Abstract: Methods, systems, and devices related to digital wireless communication, and more specifically, to techniques related to reporting minimization of driving test (MDT) measurements. In one exemplary embodiment, a method for wireless communication includes receiving a configuration for reducing driving test overhead from a core network node and state information indicating a state of a terminal from a terminal. The method may also include determining the state of the terminal based on the state information indicating the state of the terminal. The method may also include transmitting a measurement report to a network node including the state information indicating the state of the terminal.

Abstract: The present application provides a network information reporting method and apparatus, a user equipment, a service node, and a medium. The network information reporting method includes: detecting, in a case where a user equipment is operating in a first-type network, a cell of a second-type network; and reporting cell network information to a service node of the first-type network, the cell network information including network information corresponding to a detected target cell of the second-type network.

Abstract: Provided is a bispecific fusion protein having a novel structure. A second binding structural domain is inserted into an IgG hinged region in a full length by means of an optional peptide joint. The fusion protein has the same expression and production advantages as those of IgG, does not influence the binding activity of an Fab region of the fusion protein and further improves the stability and obtains a higher half life. In addition, the binding activity of the second binding structural domain to a target binding site is significantly improved with respect to the binding activity of a monomer corresponding to a soluble natural binding fragment to a corresponding target.

Abstract: A system and method for measuring network parameters of a wireless communication network and reporting the measured network parameters to a network node are disclosed herein. In one embodiment, the system and method are configured to determine, by a wireless communication node, at least one parameter related to wireless communication devices in a wireless communication network; compare, by the wireless communication node, the at least one parameter with at least one threshold value; and report, by the wireless communication node, according to an outcome of the comparing, the at least one parameter to a second network node associated with the wireless communication network.

Abstract: Disclosed are a method and apparatus for session offloading, a device, and a storage medium. The method includes following steps: a primary base station determines a session aggregation maximum bit rate (AMBR) of an offloaded session at a secondary base station; and the primary base station sends the session AMBR at the secondary base station to the secondary base station.

Abstract: Provided in the present invention is a PD-L1 immunosuppressant, and specifically provided are a monoclonal antibody capable of targeting PD-L1, and nucleotides, combinations of polynucleotides, expression vectors and combinations of expression vectors encoding the antibody. Also provided in the present invention is a conjugate or pharmaceutical composition containing the above-mentioned anti PD-L1 antibody. Further provided in the present invention is the use of the above-mentioned anti PD-L1 antibody, nucleotides, combinations of polynucleotides, expression vectors, combinations of expression vectors, conjugate or pharmaceutical composition in the preparation of a medicament for treating or preventing cancers.

Abstract: Disclosed is a pharmaceutical formulation containing a mixture of a non-reducing sugar, a TACI-Fc fusion protein and at least one amino acid. The pharmaceutical formulation has the characteristics of reducing particulate matter, reducing aggregate formation, improving the stability, improving the appearance of a freeze-dried powder, etc.

Abstract: Methods, systems, and devices related to mobility robustness in dual connectivity mode are described. In one representative aspect, a method for wireless communication includes receiving, at a master communication node, a first message from a first secondary communication node requesting a change from a first connection to a second connection. The method includes transmitting a second message to the second secondary communication node to request establishing the second connection. The method includes receiving a third message from the mobile device confirming a configuration of the second connection. The method includes receiving a fourth message from the mobile device indicating a failure of the second connection. The method further includes transmitting a fifth message to the first secondary communication node to report that the change from the first connection to the second connection is an improper change.

Abstract: The present invention provides a linker for preparing antibody-drug conjugates and antibody-drug conjugates prepared by the linker, as well as use of the antibody-drug conjugates in a medicament for treating tumor. The linker is capable of coupling simultaneously with the thiol group or amino group on the antibody or functional fragment of the antibody, especially it is capable of coupling with 2, 3 or 4 thiol groups on the antibody or functional fragment of the antibody. A coupled product is uniform and structurally stable.

Abstract: The present invention discloses an antibody drug conjugate that targets MSLN. The present invention also disclosed a method of making the antibody drug conjugate (ADC). The present invention further discloses a novel MSLN antibody or a functional fragment thereof comprising engineered heavy and light chains.

Abstract: The present disclosure an ELISA-based assay that uses a glycosylated polypeptide fragment derived from the SARS-CoV-2 spike protein (Covid-19) receptor binding domain (S1RBD) that has affinity for the extracellular domain of Angiotensin Converting Enzyme 2 (ACE2). The S1RBD polypeptide is generated by expression of an encoding nucleic acid by a human cell expression system resulting in glycosylation of the expressed spike receptor binding domain (S1RBD) protein at least at the N343 N-glycosylation site thereof, and which surprisingly and significantly increases the affinity of the S1RBD for ACE2, provides a significant increase in the sensitivity of the assay compared to other known assays.

Abstract: The present disclosure an ELISA-based assay that uses a glycosylated polypeptide fragment derived from the SARS-CoV-2 spike protein (Covid-19) receptor binding domain (S1RBD) that has affinity for the extracellular domain of Angiotensin Converting Enzyme 2 (ACE2). The S1RBD polypeptide is generated by expression of an encoding nucleic acid by a human cell expression system resulting in glycosylation of the expressed spike receptor binding domain (S1RBD) protein at least at the N343 N-glycosylation site thereof, and which surprisingly and significantly increases the affinity of the S1RBD for ACE2, provides a significant increase in the sensitivity of the assay compared to other known assays.

Abstract: Methods, systems, and devices related to related to digital wireless communication, and more specifically, to techniques related to reporting performance information. In one exemplary aspect, a method for wireless communication includes receiving a performance information report from a terminal, wherein the performance information report includes information relating to performance of the network node. The method also includes initiating a performance task based on receiving the performance information report. In another exemplary aspect, a method for wireless communication includes generating a performance information report that includes information relating to performance of a network node. The method also includes transmitting the performance information report to the network node.

Abstract: A method and apparatus for performing and configuring a performance monitoring is disclosed. In one embodiment, a method for performing a performance monitoring by a wireless communication node of a wireless communication system, includes: receiving a first message from a core network of the wireless communication system; and performing a performance monitoring according to the first message, wherein the first message comprises performance control information of at least one corresponding service flow, wherein the performance control information comprises at least one of the following: a packet delay budget and at least one indicator.

Abstract: The radio access network data volume report method includes that a node acquires data volume information about a data radio bearer, where the data volume information about the data radio bearer includes data volume of a packet data convergence protocol protocol data unit (PDCP PDU) or a packet data convergence protocol service data unit (PDCP SDU) generated by a packet data convergence protocol (PDCP), and data volume of a PDCP PDU or a PDCP SDU issued by the PDCP to radio link control; the node generates a radio access network data volume report according to the data volume information about the data radio bearer; and the node sends the radio access network data volume report to a core network.

Abstract: The present invention relates to an optimized TACI-Fc fusion protein and use of the same in the manufacture of a medicament for treating systemic lupus erythematosus, and a dosage regimen or method for treating systemic lupus erythematosus using the TACI-Fc fusion protein.

Abstract: Described are techniques for providing, a quality of service (QoS) update from a control plane of a base station to a user plane of the base station based on a QoS event, wherein the QoS update includes information indicative of a mapping between a QoS flow and corresponding radio resources for user data transmission, storing, at the user plane, the mapping between the QoS flow and the radio resources, receiving, at the user plane, a downstream data packet of the QoS flow from a core network, and transmitting the downstream data packet in a downlink direction using the corresponding radio resources.

Abstract: Provided are a handover method and device involving multiple core networks. The method includes: transmitting, by a first base station, a handover request message to a second base station directly transmitting or through a core network; receiving, by the first base station, a feedback message from the core network or the second base station, where the feedback message carries at least one of: information about a core network suggested to be handed over, a failure reason.

Abstract: In one aspect a wireless communications method is disclosed. The method includes receiving, at the first base station, an activation message to allow the first base station to receive the network performance information from a user equipment. The method further includes selecting the user equipment from a plurality of user equipment based on allowed network performance information. The method further includes sending, from the first base station to the user equipment, a configuration message including a configuration for the network performance information that includes the allowed network performance information.

Abstract: The present invention relates to a bifunctional angiogenesis inhibitor, which has VEGF inhibitory activity and FGF inhibitory activity, and can inhibit VEGF and FGF dual factors-induced or high glucose-induced cell proliferation, cell migration, and/or lumen formation. The present invention also relates to the use of the bifunctional angiogenesis inhibitor in inhibiting retinal angiogenesis, such as diabetic retinopathy, age-related macular degeneration and the like.