Patents by Inventor Jie Lian

Jie Lian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9406449
    Abstract: Supercapacitors have composite electrodes that include a porous carbonaceous material such as graphene onto which a metal oxide pseudocapacitor material is deposited in the form of nano-scale particles or a nano-scale film. The composite electrodes exhibit excellent specific capacitance, even at high scan rates.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: August 2, 2016
    Assignee: Regents of the University of Colorado, a Body Corporate
    Inventors: Ming Xie, Steven M. George, Mattias J. Young, Xiang Sun, Jie Lian, Gongkai Wang
  • Patent number: 9383256
    Abstract: A UV exposure dosimetry system includes at least one UV sensor that accurately measures the UV irradiance intensity. The system can generate extrapolated UV intensity data based on measured UV intensity data to correct unreliable UV measurement due to inconsistent irradiation of UV light. The UV dosimetry system integrates the extrapolated UV intensity data over time to calculate the real-time UV dosage and the vitamin D production by taking into account factors comprising UV sensor location, body surface area, clothing coverage, and sunscreen usage. Based on the measurement, the system can predict the time remaining to skin burn and the time remaining to reach daily goal of vitamin D production. The UV dosimetry system supports multi-user control through an advanced and user friendly input and output interface.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: July 5, 2016
    Inventors: Jie Lian, Nabyl Bennouri, Nattapon Chaimanonart
  • Patent number: 9383255
    Abstract: A UV exposure dosimetry system includes at least one UV sensor that accurately measures the UV irradiance intensity. The UV dosimetry system integrates the measured UV irradiance intensity over time to calculate the real-time UV dosage and the vitamin D production by taking into account factors comprising UV sensor location, body surface area, clothing coverage, and sunscreen usage. Based on the measurement, the system can predict the time remaining to skin burn and the time remaining to reach daily goal of vitamin D production. The system also calculates the UV index in real-time, and can crowd source the measured data in a network. The UV dosimetry system supports multi-user control through an advanced and user friendly input and output interface.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: July 5, 2016
    Inventors: Jie Lian, Nabyl Bennouri, Nattapon Chaimanonart
  • Publication number: 20160175595
    Abstract: An implantable pulse generator system includes a stimulation unit delivering vagal nerve stimulation pulses, an activity sensor determining an exertion level of the user and generating a signal representing metabolic demand, an autonomic tone sensor determining an autonomic status of the user and generating a signal representing autonomic status, and a control unit in communication with the foregoing components, and which is adapted to control the stimulation unit depending on both the signal representing metabolic demand and the signal representing autonomic status.
    Type: Application
    Filed: December 8, 2015
    Publication date: June 23, 2016
    Inventors: Jie Lian, Lauren Kraiter, Alan Fryer, Andrew B. Kibler, Dirk Muessig, Larry Stotts, Warren Dabney, Jeffrey A. von Arx
  • Patent number: 9295428
    Abstract: A method of enhancing the signal-to-noise ratio (SNR) of measured electrocardiogram (ECG) signals is provided. The method includes the steps of providing at least three cardiac input signals derived from the measured ECG signals S1 and forming a first estimate U1 S2 from each of at least three pairs of input signals. Moreover, the method includes the steps of forming a second estimate U2 S3 from each of at least three input signals; comparing S4 the polarity and the amplitude of a first and second estimate U1, U2 to at least one threshold T; generating S5 a composite signal X, wherein the polarity and the amplitude of the composite signal X depend on the result of the comparison; and using S6 the generated composite signal X to produce an output signal with enhanced signal-to-noise ratio (SNR). Furthermore, a corresponding cardiac device is also provided.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: March 29, 2016
    Assignee: BIOTRONIK SE & Co. KG
    Inventors: Jie Lian, Garth Garner, Dirk Müssig
  • Publication number: 20150374296
    Abstract: A nerve cuff stimulation electrode for cervical VNS is provided and configured to be arranged so as to at least partially surround or enclose one of the vagus nerves. The cuff stimulation electrode has at least two contacts configured to deliver electric stimulation pulses to a vagus nerve. The cuff stimulation electrode further has or may be attached or connected to a tilt sensor, a kinematic sensor, and/or a pulsation sensor configured to generate a signal representative of arterial and venous pressures. The implantable tilt sensor is configured to output a posture signal indicating a patient's posture, thus allowing discrimination between supine and semi-recumbent or erect postures.
    Type: Application
    Filed: June 22, 2015
    Publication date: December 31, 2015
    Applicant: BIOTRONIK SE & Co. KG
    Inventors: Marcelo BARU, Andrew B. KIBLER, Warren DABNEY, Jie LIAN, Christopher MOULDER, Dirk MUESSIG
  • Patent number: 9211414
    Abstract: Exemplary versions of the invention include methods and apparatuses for assessing ventricular activation time by determining a point in time t1 of an initial positive deflection on a far-field electrogram and a point in time t2 of a first peak of the negative deflection on a near-field electrogram of a same heart cycle. They also determine a time difference between points in time t1 and t2 said time difference representing the ventricular activation time. A progression of ventricular conduction disorders such as the left bundle branch block (LBBB) and the right bundle branch block (RBBB) can be monitored. Trending analysis of the ventricular activation time provides a means for monitoring the progression of ventricular conduction diseases.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: December 15, 2015
    Assignee: BIOTRONIK SE & CO KG
    Inventors: Jie Lian, Dirk Muessig
  • Patent number: 9116045
    Abstract: A UV exposure dosimetry system includes at least one UV sensor that accurately measures the UV irradiance intensity. The UV dosimetry system integrates the measured UV irradiance intensity over time to calculate the real-time UV dosage and the vitamin D production by taking into account factors comprising UV sensor location, body surface area, clothing coverage, and the effective sun protection factor of the applied sunscreen. Based on the measurement, the system can predict the time remaining to skin burn and the time remaining to reach daily goal of vitamin D production. The UV dosimetry system supports multi-user control through an advanced and user friendly input and output interface.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: August 25, 2015
    Inventors: Jie Lian, Nabyl Bennouri, Nattapon Chaimanonart
  • Patent number: 9086323
    Abstract: A UV exposure dosimetry system includes at least one UV sensor that accurately measures the UV irradiance intensity. The UV dosimetry system integrates the measured UV irradiance intensity over time to calculate the real-time UV dosage and the vitamin D production by taking into account factors comprising UV sensor location, body surface area, clothing coverage, and sunscreen usage. Based on the measurement, the system can predict the time remaining to skin burn and the time remaining to reach daily goal of vitamin D production. The system also calculates the UV index in real-time, and can crowd source the measured data in a network. The UV dosimetry system supports multi-user control through an advanced and user friendly input and output interface.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: July 21, 2015
    Inventors: Jie Lian, Nabyl Bennouri, Nattapon Chaimanonart
  • Patent number: 9068887
    Abstract: A UV dosimetry system comprises a wearable unit and a mobile computing device. The wearable unit measures the UV irradiance intensity and wirelessly communicates with the mobile computing device. The UV dosimetry system supports multi-user control and can link one mobile computing device with multiple wearable units. The UV dosimetry system processes the measured UV irradiance intensity to calculate the UV index (UVI) and the sensor site specific UV dose. It can also calculate the total absorbed UV dose and vitamin D production by taking into account user specific factors. The UVI data measured by a plurality of UV meters such as the disclosed UV dosimetry system are crowd sourced to a remote server together with the location and time data of the measurement. The remote server excludes invalid UVI measurement and generates UVI maps showing time-varying distribution of UVI data at different locations.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: June 30, 2015
    Inventors: Nabyl Bennouri, Jie Lian, Nattapon Chaimanonart
  • Publication number: 20150177057
    Abstract: A UV exposure dosimetry system includes at least one UV sensor that accurately measures the UV irradiance intensity. The UV dosimetry system integrates the measured UV irradiance intensity over time to calculate the real-time UV dosage and the vitamin D production by taking into account factors comprising UV sensor location, body surface area, clothing coverage, and sunscreen usage. Based on the measurement, the system can predict the time remaining to skin burn and the time remaining to reach daily goal of vitamin D production. The system also calculates the UV index in real-time, and can crowd source the measured data in a network. The UV dosimetry system supports multi-user control through an advanced and user friendly input and output interface.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 25, 2015
    Inventors: Jie Lian, Nabyl Bennouri, Nattapon Chaimanonart
  • Publication number: 20150177063
    Abstract: A UV exposure dosimetry system includes at least one UV sensor that accurately measures the UV irradiance intensity. The system can generate extrapolated UV intensity data based on measured UV intensity data to correct unreliable UV measurement due to inconsistent irradiation of UV light. The UV dosimetry system integrates the extrapolated UV intensity data over time to calculate the real-time UV dosage and the vitamin D production by taking into account factors comprising UV sensor location, body surface area, clothing coverage, and sunscreen usage. Based on the measurement, the system can predict the time remaining to skin burn and the time remaining to reach daily goal of vitamin D production. The UV dosimetry system supports multi-user control through an advanced and user friendly input and output interface.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 25, 2015
    Inventors: Jie Lian, Nabyl Bennouri, Nattapon Chaimanonart
  • Publication number: 20150177055
    Abstract: A UV exposure dosimetry system includes at least one UV sensor that accurately measures the UV irradiance intensity. The UV dosimetry system integrates the measured UV irradiance intensity over time to calculate the real-time UV dosage and the vitamin D production by taking into account factors comprising UV sensor location, body surface area, clothing coverage, and sunscreen usage. Based on the measurement, the system can predict the time remaining to skin burn and the time remaining to reach daily goal of vitamin D production. The system can also provide feedback to the user of the device based on a composite metric assessing the degree of balance between the risk of UV exposure and the benefit of UV exposure. The UV dosimetry system supports multi-user control through an advanced and user friendly input and output interface.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 25, 2015
    Inventors: Jie Lian, Nabyl Bennouri, Nattapon Chaimanonart
  • Publication number: 20150177058
    Abstract: A UV exposure dosimetry system includes at least one UV sensor that accurately measures the UV irradiance intensity. The UV dosimetry system integrates the measured UV irradiance intensity over time to calculate the real-time UV dosage and the vitamin D production by taking into account factors comprising UV sensor location, body surface area, clothing coverage, and the effective sun protection factor of the applied sunscreen. Based on the measurement, the system can predict the time remaining to skin burn and the time remaining to reach daily goal of vitamin D production. The UV dosimetry system supports multi-user control through an advanced and user friendly input and output interface.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 25, 2015
    Inventors: Jie Lian, Nabyl Bennouri, Nattapon Chaimanonart
  • Publication number: 20150177056
    Abstract: A UV exposure dosimetry system includes at least one UV sensor that accurately measures the UV irradiance intensity. The UV dosimetry system integrates the measured UV irradiance intensity over time to calculate the real-time UV dosage and the vitamin D production by taking into account factors comprising UV sensor location, body surface area, clothing coverage, and sunscreen usage. Based on the measurement, the system can predict the time remaining to skin burn and the time remaining to reach daily goal of vitamin D production. The system also calculates the UV index in real-time, and can crowd source the measured data in a network. The UV dosimetry system supports multi-user control through an advanced and user friendly input and output interface.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 25, 2015
    Inventors: Jie Lian, Nabyl Bennouri, Nattapon Chaimanonart
  • Publication number: 20150177059
    Abstract: A UV exposure dosimetry system includes at least one UV sensor that accurately measures the UV irradiance intensity. The UV dosimetry system integrates the measured UV irradiance intensity over time to calculate the real-time UV dosage and the vitamin D production by taking into account factors comprising UV sensor location, body surface area, clothing coverage, and sunscreen usage. Based on the measurement, the system can predict the time remaining to skin burn and the time remaining to reach daily goal of vitamin D production. The system can also estimate UV intensity for a time in the future at a geographic location based on the forecast UV index data, and predict UV dose and vitamin D generation for the user corresponding to user defined scenarios. The UV dosimetry system supports multi-user control through an advanced and user friendly input and output interface.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 25, 2015
    Inventors: Jie Lian, Nabyl Bennouri, Nattapon Chaimanonart
  • Patent number: 9050013
    Abstract: A heart monitoring and/or therapy device for detecting and quantifying fusion beats, wherein the device includes an IEGM signal sensing channel that puts out a recorded IEGM signal and an evaluation unit operatively connected to the IEGM signal sensing channel that detects fusion beats. The evaluation unit comprises or is connected to a template memory including at least a first template electrogram signal and a second template electrogram signal. The evaluation unit compares the recorded IEGM signal with both, the first and the second template electrogram signal and determines at least a first degree of similarity reflecting the similarities between the recorded electrogram signal and the first template electrogram signal, and a second degree of similarity reflecting the similarities between the recorded electrogram signal and the second template electrogram signal. The evaluation unit then calculates a fusion index (FI) from the at least two degrees of similarity.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: June 9, 2015
    Assignee: Biotronik SE & Co. KG
    Inventors: Jie Lian, Dirk Muessig
  • Patent number: 9045491
    Abstract: Disclosed are new thienyl [3,2-d] pyrimidin-4-one compounds shown as the general formula (I), preparation method, pharmaceutical compositions and pharmacological use thereof. The compounds are strong DPPIV (dipeptide peptidase IV) inhibitors and can treat type II diabetes through well inhibiting DPPIV indirectly increasing the content of GLP-1 in vivo and inducing a series of physiological actions in vivo. Therefore, the compounds could be developed as new promising drugs for treating diabetes.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: June 2, 2015
    Assignees: Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Cisen Pharmaceutical Co., Ltd.
    Inventors: Hong Liu, Jia Li, Jian Li, Jingya Li, Jiang Wang, Mingbo Su, Jie Lian, Hualiang Jiang, Kaixian Chen
  • Patent number: 9026198
    Abstract: A method for determining the signal quality of samples in a physiological signal, in particular an electrocardiogram (ECG) signal, is provided. A supra-threshold sample sum, a noise threshold crossing sum, or both are calculated in a noise detection window including the sample to be evaluated, and low signal quality is indicated if either or both of the sums exceed respective values. ECG beat detections can then be labeled as unreliable based on the determination of low signal quality for one or more samples between the detections.
    Type: Grant
    Filed: June 8, 2011
    Date of Patent: May 5, 2015
    Assignee: Biotronik SE & Co. KG
    Inventors: Jie Lian, Dirk Muessig
  • Publication number: 20150080752
    Abstract: A device that monitors and evaluates electrogram signals representing electric activities of a heart chamber, and includes a signal input connected to a mapping catheter, and a signal processing and evaluation unit. The mapping catheter includes one or more electrode poles that pick up electric potentials and generate electrogram signals therefrom.
    Type: Application
    Filed: August 25, 2014
    Publication date: March 19, 2015
    Applicant: BIOTRONIK SE & CO. KG
    Inventors: Jie LIAN, Christopher S. de Voir