Patents by Inventor Jiawei Yao

Jiawei Yao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GLP1R
    Publication number: 20230363362
    Abstract: This disclosure relates to genetically modified animal expressing human or chimeric (e.g., humanized) GLP1R, and methods of use thereof.
    Type: Application
    Filed: September 17, 2021
    Publication date: November 16, 2023
    Inventors: Yuelei Shen, Jiawei Yao, Yanan Guo, Yang Bai, Chengzhang Shang
  • Genetically modified non-human animals with humanized immunoglobulin locus
    Patent number: 11730151
    Abstract: The present disclosure relates to genetically modified animals and cells with humanized heavy chain immunoglobulin locus and/or humanized light chain immunoglobulin locus.
    Type: Grant
    Filed: October 12, 2022
    Date of Patent: August 22, 2023
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Jiawei Yao, Huizhen Zhao, Yabo Zhang, Lili Liu, Hui Lu, Shuwen Huang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL EXPRESSING A B2M/FCRN FUSION PROTEIN
    Publication number: 20230227531
    Abstract: The present disclosure relates to genetically modified non-human animals that express a fusion protein including B2M and FcRn, and methods of use thereof. In some embodiments, the animals can have a B-NDG background. In some embodiments, the endogenous B2M gene is knocked out in the animals.
    Type: Application
    Filed: June 18, 2021
    Publication date: July 20, 2023
    Inventors: Yuelei Shen, Jiawei Yao, Yanan Guo, Yang Bai, Chengzhang Shang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD276
    Publication number: 20230165227
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD276, and methods of use thereof.
    Type: Application
    Filed: May 21, 2021
    Publication date: June 1, 2023
    Inventors: Yuelei Shen, Yang Bai, Jiawei Yao, Yanan Guo, Lei Zhao
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD38
    Publication number: 20230148574
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD38, and methods of use thereof.
    Type: Application
    Filed: April 1, 2021
    Publication date: May 18, 2023
    Inventors: Yuelei Shen, Yang Bai, Jiawei Yao, Yanan Guo, Lei Zhao
  • GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH COMMON LIGHT CHAIN IMMUNOGLOBULIN LOCUS
    Publication number: 20230128645
    Abstract: This disclosure relates to genetically modified animals and cells with humanized light chain immunoglobulin locus and/or humanized heavy chain immunoglobulin locus. In one aspect, the endogenous light chain immunoglobulin locus comprises a limit number of human IGKV genes and human IGKJ genes.
    Type: Application
    Filed: October 19, 2022
    Publication date: April 27, 2023
    Inventors: Yabo Zhang, Hui LU, Huizhen ZHAO, Jiawei Yao, Yi Yang, Yuelei Shen
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC MHC PROTEIN COMPLEX
    Publication number: 20230072216
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) major histocompatibility complex (MHC) protein complex, and methods of use thereof.
    Type: Application
    Filed: January 8, 2021
    Publication date: March 9, 2023
    Inventors: Yuelei Shen, Chaoshe Guo, Meiling Zhang, Rui Huang, Yanan Guo, Yang Bai, Jiawei Yao, Chengzhang Shang
  • GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH HUMANIZED IMMUNOGLOBULIN LOCUS
    Publication number: 20230064196
    Abstract: The present disclosure relates to genetically modified animals and cells with humanized heavy chain immunoglobulin locus and/or humanized light chain immunoglobulin locus.
    Type: Application
    Filed: October 12, 2022
    Publication date: March 2, 2023
    Inventors: Yuelei Shen, Jiawei Yao, Huizhen ZHAO, Yabo ZHANG, Lili Liu, Hui LU, Shuwen HUANG
  • GENETICALLY MODIFIED IMMUNODEFICIENT NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPa/CD47
    Publication number: 20230058049
    Abstract: This disclosure relates to genetically modified immunodeficient animals which express a human or chimeric (e.g., humanized) SIRP? and/or human or chimeric (e.g., humanized) CD47, and methods of use thereof.
    Type: Application
    Filed: December 31, 2020
    Publication date: February 23, 2023
    Inventors: Yuelei Shen, Yang Bai, Jiawei Yao, Chaoshe Guo, Meiling Zhang, Rui Huang, Yanan Guo, Chengzhang Shang
  • HUMANIZED TRANSGENIC ANIMAL
    Publication number: 20230043907
    Abstract: Provided are a humanized transgenic non-human animal, especially a rodent, in particular a transgenic mouse containing a human interleukin 17A (IL-17A) gene, a human gene 17RA (IL-17RA) and/or a human TNF-alpha gene, and a preparation method therefor and the use thereof.
    Type: Application
    Filed: August 1, 2022
    Publication date: February 9, 2023
    Inventors: Yuelei Shen, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao, Xiaofei Zhou, Meiling Zhang, Jiawei Yao
  • Genetically modified non-human animal with human or chimeric LAG3
    Patent number: 11564381
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) LAG3, and methods of use thereof.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: January 31, 2023
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Jiawei Yao, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao, Meiling Zhang
  • GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH HUMAN OR CHIMERIC THPO
    Publication number: 20220408704
    Abstract: The present disclosure relates to genetically modified non-human animals expressing human or chimeric (e.g., humanized) Thrombopoietin (THPO), and methods of use thereof.
    Type: Application
    Filed: October 30, 2020
    Publication date: December 29, 2022
    Inventors: Yuelei Shen, Rui Huang, Yanan Guo, Yang Bai, Jiawei Yao, Chaoshe Guo, Meiling Zhang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC GENES
    Publication number: 20220378025
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL10R and/or a human or chimeric (e.g., humanized) IL10, and methods of use thereof.
    Type: Application
    Filed: November 11, 2020
    Publication date: December 1, 2022
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Jiawei Yao, Chaoshe Guo, Meiling Zhang, Rui Huang, Lei Zhao, Xiaofei Zhou
  • Genetically modified non-human animal with human or chimeric OX40
    Patent number: 11505806
    Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric OX40, and methods of use thereof.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: November 22, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Chaoshe Guo, Yang Bai, Jiawei Yao, Meiling Zhang, Xiaofei Zhou
  • Genetically modified mice expressing humanized CD40
    Patent number: 11497198
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD40, and methods of use thereof.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: November 15, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Chaoshe Guo, Rui Huang, Lei Zhao, Yanan Guo, Yang Bai, Meiling Zhang, Jiawei Yao
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC TNFR2
    Publication number: 20220346357
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) TNFR2, and methods of use thereof.
    Type: Application
    Filed: September 4, 2020
    Publication date: November 3, 2022
    Inventors: Yuelei Shen, Rui Huang, Yanan Guo, Yang Bai, Lei Zhao, Jiawei Yao, Chaoshe Guo, Meiling Zhang
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC IL2RA
    Publication number: 20220312749
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL2RA, and methods of use thereof.
    Type: Application
    Filed: August 7, 2020
    Publication date: October 6, 2022
    Inventors: Yuelei Shen, Yang Bai, Chengzhang Shang, Rui Huang, Meiling Zhang, Jiawei Yao, Chaoshe Guo, Yanan Guo
  • Humanized transgenic animal
    Patent number: 11439132
    Abstract: Provided are a humanized transgenic non-human animal, especially a rodent, in particular a transgenic mouse containing a human interleukin 17A (IL-17A) gene, a human gene 17RA (IL-17RA) and/or a human TNF-alpha gene, and a preparation method therefor and the use thereof.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: September 13, 2022
    Assignee: Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
    Inventors: Yuelei Shen, Chaoshe Guo, Yanan Guo, Yang Bai, Rui Huang, Lei Zhao, Xiaofei Zhou, Meiling Zhang, Jiawei Yao
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC IL33
    Publication number: 20220272953
    Abstract: Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL33, and methods of use thereof.
    Type: Application
    Filed: July 29, 2020
    Publication date: September 1, 2022
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Chengzhang Shang, Rui Huang, Meiling Zhang, Jiawei Yao, Chaoshe Guo
  • GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD73
    Publication number: 20220211019
    Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD73, and methods of use thereof.
    Type: Application
    Filed: November 20, 2019
    Publication date: July 7, 2022
    Inventors: Yuelei Shen, Yanan Guo, Yang Bai, Rui Huang, Chengzhang Shang, Meiling Zhang, Jiawei Yao, Chaoshe Guo