Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: A modal information completion method, an apparatus, and a device are provided. A completion apparatus first obtains a modal information group, wherein the modal information group includes at least two pieces of modal information. Then, the completion apparatus may determine, based on an attribute of the modal information group, whether a part or all of first modal information in the modal information group is missing. Subsequently, the completion apparatus determines a target feature vector of the first modal information based on a preset feature vector mapping relationship and a feature vector of second modal information in the modal information group, so that accuracy of the target feature vector of the first modal information is ensured.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: A sprocket system including a sprocket assembled from multiple disc sprockets coaxially aligned and secured together to provide a desired axial width for the sprocket is described. In some embodiments, the sprocket described herein is a hub-less sprocket.

Abstract: A resonant converter having a pre-conduction mechanism for realizing a wide output voltage range is provided. The resonant converter includes a first circuit and a second circuit. The first circuit includes a plurality of primary-side switches. The plurality of primary-side switches includes a first high-side switch, a second high-side switch, a first low-side switch and a second low-side switch. The second circuit includes a plurality of secondary-side switches. The plurality of secondary-side switches includes a third high-side switch, a fourth high-side switch, a third low-side switch and a fourth low-side switch. When the second low-side switch and the first low-side switch are turned on and a current time reaches a preset on time, the fourth high-side switch and the third low-side switch are turned on.

Abstract: Disclosed is a use of a liposomal pharmaceutical preparation of mitoxantrone in the preparation of a medicament for treating lymphoma, wherein the lymphoma is preferably non-Hodgkin's lymphoma, further preferably aggressive non-Hodgkin's lymphoma, more preferably diffuse large B-cell lymphoma or peripheral T-cell lymphoma, and more further preferably relapsed or refractory diffuse large B-cell lymphoma or peripheral T-cell lymphoma. The mitoxantrone liposomes are used as single anti-tumor therapeutic agent without being combined with other anti-tumor agents.

Abstract: A display panel and a display device are provided, and the display panel includes a bonding area, a thin film transistor functional layer, and a conductive structure layer disposed in order. A part of the thin film transistor functional layer disposed on the bonding area includes a first inorganic layer and a plurality of signal lines. The conductive structure layer includes a second inorganic layer and a conductive layer disposed in order, and a part of the second inorganic layer disposed in the bonding area is disposed on the signal line and is directly disposed on the first inorganic layer.

Abstract: An interleaved three-phase Y-Delta connected power converter is provided. The interleaved three-phase Y-Delta connected power converter includes an input voltage source, an input capacitor, a first converter module, a second converter module, an output circuit, and a control circuit. The control circuit calculates a phase shift amount and an operating frequency through voltage and current feedbacks to generate a plurality of switch signal groups for controlling the first converter module and the second converter module, respectively.

Abstract: Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by ROR?. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.

Abstract: Provided herein are compounds of formula I: wherein the variables are defined herein, processes of making them, and methods of treating cancer comprising administering such compounds.

Abstract: A sample three-dimensional image is acquired. The sample three-dimensional image is labeled with actual location information of an actual region of a three-dimensional target. One or more pieces of prediction region information corresponding to one or more sub-images of the sample three-dimensional image are acquired by performing target detection on the sample three-dimensional image using the three-dimensional target detection model. Each piece of the prediction region information includes prediction confidence and prediction location information of a prediction region. A loss value of the three-dimensional target detection model is determined using the actual location information and the one or more pieces of the prediction region information. A parameter of the three-dimensional target detection model is adjusted using the loss value.

Abstract: A digital pre-distortion method for a multiband signal, an electronic device and a non-transitory computer-readable storage medium are disclosed. The digital pre-distortion method may include: determining a possible power amplifier distortion according to configuration of a signal issued by a cell; selecting a basis function of pre-distortion according to the possible power amplifier distortion; solving, according to a pre-collected reference multiband signal and a corresponding feedback signal, the selected basis function to obtain a pre-distortion parameter; and processing an input multiband signal according to the selected basis function and the pre-distortion parameter to generate a pre-distortion signal.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: The present invention provides a compound having a structure of formula (I), a preparation method and use thereof, and a pharmaceutical composition containing the compound, wherein R is methyl, ethyl, propyl, vinyl or propenyl. The present invention also provides a crystalline form of the compound, a preparation method and use of the crystalline form, and a pharmaceutical composition comprising the crystalline form. The compounds having the structure of formula (I) of the present invention are present in a solid form, which not only can solve the problem of clopidogrel resistance, but also can solve the problem of severe hemorrhagic side effect and poor safety of some drugs, as well as the problem of poor stability of existing compounds. It can be developed into an ADP receptor antagonist antiplatelet agent with clear therapeutic effect, no resistance and better stability.

Abstract: A question answering method based on a knowledge graph are disclosed, including: After obtaining a first natural query statement including a first query entity and first entity characteristic information, the terminal queries the knowledge graph based on the first query entity and the first entity characteristic information, to obtain a first result. The terminal obtains a second natural query statement after outputting the first result. The terminal determines a missing part in the second natural query statement based on the first query entity or the first entity characteristic information. The terminal queries the knowledge graph based on the missing part in the second natural query statement to obtain a second result, and outputs the second result.

Abstract: An LLC resonant converter is provided, which includes an input power source, a full-bridge switch circuit, a resonant circuit, a transformer, a rectifier circuit, a load, and a control circuit. The control circuit includes a load detection circuit and a valley switching circuit. The load detection circuit detects a load state of the load. The valley switching circuit is configured to, in response to the load state being a light load state: correspondingly generate a first difference voltage; calculate a first switch on-time for a first switch and a fourth switch; generate switching signals that control the first switch and the fourth switch to be turned off, and detect voltage valleys of a second switch and a third switch; and generate the switching signals to control the second switch and the third switch to be turned on according to the calculated first switch on-time.

Abstract: Provided are an image processing method and apparatus, and a computer storage medium. The method includes that: first segmentation is performed on a to-be-processed image to determine at least one target image region in the to-be-processed image; second segmentation is performed on the at least one target image region to determine first segmentation results of a target in the at least one target image region; and fusion and segmentation are performed on the first segmentation results and the to-be-processed image to determine a second segmentation result of the target in the to-be-processed image.

Abstract: A MEMS device is provided. The MEMS device includes a substrate having at least one contact, a first dielectric layer disposed on the substrate, at least one metal layer disposed on the first dielectric layer, a second dielectric layer disposed on the first dielectric layer and the metal layer and having a recess structure, and a structure layer disposed on the second dielectric layer and having an opening. The opening is disposed to correspond to the recess structure, and the cross-sectional area at the bottom of the opening is smaller than the cross-sectional area at the top of the recess structure. The MEMS device also includes a packaging layer, and at least a portion of the packaging layer is disposed in the opening and the recess structure. The second dielectric layer, the structure layer, and the packaging layer define a chamber.

Abstract: An image processing method includes: performing first segmentation processing on an image to be processed, and determining a segmentation region of a target in said image (S11); determining, according to the position of the center point of the segmentation region of the target, an image region where the target is located (S12); and performing second segmentation processing on the image region where each target is located, and determining the segmentation result of the target in said image (S13).

Abstract: An LLC resonant converter is provided, which includes an input power source, a full-bridge switch circuit, a resonant circuit, a transformer, a rectifier circuit, a load, and a control circuit. The control circuit includes a load detection circuit and a valley switching circuit. The load detection circuit detects a load state of the load. The valley switching circuit is configured to, in response to the load state being a light load state: correspondingly generate a first difference voltage; calculate a first switch on-time for a first switch and a fourth switch; generate switching signals that control the first switch and the fourth switch to be turned off, and detect voltage valleys of a second switch and a third switch; and generate the switching signals to control the second switch and the third switch to be turned on according to the calculated first switch on-time.