Abstract: Bifidobacterium longum subsp. infantis CCFM687, a fermented food thereof, and an application of the same in preparing a drug, health care product, or food against depression, autism, inflammatory bowel disease, obesity, or type 1 diabetes.

Abstract: The disclosure discloses Bacteroides ovatus for relieving endotoxin infection and application thereof, and belongs to the technical field of microorganisms. The Bacteroides ovatus CCFM1021 of the disclosure has low immunogenicity, and can reduce the content of pro-inflammatory factors and increase the concentration of anti-inflammatory factors in the blood of mice infected with endotoxin, up-regulate the number of Foxp3+ regulatory T cells and stabilize the composition of the intestinal microbiota. A pharmaceutical composition of the Bacteroides ovatus CCFM1021 for relieving endotoxin infection has broad application prospects.

Abstract: The disclosure discloses a strain of Lactobacillus rhamnosus and application thereof in inhibiting Helicobacter pylori, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain of Lactobacillus rhamnosus CCFM1119. The Lactobacillus rhamnosus CCFM1119 can prevent and/or treat Helicobacter pylori infection, specifically embodied in that: (1) the Lactobacillus rhamnosus CCFM1119 can significantly relieve the gastrointestinal symptoms of patients with Helicobacter pylori infection; (2) the Lactobacillus rhamnosus CCFM1119 can significantly reduce the amount of colonization of Helicobacter pylori in patients with Helicobacter pylori infection; and (3) the Lactobacillus rhamnosus CCFM1119 can significantly increase the clearance rate of Helicobacter pylori in patients with Helicobacter pylori infection.

Abstract: An optical system of a stereo-video endoscope with a sideways viewing direction, the optical system including: a sideways-viewing distal optical assembly; and a proximal optical assembly; wherein the distal optical assembly includes an inlet lens, a deflecting unit configured as a prism unit, and an outlet lens on a common optical axis one after the other in the direction of light incidence, the proximal optical assembly includes a left and a right lens system channel, the lens system channels being identically configured and arranged parallel to each other, each lens system channel having its own optical axis, and the outlet lens is formed with one or more of a light-impermeable coating on a light inlet side facing the deflecting unit and with a light-impermeable coating formed on a light outlet side facing away from the deflecting unit in a central region of the outlet lens.

Abstract: The disclosure discloses a strain of Lactobacillus crispatus capable of preventing and/or treating Helicobacter pylori infection, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain of Lactobacillus crispatus CCFM1118. The Lactobacillus crispatus CCFM1118 can inhibit Helicobacter pylori, specifically embodied in that: (1) the diameter of an inhibition zone of supernatant of the Lactobacillus crispatus CCFM1118 on Helicobacter pylori can reach 13.14 mm; and (2) the Lactobacillus crispatus CCFM1118 can significantly reduce the adhesion of Helicobacter pylori to AGS cells. Therefore, the Lactobacillus crispatus CCFM1118 has great application prospects in inhibiting Helicobacter pylori (not for the purposes of disease diagnosis and treatment) and preparing Helicobacter pylori inhibitors.

Abstract: The disclosure discloses a B. breve strain capable of relieving rheumatoid arthritis and application thereof, and belongs to the technical field of microorganisms. The disclosure screens out a B. breve strain CCFM1078, and the B. breve CCFM1078 has the effect of relieving rheumatoid arthritis, being specifically embodied in: significantly promoting secretion of anti-inflammatory factor IL-10 from RAW264.7 cells; significantly reducing the joint thickness, clinical score and incidence of rats with rheumatoid arthritis; significantly decreasing the levels of pro-inflammatory cytokines TNF? and IL-1? in the serum of rats with rheumatoid arthritis; significantly regulating the content of short-chain fatty acids in the feces of rats with rheumatoid arthritis; significantly decreasing the proportion of Th17 cells in the mesenteric lymph nodes of rats with rheumatoid arthritis; and significantly reducing secretion of pro-inflammatory factor IL-6 from synovial cells.

Abstract: The disclosure discloses a probiotic mixed preparation with anti-influenza ability and application thereof, and belongs to the technical fields of microorganisms and medicines. The probiotic mixed preparation has anti-influenza effects, which are embodied in: (1) significantly reducing the degree of weight loss of influenza mice; (2) significantly improving the blood indexes of the influenza mice; (3) significantly improving the inflammation status of respiratory tract infections in the influenza mice; (4) significantly reducing the viral load in the lungs of the influenza mice (i.e., significantly inhibiting the replication and multiplication of influenza viruses in the influenza mice); and (5) significantly increasing the expression quantity of antiviral protein MxA in the lungs of the influenza mice. Therefore, the probiotic mixed preparation has great application prospects in preparation of a product for preventing and/or treating atopic dermatitis and even preventing and/or treating influenza.

Abstract: An optical system for use with a stereo video endoscope with a fixed lateral viewing direction. The optical system including: a laterally-viewing distal optical assembly; and a proximal optical assembly, the distal optical assembly and proximal optical assembly jointly establishing a beam path, the proximal optical assembly including: a left channel lens system; and a right channel lens system similarly configured to the left channel lens system; wherein the distal optical assembly establishes an optical axis and is configured to couple incident light along the beam path from an object space into the left channel lens system and into the right channel lens system of the proximal optical assembly; and the optical system comprises an angle-selective optical element with a surface oriented perpendicular to the optical axis of the distal optical assembly, the surface being located in the beam path and coated with an incidence-angle-selective dielectric coating.

Abstract: An optical system for a stereo video endoscope including: first and second lens system channels each having optical elements in identical configurations, the optical elements being arranged in a same position along first and second optical axes, respectively, an optical axis of first and second optical elements coincide with the first and second optical axes, respectively, first and second cross-sectional areas of the first and second optical elements are inscribed in first and second circumferential circles, respectively, centers of first and second circumferential circles each coincide with the first and second optical axes, respectively, to define a maximum radius of the first optical element and the second optical element, the first and second circumferential circles overlap one another, and circumferential shapes of the first and second optical elements deviate from the first and second circumferential circles circumscribing them such that the first and second optical elements do not contact.

Abstract: The present disclosure discloses multifunctional lactobacilli capable of relieving a toxic effect of perfluorooctanoic acid (PFOA) and use thereof, and belongs to the technical field of microorganisms.

Abstract: An optical system for use with a stereo video endoscope with a fixed, lateral viewing direction, including: laterally-viewing distal and proximal optical assemblies, similarly configured left and right lens system channels; the distal optical assembly couples incident light from an object space into the left and right lens system channels; the distal optical assembly includes an entrance lens, a deflection prism group and an exit lens in a direction of incident light; the deflection prism group includes first and second prisms in the direction of incident light; the first prism includes first entrance and first exit sides at an angle relative thereto; the second prism includes a second entrance side, a reflection side and a second exit side; and the first entrance side of the first prism and the reflection side of the second prism enclose an angle that is greater than a total reflection angle of the second prism.

Abstract: The present disclosure relates to the field of microbial technology, and discloses a probiotic composition and use thereof. The probiotic composition in the present disclosure is consisted of Bifidobacterium adolescentis CCFM8630, Lactobacillus reuteri CCFM8631 and Lactobacillus rhamnosus CCFM1044, whose effect of alleviating metabolic syndrome is significantly better than that of CCFM8630 or CCFM8631 alone or combination of the two, especially in aspects of lowering epididymal fat content, lowering fasting blood glucose level, lowering the area under sugar tolerance curve and lowering contents of serum low density lipoprotein and total cholesterol, improving liver antioxidant capacity and lowering serum IL-1? content, etc. The extent of decrease or increase is increased by 9.62% to 769.62% compared with formulations of a single probiotic or a combination of two probiotics. The combination of three probiotics achieves a significant synergistic effect.

Abstract: The present invention relates to the technical field of microbes, in particular to a Lactobacillus plantarum which can significantly inhibit the occurrence of colorectal cancer, and its use thereof. The Lactobacillus plantarum strain CCFM164 has a deposit number CGMCC No. 14520, which has a good tolerance to gastric acid and bile salts, significantly alleviate the level of colorectal inflammation in colorectal cancer model mice, and can reduce the number of tumors in the colon and rectum of the model mice by regulating the Notch1, Notch2 signaling pathway and the expression of VEGFR2 molecule in colorectal tissue. In addition, the Lactobacillus plantarum CCFM164 can also improve the intestinal flora population and short-chain fatty acid levels in the intestine. The Lactobacillus plantarum CCFM164 is used to prepare a fermented food for the inhibition of the occurrence of colorectal cancer with wild applications.

Abstract: The disclosure discloses P. acidilactici CCFM6432 for alleviating depression, food fermented thereby and application thereof. The P. acidilactici CCFM6432 of the disclosure can be used to prepare food, health-care products and drugs with the functions of resisting depression, resisting inflammation, resisting inflammatory bowel disease, resisting obesity and resisting type I diabetes. The disclosure further provides fermented food. The fermented food is produced by fermentation using the P. acidilactici CCFM6432, and the fermented food includes solid food, liquid food, and semi-solid food. The P. acidilactici CCFM6432 has very broad application prospects.

Abstract: Disclosed is linoleic acid isomerases and their application in production of conjugated linoleic acid, which belongs to the technical fields of protein engineering and microbial engineering. The linoleic acid isomerase derived from Bifidobacterium is used to produce the conjugated linoleic acid. The recombinant E. coli containing the linoleic acid isomerase of the invention is added into a reaction system containing linoleic acid and react for 3 h to produce conjugated linoleic acids. The conversion rate of the conjugated linoleic acid of the invented method ranges from 12.1% to 42.1%, and the percentage of cis9, trans11-CLA in the conjugated linoleic acid can reach 84.3% to 89.1%. The invention provides a method for using microorganisms to produce conjugated linoleic acids with high safety and yield where cis9, trans11-CLA isomer is the major form in the conjugated linoleic acid products.

Abstract: A stereo endoscope including: a shaft; and an objective lens including: a distal objective lens portion, where beam paths of right and left partial images extend through common optical components; a proximal objective lens portion, where the beam paths of the right and left partial images extend through separate optical components; and a transition portion, where the beam paths of the right and left partial images, which emerge from the distal objective lens portion at an angle to one another, are aligned parallel to one another; the transition portion comprises a lateral spreading arrangement including optical components for increasing a distance between the beam paths of the right and left partial images; and the lateral spreading arrangement is configured to laterally spread the beam paths of the right and left partial images asymmetrically in relation to an optical axis of the distal objective lens portion.

Abstract: The disclosure herein discloses L. plantarum CCFM1019, fermented foods thereof, and application thereof in preparation of a medicine for promoting excretion of plasticizers and metabolites thereof from the body. The L. plantarum CCFM1019 not only is significantly better than the intestinal resident bacteria E. coli and E. faecalis in terms of the effect of promoting the excretion of DEHP and MEHP, but also is better than the commercial strain L. rhamnosus LGG. Therefore, the L. plantarum CCFM1019 of the disclosure can be used as an effective means to prevent and alleviate body damage caused by DEHP and MEHP, and has no toxic side effects of drugs. L. plantarum CCFM1019 can be used to prepare pharmaceutical compositions and fermented foods for alleviating and preventing the toxicity of DEHP and metabolites thereof, and has a very broad application prospect.

Abstract: Disclosed is a diacylglycerol acyltransferase 1, a recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1, and application thereof in production of triacylglycerol. The diacylglycerol acyltransferase 1 of the invention has a function of catalyzing synthesis of triacylglycerol. After the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 of the invention is subjected to induction culture for 48 h, the content of total fatty acid and triacylglycerol in the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 can be respectively increased by 1.94 folds and 12.09 folds as compared with those of Saccharomyces cerevisiae without the recombinant diacylglycerol acyltransferase 1. The instant invention provides a method for improving the ability of microorganisms to produce polyunsaturated fatty acids (PUFAs) by means of genetic engineering.

Abstract: An optical system including: a distal optical assembly; a proximal optical assembly; and an image sensor; wherein the distal and proximal optical assemblies define a beam path; the distal optical assembly couples incident beams of light from a field of view located in an object space in the proximal optical assembly; the proximal optical assembly directs the incident beams of light onto a light-sensitive surface of the image sensor; and at least one of the distal and proximal optical assemblies comprise, at least one prism arranged in the beam path, such that the at least one prism limits the field of view of the optical system on at least one side.

Abstract: The disclosure discloses P. pentosaceus CCFM1012, fermented food thereof and application thereof to preparation of a C. jejuni infection antagonism medicine. The P. pentosaceus CCFM1012 of the disclosure can remarkably reduce a colonization rate of in-vivo C. jejuni of mice infected with C. jejuni and transcriptional activity of virulence genes flaA, cadF, cdtB, cdtC and dnaJ of the C. jejuni, can effectively relieve physiological damage caused by infection of the C. jejuni, can also be used for preparing dairy products, bean products and fruit and vegetable fruits for preventing infection of the C. jejuni and an additive that can be added to a poultry and livestock feed for reducing infection and carrying of the C. jejuni in poultry and livestock, and has quite broad application prospects.