Patents by Inventor Jie Lian

Jie Lian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140371811
    Abstract: A spinal cord stimulation device having a stimulation unit for generation and delivery of stimulation pulses, a control unit for controlling the stimulation unit with respect to stimulation intensity and an autonomic nervous system (“ANS”) sensing unit that is configured to generate ANS indicating signals that represent an increased sympathetic tone or an increased parasympathetic tone, respectively. The control unit is configured to control the intensity of respective stimulation pulses depending on a respective ANS indicating signal as generated by said ANS sensing unit.
    Type: Application
    Filed: May 20, 2014
    Publication date: December 18, 2014
    Applicant: BIOTRONIK SE & Co. KG
    Inventors: Jie Lian, Dirk Muessig
  • Publication number: 20140340818
    Abstract: Supercapacitors have composite electrodes that include a porous carbonaceous material such as graphene onto which a metal oxide pseudocapacitor material is deposited in the form of nano-scale particles or a nano-scale film. The composite electrodes exhibit excellent specific capacitance, even at high scan rates.
    Type: Application
    Filed: November 9, 2012
    Publication date: November 20, 2014
    Inventors: Ming Xie, Xiang Sun, Jie Lian, Gongkal Wang
  • Patent number: 8892193
    Abstract: A method for automatic threshold control and detection of lead failure in an implanted medical device obtains three sensing vectors for measurement of an electrocardiogram signal. A dynamic error signal is determined from the vectors, and may be used to set a detection threshold for insufficient ECG signals, and/or to passively monitor the device for indications of lead failure without performing an impedance measurement. Passive mode operation conserves battery power and enables continuous lead integrity checks. A quality factor may also be determined from the error signal, to indicate whether or not signal measurements are valid with respect to noise levels. If the detection threshold is allowed to decay between successive features of the electrocardiogram, the decay rate may be made adaptive such that it automatically adjusts to changes in heart rate or to changes in amplitude of the electrocardiogram features.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: November 18, 2014
    Assignee: Biotronik SE & Co. KG
    Inventors: J. Christopher Moulder, Jie Lian
  • Publication number: 20140323466
    Abstract: Disclosed are new thienyl[3,2-d]pyrimidin-4-one compounds shown as the general formula (I), preparation method, pharmaceutical compositions and pharmacological use thereof. The compounds are strong DPPIV (dipeptide peptidase IV) inhibitors and can treat type II diabetes through well inhibiting DPPIV indirectly increasing the content of GLP-1 in vivo and inducing a series of physiological actions in vivo. Therefore, the compounds could be developed as new promising drugs for treating diabetes.
    Type: Application
    Filed: October 23, 2012
    Publication date: October 30, 2014
    Inventors: Hong Liu, Jia Li, Jian Li, Jingya Li, Jiang Wang, Mingbo Su, Jie Lian, Hualiang Jiang, Kaixian Chen
  • Publication number: 20140316479
    Abstract: An implantable medical device includes an actuator and/or sensor portion to be fixed to bodily tissue by means of a fixation mechanism, to act on the tissue and/or to detect a signal from the tissue, wherein at least one detector element, preferably a plurality of detector elements, adapted for detecting the close proximity of bodily tissue, is arranged on the actuator and/or sensor portion of the device, and an output of the or each detector element being connected or connectable to a detection signal evaluation unit for deriving a fixation state verification from detection signals provided by the or each detector element.
    Type: Application
    Filed: April 3, 2014
    Publication date: October 23, 2014
    Applicant: BIOTRONIK SE & Co. KG
    Inventors: Brian M. Taff, Hannes Kraetschmer, Jie Lian
  • Patent number: 8868181
    Abstract: An implantable cardiac electrostimulator includes an atrial sensing channel generating an atrial sense event signal upon detection of atrial activity, a ventricular sensing channel generating a ventricular sense event signal upon detection of ventricular activity, a VES detector detecting ventricular extrasystoles, atrial and ventricular stimulation pulse generators, and a stimulation control unit. The stimulation control unit determines scheduled delivery times of atrial stimulation pulses (T(A)) and/or ventricular stimulation pulses (T(V)), and triggers delivery if no atrial sense event signal arises before the end of an atrial escape interval (VAI) timing out at T(A), or if no ventricular sense event signal arises before the end of a ventricular escape interval (VEI) timing out at T(V). T(A) and T(V) depend upon detection of a ventricular extrasystole, and proper atrioventricular synchrony is maintained by setting a physiologically adequate A-V-delay between T(A) and T(V).
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: October 21, 2014
    Assignee: Biotronik CRM Patent AG
    Inventors: Volker Lang, Jie Lian, Dirk Müssig
  • Publication number: 20140305537
    Abstract: Conventional fueling station has an intrinsic limitation of congested traffic flow, leading to under utilization of fuel dispensers and causing long waiting lines. This invention discloses a novel structure of a fueling station and the method of improving the traffic flow in the fueling station. The disclosed fueling station comprises a passage for entrance, a passage for exit, at least a sequence of two or more fuel dispensers arranged sequentially between said passage for entrance and said passage for exit, wherein each fuel dispenser has at least one fueling space, and said fueling space is configured to enable a vehicle to move into and out of said fueling space without being hindered by another vehicle at a different fueling space.
    Type: Application
    Filed: April 10, 2013
    Publication date: October 16, 2014
    Inventor: Jie Lian
  • Publication number: 20140309539
    Abstract: An implantable cardiac device is provided. The implantable cardiac device includes a sensing unit adapted to measure an intrathoracic or intracardiac impedance, pressure, and/or accelerometry input stream, which includes a patient's respiratory waveforms. Furthermore, the implantable cardiac device includes a quantizer-unit adapted to sample the input stream with an initial sampling frequency Fs, providing input samples of the input stream. The implantable cardiac device further includes a filter bank 50 suited to perform a streaming Wavelet transformation on the input samples on a sample-by-sample basis, using the initial sampling frequency Fs provided by the quantizer-unit, wherein the streaming Wavelet transformation is adapted to perform a source separation, extracting, and separating the respiratory waveforms of the input stream.
    Type: Application
    Filed: April 10, 2014
    Publication date: October 16, 2014
    Inventors: Christopher S. de Voir, J. Christopher Moulder, Jie Lian, Dirk Muessig
  • Patent number: 8843198
    Abstract: The present disclosure refers to a heart stimulator comprising a stimulation control unit, a stimulation unit, an impedance measurement unit and an impedance evaluation unit. The stimulation control unit is operatively connected to the stimulation unit to control timing of stimulation pulses by said stimulation unit. The impedance measurement unit is configured to determine an impedance signal reflecting intracardiac impedance. The impedance evaluation unit is operatively connected to the impedance measurement unit and to the stimulation control unit and is configured to evaluate the impedance signal so as to determine an isovolumic contraction time, an isovolumic relaxation time, an ejection time and a filling time from said impedance signal. The stimulation control unit is further configured to control timing of stimulation pulses depending on a performance index.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: September 23, 2014
    Assignee: Biotronik SE & Co. KG
    Inventors: Jie Lian, Volker Lang, Hannes Kraetschmer, Dirk Muessig
  • Publication number: 20140207013
    Abstract: A heart monitoring and/or therapy device for detecting and quantifying fusion beats, wherein the device includes an IEGM signal sensing channel that puts out a recorded IEGM signal and an evaluation unit operatively connected to said IEGM signal sensing channel that detects fusion beats. The evaluation unit comprises or is connected to a template memory including at least a first template electrogram signal and a second template electrogram signal. The evaluation unit compares the recorded IEGM signal with both, the first and the second template electrogram signal and determines at least a first degree of similarity reflecting the similarities between the recorded electrogram signal and the first template electrogram signal, and a second degree of similarity reflecting the similarities between the recorded electrogram signal and the second template electrogram signal. The evaluation unit then calculates a fusion index (FI) from the at least two degrees of similarity.
    Type: Application
    Filed: December 3, 2013
    Publication date: July 24, 2014
    Applicant: BIOTRONIK SE & CO. KG
    Inventors: Jie Lian, Dirk Muessig
  • Patent number: 8788026
    Abstract: The type of arrhythmia in a patient's heart can be determined by monitoring the atrial and ventricular rate of the heart; detecting a pathological initial ventricular and/or atrial rate during a first time period; if a pathological initial rate is detected, then administering at least one antiarrhythmic cardioactive drug over a short second time period; detecting the heart's response to the administered drug(s), as by comparing the responsive ventricular and atrial rates with the initial ventricular and atrial rates, respectively, within a third time period; and determining the type of atrial or ventricular arrhythmia from the presence or absence of differences, and the type of differences, between the responsive atrial and ventricular rates compared with the initial atrial and ventricular rates. The invention further involves a related device which includes an implantable cardiac device (10) and a drug delivery device (20).
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: July 22, 2014
    Assignee: Biotronik SE & Co. KG
    Inventors: Jie Lian, Volker Lang
  • Patent number: 8718750
    Abstract: Exemplary methods and apparatuses are disclosed that provide for determination of an atrio-ventricular delay on a beat-to-beat basis by determining a P-wave duration from electric signals corresponding to electric potentials in a heart, and determining the atrio-ventricular delay on a beat-to-beat basis such that the atrio-ventricular delay for an individual heart cycle depends on the P-wave duration of a same or an immediately preceding heart cycle.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: May 6, 2014
    Assignee: BIOTRONIK SE & Co. KG
    Inventors: Jie Lian, J. Christopher Moulder, Dirk Muessig
  • Publication number: 20140088399
    Abstract: A method of enhancing the signal-to-noise ratio (SNR) of measured electrocardiogram (ECG) signals is provided. The method includes the steps of providing at least three cardiac input signals derived from the measured ECG signals S1 and forming a first estimate U1 S2 from each of at least three pairs of input signals. Moreover, the method includes the steps of forming a second estimate U2 S3 from each of at least three input signals; comparing S4 the polarity and the amplitude of a first and second estimate U1, U2 to at least one threshold T; generating S5 a composite signal X, wherein the polarity and the amplitude of the composite signal X depend on the result of the comparison; and using S6 the generated composite signal X to produce an output signal with enhanced signal-to-noise ratio (SNR). Furthermore, a corresponding cardiac device is also provided.
    Type: Application
    Filed: August 22, 2013
    Publication date: March 27, 2014
    Applicant: BIOTRONIK SE & Co. KG
    Inventors: Jie Lian, Garth Garner, Dirk Müssig
  • Patent number: 8419645
    Abstract: An implantable medical device that measures respiration parameters based on transthoracic impedance signals, and converts transthoracic impedance signals into a time series of digital values which is filtered with morphological operators to separate the signal into a respiratory component and a cardiac component. Metrics are generated based on the filtered impedance values such as respiratory rate, I/E ratio, tidal volume and minute ventilation.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: April 16, 2013
    Assignee: Biotronik CRM Patent AG
    Inventors: Jie Lian, Dirk Muessig
  • Publication number: 20130079839
    Abstract: The present disclosure refers to a heart stimulator comprising a stimulation control unit, a stimulation unit, an impedance measurement unit and an impedance evaluation unit. The stimulation control unit is operatively connected to the stimulation unit to control timing of stimulation pulses by said stimulation unit. The impedance measurement unit is configured to determine an impedance signal reflecting intracardiac impedance. The impedance evaluation unit is operatively connected to the impedance measurement unit and to the stimulation control unit and is configured to evaluate the impedance signal so as to determine an isovolumic contraction time, an isovolumic relaxation time, an ejection time and a filling time from said impedance signal. The stimulation control unit is further configured to control timing of stimulation pulses depending on a performance index.
    Type: Application
    Filed: September 5, 2012
    Publication date: March 28, 2013
    Inventors: Jie Lian, Volker Lang, Hannes Kraetschmer, Dirk Muessig
  • Patent number: 8396538
    Abstract: Improving the signal-to-noise ratio of electrocardiogram (ECG) measurements facilitates cardiac beat detection in a human or animal patient. ECG signals measured either on the surface of the skin or subcutaneously from pairs of leads may be combined to calculate a differential signal. The measured signal may also be averaged to produce a second estimate. A point-by-point product of the differential signal and the averaged signal is generated if the sample pair has the same polarity. The product signals feature enhanced signal components and reduced noise components, thus improving the signal-to-noise ratio of the to respective input channels. Product signals are then subjected to peak detection through a conventional auto-sensing approach. Preliminary event detection results from the conditional product signals may then be aggregated, and final sense markers for ECG beat detection may be generated by means of a voting algorithm.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: March 12, 2013
    Assignee: Biotronik CRM Patent AG
    Inventors: Garth Garner, Jie Lian, Dirk Muessig
  • Patent number: 8394029
    Abstract: The invention refers to a monitoring device for monitoring and analyzing physiological signals. The monitoring device comprises a transthoracic impedance measurement unit and an evaluation unit connected to the transthoracic impedance measurement unit. The transthoracic impedance measurement unit is adapted to conduct a transthoracic impedance measurement and to generate a transthoracic impedance signal representing a measured transthoracic impedance at consecutive points in time. The evaluation unit being configured to process the transthoracic impedance signal received from the transthoracic impedance measurement unit and to thus generate a respiration signal and to generate therefrom an evaluation signal reflecting at least a diurnal pattern of the respiration rate.
    Type: Grant
    Filed: June 1, 2009
    Date of Patent: March 12, 2013
    Assignee: Biotronik CRM Patent AG
    Inventors: Jie Lian, Sharon Lefkov, Dirk Muessig, Christopher S. de Voir, Michael V. Orlov
  • Patent number: 8380307
    Abstract: The invention is directed to a heart stimulator for left-ventricular pacing comprising a left ventricular stimulation pulse generator connected or connectable to a single electrode lead for left ventricular stimulation having one or more electrodes for delivery of stimulation pulses to left ventricular myocardial heart tissue, said stimulation pulse generator being adapted to generate and deliver stimulation pulses of switchable polarity. The heart stimulator further comprises a control unit connected to the stimulation pulse generator for controlling the stimulation pulse generator and to trigger generation and delivery of stimulation pulses having a polarity controlled by said control unit, wherein the control unit is adapted to control said left ventricular stimulation pulse generator so as to deliver at least a pair of suprathreshold stimulation pulses of opposite polarity.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: February 19, 2013
    Assignee: Biotronik CRM Patent AG
    Inventors: Jie Lian, Garth Garner, Dirk Muessig, Volker Lang
  • Publication number: 20120302904
    Abstract: Exemplary methods and apparatuses are disclosed that provide for determination of an atrio-ventricular delay on a beat-to-beat basis by determining a P-wave duration from electric signals corresponding to electric potentials in a heart, and determining the atrio-ventricular delay on a beat-to-beat basis such that the atrio-ventricular delay for an individual heart cycle depends on the P-wave duration of a same or an immediately preceding heart cycle.
    Type: Application
    Filed: May 2, 2012
    Publication date: November 29, 2012
    Inventors: Jie Lian, J. Christopher Moulder, Dirk Muessig
  • Patent number: 8315694
    Abstract: Heart monitor for detecting ectopic beats in an input electrocardiogram signal that includes an electrocardiogram signal input and a morphological signal analyzer connected to the electrocardiogram signal input, the analyzer being adapted to generate a first time series of values representing the input electrocardiogram signal, a second signal analyzer adapted to generate generating a modified time series of values representing a trend of values of the first time series and a comparison stage being adapted to compare the first time series with the modified time series to thus detect ectopic beats.
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: November 20, 2012
    Assignee: Biotronik CRM Patent AG
    Inventors: Jie Lian, Dirk Muessig