Patents by Inventor Jingpeng Fu

Jingpeng Fu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220135631
    Abstract: The disclosure of the present application relates to a secretory deleted split hand/split foot 1 (sDSS1) protein, the amino acid sequence thereof, the nucleic acid sequence thereof, and the applications of the same. The sDSS1 protein is a secretory protein from higher primate, and can be detected in human serum and cerebral spinal fluid (CSF). The sDSS1 protein can form conjugate with oxidized protein under nonenzymatic condition or with amyloid-beta (A?) polypeptide to reduce formation of A? oligomer. The addition of sDSS1 protein to culture medium can shield the cytotoxicity induced by oxidized protein, A? oligomer, amylin oligomer and glycosylated protein, so as to protect the cells against these toxoproteins. The sDSS1 protein can prolong survival time of senescence-accelerated mice significantly.
    Type: Application
    Filed: November 8, 2021
    Publication date: May 5, 2022
    Inventors: Yinghao Zhang, Jingpeng Fu, Jia Wan
  • Publication number: 20220040257
    Abstract: A method for preventing or treating atherosclerosis or atherosclerosis-related diseases in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of sDSS1 protein or a fragment or variant thereof, a nucleic acid encoding the sDSS1 protein or a fragment or variant thereof or a vector containing the nucleic acid, transplanting into the individual with a cell expressing the sDSS1 protein or a fragment or variant thereof, or tissues or organs containing the sDSS1 protein or a fragment or variant thereof or the nucleic acid, and/or infusing into the individual serum or interstitial fluid containing the sDSS1 protein or a fragment or variant thereof or the nucleic acid.
    Type: Application
    Filed: March 10, 2021
    Publication date: February 10, 2022
    Inventors: Yinghao Zhang, Guirui Yan, Yao Wang, Jingpeng Fu
  • Patent number: 11198712
    Abstract: The disclosure of the present application relates to a secretory deleted split hand/split foot 1 (sDSS1) protein, the amino acid sequence thereof, the nucleic acid sequence thereof, and the applications of the same. The sDSS1 protein is a secretory protein from higher primate, and can be detected in human serum and cerebral spinal fluid (CSF). The sDSS1 protein can form conjugate with oxidized protein under nonenzymatic condition or with amyloid-beta (A?) polypeptide to reduce formation of A? oligomer. The addition of sDSS1 protein to culture medium can shield the cytotoxicity induced by oxidized protein, A? oligomer, amylin oligomer and glycosylated protein, so as to protect the cells against these toxoproteins. The sDSS1 protein can prolong survival time of senescence-accelerated mice significantly.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: December 14, 2021
    Assignee: Shanghai Clear Fluid Biomedical Science Co., Ltd.
    Inventors: Yinghao Zhang, Jingpeng Fu, Jia Wan
  • Publication number: 20210009644
    Abstract: The disclosure of the present application relates to a secretory deleted split hand/split foot 1 (sDSS1) protein, the amino acid sequence thereof, the nucleic acid sequence thereof, and the applications of the same. The sDSS1 protein is a secretory protein from higher primate, and can be detected in human serum and cerebral spinal fluid (CSF). The sDSS1 protein can form conjugate with oxidized protein under nonenzymatic condition or with amyloid-beta (A?) polypeptide to reduce formation of A? oligomer. The addition of sDSS1 protein to culture medium can shield the cytotoxicity induced by oxidized protein, A? oligomer, amylin oligomer and glycosylated protein, so as to protect the cells against these toxoproteins. The sDSS1 protein can prolong survival time of senescence-accelerated mice significantly.
    Type: Application
    Filed: September 22, 2020
    Publication date: January 14, 2021
    Inventors: Yinghao Zhang, Jingpeng Fu, Jia Wan
  • Patent number: 10815282
    Abstract: The disclosure of the present application relates to a secretory deleted split hand/split foot 1 (sDSS1) protein, the amino acid sequence thereof, the nucleic acid sequence thereof, and the applications of the same. The sDSS1 protein is a secretory protein from higher primate, and can be detected in human serum and cerebral spinal fluid (CSF). The sDSS1 protein can form conjugate with oxidized protein under nonenzymatic condition or with amyloid-beta (A?) polypeptide to reduce formation of A? oligomer. The addition of sDSS1 protein to culture medium can shield the cytotoxicity induced by oxidized protein, A? oligomer, amylin oligomer and glycosylated protein, so as to protect the cells against these toxoproteins. The sDSS1 protein can prolong survival time of senescence-accelerated mice significantly.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: October 27, 2020
    Assignee: Shanghai Clear Fluid Biomedical Science Co., Ltd.
    Inventors: Yinghao Zhang, Jingpeng Fu, Jia Wan
  • Publication number: 20190085041
    Abstract: The present application discloses a secretory protein, including polypeptide sequence, nucleic acid sequence, operating principle and application area of sDSS1 protein. The sDSS1 protein is a secretory protein of higher primate, and can be detected in human serum and CSF. The sDSS1 protein can be combined with oxidation protein under nonenzymatic condition to form polymer or with A? polypeptide to reduce formation of A? oligomer. The addition of sDSS1 protein to culture medium can shield the cytotoxicity induced by oxidation protein, A? oligomer, amylin oligomer and glycosylated protein, so as to protect the cells against these toxoproteins. The sDSS1 protein can prolong survival time of senescence-accelerated mice significantly.
    Type: Application
    Filed: September 28, 2018
    Publication date: March 21, 2019
    Inventors: Yinghao Zhang, Jingpeng Fu, Jia Wan