Patents by Inventor Jinbo Lee

Jinbo Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150045319
    Abstract: This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease) and traumatic CNS injury, as well as pain.
    Type: Application
    Filed: July 3, 2014
    Publication date: February 12, 2015
    Inventors: Philip G. Haydon, Jinbo Lee, Jinghui Dong, Stephen Moss, Raquel Revilla-Sanchez
  • Publication number: 20140371167
    Abstract: This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and methods of using those nucleoside derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma and inflammatory conditions.
    Type: Application
    Filed: March 13, 2014
    Publication date: December 18, 2014
    Applicant: TUFTS UNIVERSITY
    Inventors: Philip G. Haydon, Jinbo Lee
  • Patent number: 8785620
    Abstract: This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g. neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease) and traumatic CNS injury, as well as pain.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: July 22, 2014
    Assignee: Tufts University
    Inventors: Philip Haydon, Jinbo Lee
  • Publication number: 20140162972
    Abstract: This disclosure relates to prodrugs of uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of using those prodrugs or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma, and inflammatory conditions.
    Type: Application
    Filed: September 27, 2013
    Publication date: June 12, 2014
    Applicant: Tufts University
    Inventors: Philip G. Haydon, Jinbo Lee
  • Publication number: 20140066613
    Abstract: This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease) and traumatic CNS injury, as well as pain.
    Type: Application
    Filed: November 6, 2013
    Publication date: March 6, 2014
    Applicant: TUFTS UNIVERSITY
    Inventors: Philip Haydon, Jinbo Lee
  • Patent number: 8598141
    Abstract: This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease) and traumatic CNS injury, as well as pain.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: December 3, 2013
    Assignee: Tufts University
    Inventors: Philip Haydon, Jinbo Lee, Jinghui Dong, Stephen Moss, Raquel Revilla-Sanchez
  • Publication number: 20130252919
    Abstract: This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease) and traumatic CNS injury, as well as pain.
    Type: Application
    Filed: March 8, 2013
    Publication date: September 26, 2013
    Applicant: TUFTS UNIVERSITY
    Inventors: Philip Haydon, Jinbo Lee, Jinghui Dong, Stephen Moss, Raquel Revilla-Sanchez
  • Patent number: 8338565
    Abstract: Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: December 25, 2012
    Assignee: Ensemble Therapeutics Corporation
    Inventors: Jinbo Lee, Julian F. Bond, Nicholas Terrett, Frank G. Favaloro, Jr., Daniel Wang, Timothy F. Briggs, Benjamin Adam Seigal, Wei-Chuan Sun, Stephen P. Hale
  • Publication number: 20110263532
    Abstract: The present invention provides novel analogs and derivatives of halofuginone. The invention also provides pharmaceutical and cosmetic compositions thereof and methods for using halofuginone analogs in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, viral infections, ischemic damage, transplant and implant rejection, neurodegenerative diseases, and cosmetic applications.
    Type: Application
    Filed: August 11, 2009
    Publication date: October 27, 2011
    Applicant: President and Fellows of Harvard College
    Inventors: Tracy Keller, Ralph Mazitschek, Malcolm Whitman, Jinbo Lee
  • Publication number: 20100152099
    Abstract: The invention provides macrocyclic compounds and methods for their synthesis and use. In particular, the invention provides macrocyclic compounds that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
    Type: Application
    Filed: August 20, 2009
    Publication date: June 17, 2010
    Inventors: Jinbo Lee, Julian F. Bond, Nicholas Terrett, Frank G. Favaloro, JR., Daniel Wang, Timothy F. Briggs, Benjamin A. Seigal, Wei-Chuan Sun, Stephen P. Hale
  • Patent number: 7674822
    Abstract: This invention relates to modulating (e.g., inhibiting) protein tyrosine phosphatase 1B (PTP1B).
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: March 9, 2010
    Assignee: Wyeth
    Inventors: Jinbo Lee, Michael J. Smith, Alessandro Fabio Moretto, Zhao-Kui Wan, Eva Deanna Binnun, Weixin Xu, Kenneth W. Foreman, Diane M. Joseph-McCarthy, David V. Erbe, Steve Y. Tam
  • Publication number: 20100029648
    Abstract: This invention relates to inhibiting 11?HSD1.
    Type: Application
    Filed: August 11, 2009
    Publication date: February 4, 2010
    Inventors: Jason Shaoyun Xiang, Eddine Saiah, Steve Y. Tam, John C. McKew, Lihren Chen, Manus Ipek, Katherine Lee, Huan-Qiu Li, Jianchang Li, Wei Li, Tarek Suhayl Mansour, Vipin Suri, Richard Vargas, Yuchuan Wu, Zhao-Kui Wan, Jinbo Lee, Eva Binnun, Douglas P. Wilson
  • Patent number: 7632838
    Abstract: This invention relates to inhibiting 11?HSD1.
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: December 15, 2009
    Assignee: Wyeth
    Inventors: Jason Shaoyun Xiang, Eddine Saiah, Steve Y. Tam, John C. Mckew, Lihren Chen, Manus Ipek, Huan-Qiu Li, Jianchang Li, Wei Li, Tarek Suhayl Mansour, Vipin Suri, Yuchuan Wu, Zhao-Kui Wan, Jinbo Lee, Eva Binnun, Douglas P. Wilson
  • Patent number: 7521473
    Abstract: Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: April 21, 2009
    Assignee: Wyeth
    Inventors: Jinbo Lee, Zhao-Kui Wan, Douglas P. Wilson, Bruce C. Follows, Steven J. Kirincich, Michael J. Smith, Jun-Jun Wu, Kenneth W. Foreman, David V. Erbe, Yan-Ling Zhang, Weixin Xu, Steve Y. Tam
  • Publication number: 20090048286
    Abstract: Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.
    Type: Application
    Filed: September 23, 2008
    Publication date: February 19, 2009
    Applicant: Wyeth
    Inventors: Jinbo Lee, Steven J. Kirincich, Michael J. Smith, Douglas P. Wilson, Bruce C. Follows, Zhao-Kui Wan, Diane M. Joseph-McCarthy, David V. Erbe, Yan-Ling Zhang, Weixin Xu, Steve Y. Tam
  • Publication number: 20080004325
    Abstract: This invention relates to modulating (e.g., inhibiting) protein tyrosine phosphatase 1b (PTP1b).
    Type: Application
    Filed: June 29, 2007
    Publication date: January 3, 2008
    Applicant: Wyeth
    Inventors: Jinbo Lee, Zhao-Kui Wan, Douglas P. Wilson, Eva Binnun, David V. Erbe, Eddine Saiah
  • Publication number: 20070219198
    Abstract: This invention relates to inhibiting 11?HSD1.
    Type: Application
    Filed: February 7, 2007
    Publication date: September 20, 2007
    Applicant: Wyeth
    Inventors: Jason Xiang, Eddine Saiah, Steve Tam, John Mckew, Lihren Chen, Manus Ipek, Katherine Lee, Huan-Qiu Li, Jianchang Li, Wei Li, Tarek Mansour, Vipin Suri, Richard Vargas, Yuchuan Wu, Zhao-Kui Wan, Jinbo Lee, Eva Binnun, Douglas Wilson
  • Publication number: 20060135488
    Abstract: This invention relates to modulating (e.g., inhibiting) protein tyrosine phosphatase 1B (PTP1B).
    Type: Application
    Filed: November 22, 2005
    Publication date: June 22, 2006
    Inventors: Jinbo Lee, Michael Smith, Alessandro Moretto, Zhao-Kui Wan, Eva Binnun, Weixin Xu, Kenneth Foreman, Diane Joseph-McCarthy, David Erbe, Steve Tam
  • Publication number: 20050203081
    Abstract: Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.
    Type: Application
    Filed: February 23, 2005
    Publication date: September 15, 2005
    Inventors: Jinbo Lee, Steve Kirincich, Michael Smith, Douglas Wilson, Bruce Follows, Zhao-Kui Wan, Diane Joseph-McCarthy, David Erbe, Yan-Ling Zhang, Weixin Xu, Steve Tam
  • Publication number: 20050203087
    Abstract: Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted thiophene compounds such as, for example, 2-carboxyl, 3-carboxymethoxy, 5-aryl substituted thiophenes, can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.
    Type: Application
    Filed: February 23, 2005
    Publication date: September 15, 2005
    Inventors: Jinbo Lee, Zhao-Kui Wan, Douglas Wilson, Bruce Follows, Steven Kirincich, Michael Smith, Jun-Jun Wu, Kenneth Foreman, David Erbe, Yan-Ling Zhang, Weixin Xu, Steve Tam