract: The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-?, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.

Abstract: The present invention relates to a composition comprising metformin as an active ingredient for preventing or treating inflammatory bowel disease. The metformin compound or the metformin-etanercept (product name: Enbrel) composite according to the present invention may have excellent effects of maintaining the thickness of the small intestine and length of the large intestine normal, inhibiting or decreasing the activity of IL-17 and TNF-a, and promoting or increasing the activity of IFNr, and therefore can be effectively used as a pharmaceutical composition for preventing or treating autoimmune diseases including inflammatory bowel disease.

Abstract: The present invention relates to a composition for preventing or treating immune diseases through the suppression of B cell activity induced by metformin. More particularly, the present invention relates to a composition comprising a metformin compound or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating immune diseases, wherein the composition is characterized by suppression or reduction of B cell activity which is a cause of disease. The present invention can be valuable in the use thereof for various autoimmune diseases as an immunosuppressant which can prevent or treat immune diseases by suppressing or reducing B cell activity and Th17 cell activity, which are causes of disease, or by promoting or increasing regulatory T cell activity.

Abstract: The present invention relates to a composition for preventing or treating an autoimmune disease comprising, as an active ingredient, PINK1 protein or polynucleotide encoding the same. The PINK1 protein according to the present invention inhibits the activity of Th17, promotes the activity of a regulatory T cell (Treg), and increases autophagy in Treg cells, thereby controlling excessive immune responses. Therefore, the PINK1 protein can be effectively used as a pharmaceutical composition or an immunosuppressant, which is capable of preventing or treating an autoimmune disease, such as arthritis, and the like, caused by dysregulation of various kinds of immune responses.

Abstract: An example method is provided to process an input in a virtualized computing environment. The virtualized computing environment may include a physical machine running a host operating system and a virtualization software with one or more virtual machines. The example method may include detecting activation of at least one key input that causes a first message to be generated, the first message associated with the key input, comparing the first message with a set of stored messages, wherein any of the set of stored messages can be properly executed by targets in both the host operating system and the virtual machine but with different responses, and determining, based on the comparing, whether the first message is intended for a target in the host operating system or in the virtual machine.

Abstract: The daurinol compound according to the present invention exhibits excellent therapeutic effects on arthritis and inflammatory bowel diseases by having an excellent activity in inhibiting the generation of IL-17 and TNF-?, which are inflammatory cytokines causing inflammation, and can alleviate transplant rejection by inhibiting the proliferation of alloreactive T cells and increasing regulatory T cells; therefore, the daurinol compound according to the present invention can be used as a pharmaceutical composition capable of treating and preventing immune diseases. In addition, being a natural substance derived from the Mongolian medicinal plant Haplophyllum dauricum or Haplophyllum cappadocicum, the daurinol compound according to the present invention does not cause cytotoxicity and thus may be used as a composition for a functional health food capable of preventing and remedying immune diseases.

Abstract: In one implementation, a computer-implemented method includes: receiving, at a computer system, a multimedia message service (MMS) message for delivery to a client computing device; storing, by the computer system, the MMS message; generating, by the computer system, a traditional short message service (SMS) message including a notification that the MMS message is available for download from the computer system; transmitting, by the computer system, the SMS message to the client computing device; receiving, after transmitting the SMS message, a request from the client computing device to download the MMS message; and sending, by the computer system, the MMS message to the client computing device.

Abstract: A blade-type fluid transmission device includes a rotor eccentrically located in the room of a stator and the outer periphery of the rotor is tangent to the inner periphery of the room. At least one blade is pivotably connected to stator and movably inserted in at least one slot of the rotor. The distal end of the at least one blade is in contact with the inner periphery of the room so as to form a space for receiving fluid between the outer periphery of the rotor and the inner periphery of the room. The contact between the at least one blade and the inner periphery of the room increases the efficiency for transmitting fluid which enters into the stator from an inlet and leaves from the stator from an outlet.

Abstract: A virtual machine system clones a parent virtual machine on a host by creating an open virtualization format (OVF) package of the parent virtual machine, creating a metainfo file of the OVF package, sending the metainfo file to a tracker, and cloning the parent virtual machine to other hosts by accessing the tracker to determine pieces of the OVF packages are located on the host and any of the other hosts, downloading the pieces of the OVF packages to the other hosts, assembling the OVF package on the other hosts, and deploying full clones of the parent virtual machine on the other hosts from the assembled OVF package.

Abstract: The present invention relates to a mesenchymal stem cell having immunomodulatory activity and a preparation method therefor and, more specifically, to: a rapamycin-treated mesenchymal stem cell having immunomodulatory activity, which expresses any one or more cell surface factors selected from the group consisting of CCR1, CCR2, CCR3, CCR4, CCR7, CCR9 and CXCR4; a cell therapy composition comprising the mesenchymal stem cell, for preventing or treating immune disorders; and a preparation method for the mesenchymal stem cell having immunomodulatory activity. The rapamycin-treated mesenchymal stem cell having immunomodulatory activity, according to the present invention, has increased expression of IDO, TGF-? and IL-10 which are factors having immunomodulatory activity, has decreased expression of Phospho-mTOR, Rictor and Ractor which are signal transduction factors of mTOR, and has increased expression, in the cell, of autophagic inducer Beclin1, ATG5, ATG7, LC3I or LCII.

Abstract: A virtual machine system clones a parent virtual machine on a host by creating an open virtualization format (OVF) package of the parent virtual machine, creating a metainfo file of the OVF package, sending the metainfo file to a tracker, and cloning the parent virtual machine to other hosts by accessing the tracker to determine pieces of the OVF packages are located on the host and any of the other hosts, downloading the pieces of the OVF packages to the other hosts, assembling the OVF package on the other hosts, and deploying full clones of the parent virtual machine on the other hosts from the assembled OVF package.

Abstract: An example method is provided to process an input in a virtualized computing environment. The virtualized computing environment may include a physical machine running a host operating system and a virtualization software with one or more virtual machines. The example method may include detecting activation of at least one key input that causes a first message to be generated, the first message associated with the key input, comparing the first message with a set of stored messages, wherein any of the set of stored messages can be properly executed by targets in both the host operating system and the virtual machine but with different responses, and determining, based on the comparing, whether the first message is intended for a target in the host operating system or in the virtual machine.

Abstract: The daurinol compound according to the present invention exhibits excellent therapeutic effects on arthritis and inflammatory bowel diseases by having an excellent activity in inhibiting the generation of IL-17 and TNF-?, which are inflammatory cytokines causing inflammation, and can alleviate transplant rejection by inhibiting the proliferation of alloreactive T cells and increasing regulatory T cells; therefore, the daurinol compound according to the present invention can be used as a pharmaceutical composition capable of treating and preventing immune diseases. In addition, being a natural substance derived from the Mongolian medicinal plant Haplophyllum dauricum or Haplophyllum cappadocicum, the daurinol compound according to the present invention does not cause cytotoxicity and thus may be used as a composition for a functional health food capable of preventing and remedying immune diseases.

Abstract: An example method is provided to process an input in a virtualized computing environment. The virtualized computing environment may include a physical machine running a host operating system and a virtualization software with one or more virtual machines. The example method may include detecting activation of at least one key input that causes a first message to be generated, the first message associated with the key input, comparing the first message with a set of stored messages, wherein any of the set of stored messages can be properly executed by targets in both the host operating system and the virtual machine but with different responses, and determining, based on the comparing, whether the first message is intended for a target in the host operating system or in the virtual machine.