Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

Abstract: A test piece holder for coalbed fracturing comprises a pressure chamber, first sliding rods, second sliding rods, third sliding rods, fourth sliding rods, fifth sliding rods, oil cylinders and a sealing ring, upper and lower ends of a test piece are both provided with an electrode needle and a gas-guide and liquid-guide conducting bolt, the gas-guide and liquid-guide conducting bolt has a hollow rod structure, an inside end of the gas-guide and liquid-guide conducting bolt located above is communicated with a water-gas channel and an outside end of the gas-guide and liquid-guide conducting bolt located above is a water-gas outlet, an inside end of the gas-guide and liquid-guide conducting bolt located below is communicated with the water-gas channel and an outside end of the gas-guide and liquid-guide conducting bolt located below is respectively provided with a gas inlet and a water inlet.

Abstract: Disclosed is a real-time nondestructive observation and two-phase seepage test system for a fracture of an in-situ fractured gas-bearing reservoir, which comprises a stress loading system, a high-voltage electric pulse fracturing operation system, a water-gas two-phase seepage system and an in-situ CT scanning system; the stress loading system comprises a pressure chamber, an axial pressure loading module and a confining pressure loading module; the high-voltage electric pulse fracturing operation system comprises a high-voltage electric pulse generation module, a high-voltage electric pulse signal monitoring module and a protection module; the water-gas two-phase seepage system comprises a water-gas pressure loading module and a flow data acquisition module; and the in-situ CT scanning system comprises a radiation source, a flat panel detector and a CT scanning detection mechanism.

Abstract: The present invention provides a yieldable construction method for early releasing surrounding rock deformation on a weak toppling slope, thereby reducing surrounding rock toppling deformation risk in and after an excavation process and ensuring overall slope stability and safety of a supporting structure. A technical solution of the present invention is as follows: loosing a rock mass through controlled blasting; inducing toppling deformation of the slope by injecting water and softening a blasting relaxation part of the rock mass; determining timing of water injection by monitoring slope surface displacement characteristics of the slope; and performing a normal excavation process of the toppling deformation slope after injecting is completed. The present invention is applicable to design and construction of high slope engineering of a special kind of rocks, i.e., a toppling deformation slope composed of weak rock masses.

Abstract: The present invention provides a yieldable construction method for early releasing surrounding rock deformation on a weak toppling slope, thereby reducing surrounding rock toppling deformation risk in and after an excavation process and ensuring overall slope stability and safety of a supporting structure. A technical solution of the present invention is as follows: loosing a rock mass through controlled blasting; inducing toppling deformation of the slope by injecting water and softening a blasting relaxation part of the rock mass; determining timing of water injection by monitoring slope surface displacement characteristics of the slope; and performing a normal excavation process of the toppling deformation slope after injecting is completed. The present invention is applicable to design and construction of high slope engineering of a special kind of rocks, i.e., a toppling deformation slope composed of weak rock masses.