Abstract: The present disclosure provides a data acquisition and control system of pulsed power supply for multi-load, and relates to the technical field of pulsed power. The system of the present disclosure is configured to control 18 sets of pulsed power supplies to provide 18 coils with stable and reliable excitation current featuring multiple output time sequences and flexible adjustability, such that a near-earth space plasma environment ground-based simulation device can simulate the magnetic field topology of the earth magnetosphere and realize a background magnetic field required by physical experiments. The system mainly achieves the following functions: control over charge and discharge of pulsed power supplies, selection of power supplies put in use, “delay trigger” setting, voltage monitoring, status monitoring of key components and output current display; and it is also necessary to realize failure alarm and failure handling for the purpose of ensuring the safety of equipment and personnel.

Abstract: Described herein are improvements relating to IGF-1 function analysis, adjustment and its application in disease management of non-neurological and/or neurological conditions. More specifically, methods relating to the clinical application of cyclic glycine-proline (cGP) and/or cGP/IGF-1 molar ratio as the plasma biomarker for prediction of risk and recovery of non-neurological and/or neurological conditions with IGF-1 dysfunction and the use of a cGP containing animal, marine or fungal based material such as concentrate/extract of hydrolysed bovine collagen and marine collagen, mushroom and seaweed along with plant-based cGPMAX™ for the treatment of same. The methods more accurately measure IGF-1 function in vivo indirectly using cGP and cGP/IGF-1 molar ratio along with a means to adjust and normalise cGP and cGP/IGF-1 molar ratio (and hence active IGF-1 concentration), and specific treatment methods for individuals with a lower or reduction of cGP level relative to a standard set of baseline data.

Abstract: A diffraction optical waveguide structure is provided. The diffraction optical waveguide structure includes a light-guiding layer, a coupling-in region, a deflecting region and a coupling-out region, all disposed on the light-guiding layer, and are sequentially arranged along a direction of an optical path. The coupling-in region, the deflecting region and the coupling-out region are all configured with a first diffractive microstructure layer. Additionally, the diffraction optical waveguide structure further includes a light-homogenizing region, the light-homogenizing region is arranged between the deflecting region and the coupling-out region, the light-homogenizing region is configured with a second diffractive microstructure layer, the second diffractive microstructure layer is configured to spatially redistribute energy of lights.

Abstract: Described herein are improvements relating to IGF-1 analysis, adjustment and disease management of non-neurological and/or neurological conditions. More specifically, methods relating to the clinical application of cyclic glycine-proline (cGP) biomarker for prediction of risk and recovery of non-neurological and/or neurological conditions with IGF-1 dysfunction and the use of a cGP containing organic or plant based material such as concentrated extract of blackcurrant anthocyanins (BCA) for the treatment of same. The methods more accurately measure IGF-1 function in vivo indirectly using cGP and cGP/IGF-1 ratio along with a means to adjust cGP and cGP/IGF-1 ratio (and hence active IGF-1 concentration), and specific treatment methods for individuals with a lower or reduction of cGP level relative to a standard set of baseline data.

Abstract: A diffractive optical waveguide includes: an optical waveguide substrate, at least one coupling-in grating, at least one relay grating, and at least one coupling-out grating. The coupling-in grating is arranged in the coupling-in region. The relay grating is arranged in the relay region. The coupling-out grating is arranged in the coupling-out region. The relay grating and the coupling-out grating are both two-dimensional gratings. The coupling-in region and the coupling-out region are both symmetrical in shape, the relay grating is symmetrical or asymmetrical in shape. Thus, the relay grating can change a transmission path of part of lights, the lights coupled-in from the coupling-in grating can be transmitted to the coupling-out region through the relay grating and cover the entire coupling-out region, avoiding the problem of dark angle of fields of view in the coupling-out region and improving energy utilization efficiency of the lights.

Abstract: Disclosed are a new interleukin-2 (IL-2) mutant protein and the use thereof. Compared with wild-type IL-2, the IL-2 mutant protein has improved properties, such as an improved IL-2 receptor binding property and improved druggability. Also provided are a fusion protein, dimer and immunoconjugate comprising the IL-2 mutant protein, nucleic acids encoding the IL-2 mutant protein, the dimer and the immunoconjugate, and a vector and host cell comprising the nucleic acid. Further provided are methods for preparing the IL-2 mutant protein, the fusion protein, the dimer and the immunoconjugate, a pharmaceutical composition containing same, and the therapeutic use thereof.

Abstract: An optical combiner and a display device are provided. The optical combiner includes a light-transmitting structure and a waveguide structure in the light-transmitting structure. The waveguide structure includes a first dielectric layer, a waveguide plate, and a second dielectric layer arranged in sequence. The waveguide plate includes a coupling-out region, wherein the refractive index of the first dielectric layer and the refractive index of the second dielectric layer are both less than the refractive index of the waveguide plate. Since the refractive index of the first dielectric layer and the refractive index of the second dielectric layer are both less than the refractive index of the waveguide plate, light beams propagating in the waveguide plate undergo totally reflection during propagation and cannot be refracted into the first dielectric layer and the second dielectric layer.

Abstract: A method of controlling a movable platform may comprise determining a current scene role currently used by a control terminal to control a first movable platform as a first scene role, the first scene role characterizing a first service form currently executed by the first movable platform; automatically selecting a corresponding control function based on the current scene role; after determining that the control terminal has disconnected communication connection with the first movable platform and established a new communication connection with a second movable platform, obtaining a second service form to which the second movable platform belongs; and switching the current scene role currently used by the control terminal from the first scene role corresponding to the first service form to which the first movable platform belongs to a second scene role corresponding to the second service form to which the second movable platform belongs.

Abstract: The present disclosure provides a data acquisition and control system of pulsed power supply for multi-load, and relates to the technical field of pulsed power. The system of the present disclosure is configured to control 18 sets of pulsed power supplies to provide 18 coils with stable and reliable excitation current featuring multiple output time sequences and flexible adjustability, such that a near-earth space plasma environment ground-based simulation device can simulate the magnetic field topology of the earth magnetosphere and realize a background magnetic field required by physical experiments. The system mainly achieves the following functions: control over charge and discharge of pulsed power supplies, selection of power supplies put in use, “delay trigger” setting, voltage monitoring, status monitoring of key components and output current display; and it is also necessary to realize failure alarm and failure handling for the purpose of ensuring the safety of equipment and personnel.

Abstract: A solid dispersion comprising: (a) a pharmaceutical active ingredient or a nutraceutical active ingredient having a low solubility; and (b) sodium or potassium alginate. In addition, a drug dosage form prepared from such a solid dispersion.

Abstract: A nanosuspension comprising (a) a pharmaceutical active ingredient or nutraceutical active ingredient having low solubility; (b) at least one alginate selected from the group consisting of (i) sodium alginate having a viscosity of 100 mPa·s or less in a 1% solution in water at 20° C. and (ii) potassium alginate; and (c) water. Also, a drug dosage form prepared from such a nanosuspension.

Abstract: The present disclosure relates to nanoparticles containing cellular membrane and uses thereof. The nanoparticle comprises an interior compartment (or an inner core) and an outer surface (or shell) comprising a cellular membrane derived from a cell, said interior compartment (or an inner core) not providing a solid support to said cellular membrane in said outer surface (or shell). The present disclosure also relates to processes of making the nanoparticles. The present disclosure further relates to compositions comprising the nanoparticles and methods of using the nanoparticles.

Abstract: Embodiments of the disclosure provide methods and systems for jointly predicting movement trajectories of a plurality of moving objects. The system includes a communication interface configured to receive a map of an area in which the plurality of moving objects are traveling and sensor data acquired associated with the plurality of moving objects. The system further includes at least one processor configured to position the plurality of moving objects in the map. The at least one processor further determines object features of each moving object based on the sensor data, and determines regulation features of the moving objects. The object features characterize movement of the respective moving object, and the regulation features characterize traffic regulations the moving objects need to obey. The at least one processor also jointly predicts the movement trajectories of the plurality of moving objects based on the object features and regulation features using a learning model.

Abstract: Embodiments of the disclosure provide methods and systems for predicting a movement trajectory of a pedestrian. The system includes a communication interface configured to receive a map of an area in which the pedestrian is traveling and sensor data acquired associated with the pedestrian. The system includes at least one processor configured to position the pedestrian in the map, and extract pedestrian features from the sensor data. The at least one processor is further configured to identify one or more objects surrounding the pedestrian based on the positioning of the pedestrian, and extract object features of the one or more objects from the sensor data. The at least one processor is also configured to predict the movement trajectory and a movement speed of the pedestrian based on the extracted pedestrian features and object features using a learning model.

Abstract: Embodiments of the disclosure provide methods and systems for predicting a trajectory of a bicycle ridden by a cyclist. The system includes a communication interface configured to receive a map of an area in which the bicycle is traveling and sensor data acquired associated with the bicycle. The system includes at least one processor configured to position the bicycle in the map, identify the cyclist riding the bicycle, and identify one or more objects surrounding the bicycle based on the positioning of the bicycle. The at least one processor is further configured to extract features of the bicycle, the cyclist, and the one or more objects from the sensor data. The at least one processor is also configured to predict the trajectory of the bicycle based on the extracted features using a learning model.

Abstract: Embodiments of the disclosure provide methods and systems for predicting a trajectory of a vehicle. An exemplary system includes a communication interface configured to receive a map of an area in which the vehicle is traveling and sensor data acquired associated with the vehicle. The system includes at least one processor configured to position the vehicle in the map and identify one or more objects surrounding the vehicle based on the positioning of the vehicle. The at least one processor is further configured to extract features of the vehicle and the one or more objects from the sensor data. The at least one processor is also configured to determine a plurality of candidate trajectories, determine a probability for each candidate trajectory based on the extracted features, and identify the candidate trajectory with the highest probability as the predicted trajectory of the vehicle.

Abstract: Techniques are provided for implementing a probabilistic system and architecture to predict and optimize particular user activity. In one technique, opportunity application data that indicates multiple applications to multiple opportunities is stored. Tracking data that indicates, for each opportunity, a number of reviewer actions with respect to applications to the opportunity is stored. Based on the tracking data, one or more machine learning techniques are used to learn parameters of a model that takes, as input, a number of weighted applications of an opportunity and generates, as output, a prediction of a confirmed hire for the opportunity. A particular opportunity is identified and a first number of reviewer actions with respect to the particular opportunity is determined. A second number of weighted applications for the particular opportunity is generated based on the first number. The second number is input into the model to generate a score for the particular opportunity.