Patents by Inventor Jinhua J. Song
Jinhua J. Song has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9199904Abstract: The present invention relates to a process of making a compound of formula (XII) or (XIIA): wherein R1,R2, R4 and X are as defined herein.Type: GrantFiled: March 15, 2012Date of Patent: December 1, 2015Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Jean-Nicolas Desrosiers, Joe Ju Gao, Jason Alan Mulder, Jinhua J. Song, Xingzhong Zeng
-
Publication number: 20150038731Abstract: The present invention relates to a process of making a compound of formula (XII) or (XIIA): wherein R1, R2, R4 and X are as defined herein.Type: ApplicationFiled: March 15, 2012Publication date: February 5, 2015Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Jean-Nicolas Desrosiers, Joe Ju Gao, Jason Alan Mulder, Jinhua J. Song, Xingzhong Zeng
-
Publication number: 20140135493Abstract: Disclosed is a process for making diastereomeric compound of the formula (I): wherein m, n and R1 to R4 are as defined herein. The process of the invention provides the compound of formula (I) in high yield and substantially free of the corresponding diastereomers. The compounds of formula (I) prepared by the process of the invention are useful for making pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors.Type: ApplicationFiled: December 15, 2011Publication date: May 15, 2014Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Daniel Robert Fandrick, Zhi-Hui Lu, Diana Crimhilda Reeves, Jonathan Timothy Reeves, Chris Hugh Senanayake, Jinhua J. Song, Yongda Zhang
-
Publication number: 20120136158Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are intermediates thereof, and methods of making and methods of using same.Type: ApplicationFiled: February 8, 2012Publication date: May 31, 2012Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Brian Nicholas COOK, Darren DiSALVO, Daniel Robert FANDRICK, Christian HARCKEN, Daniel KUZMICH, Thomas Wai-Ho LEE, Pingrong LIU, John LORD, Can MAO, Jochen NEU, Brian Christopher RAUDENBUSH, Hossein RAZAVI, Jonathan Timothy REEVES, Jinhua J. SONG, Alan David SWINAMER, Zhulin TAN
-
Publication number: 20120035370Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are intermediates thereof, and methods of making and methods of using same.Type: ApplicationFiled: October 14, 2011Publication date: February 9, 2012Applicant: Boehringer Ingelheim International GmbHInventors: Brian Nicholas COOK, Darren DiSALVO, Daniel Robert FANDRICK, Christian HARCKEN, Daniel KUZMICH, Thomas Wai-Ho LEE, Pingrong LIU, John LORD, Can MAO, Jochen NEU, Brian Christopher RAUDENBUSH, Hossein RAZAVI, Jonathan Timothy REEVES, Jinhua J. SONG, Alan David SWINAMER, Zhulin TAN
-
Publication number: 20110130567Abstract: A process for stereoselective synthesis of a compound of Formula (X) wherein: R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl, wherein each substituent group of R1 is optionally independently substituted with one to three substituents selected from C1-C3 alkyl, C1-C3 alkoxy, phenyl, and alkoxyphenyl; R2 and R3 are each independently C1-C5 alkyl; R4 is C1-C5 alkyl optionally independently substituted with one to three substituent groups, wherein each substituent group of R4 is independently C1-C3 alkyl, hydroxy, halogen, amino, or oxo; and R5 is a heteroaryl group substituted with one to three substituent groups, wherein each substituent group of R5 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfonylamino, aminosulfonyl, C1-C5 alkylaminosulfonyl, C1-C5 dialkyType: ApplicationFiled: May 27, 2010Publication date: June 2, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: DANIEL R. FANDRICK, JONATHAN T. REEVES, JINHUA J. SONG, ZHULIN TAN, BO QU, NATHAN K. YEE, SONIA RODRIGUEZ
-
Publication number: 20110130591Abstract: A process for synthesis of a compound of Formula (X) wherein: R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl, wherein each substituent group of R1 is optionally independently substituted with one to three substituents selected from C1-C3 alkyl, C1-C3 alkoxy, phenyl, and alkoxyphenyl; and R2 and R3 are each independently C1-C5 alkyl.Type: ApplicationFiled: May 27, 2010Publication date: June 2, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Daniel R. FANDRICK, Jonathan T. REEVES, Jinhua J. SONG
-
Publication number: 20110130578Abstract: A process for stereoselective synthesis of a compound of Formula (X) or Formula (X?) wherein: R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C1-C5 alkoxy, C1-C5 alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, C1-C5 alkoxycarbonylamino, aminosulfonyl, C1-C5 alkylaminosulfonyl, C1-C5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, nitro, or C1-C5 alkylthio wherein the sulfur atom is oxidized to sulfoxide or sulfone, and R2 and R3 are each independently hydrogen or C1-C5 alkyl.Type: ApplicationFiled: May 27, 2010Publication date: June 2, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Daniel R. FANDRICK, Daniel KUZMICH, Jonathan T. REEVES, Jinhua J. SONG, Zhulin TAN, Thomas LEE
-
Patent number: 7884246Abstract: Disclosed is a process for preparing substituted anisidines of formula I starting from substituted cyclic hydroxy-ketones II via aromatization through a substituted oxime intermediate IV in which R is C1-C6 alkyl or halogen, and Alk is C1-C6 alkyl. The substituted anisidines of formula I have been found to be useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections.Type: GrantFiled: November 1, 2006Date of Patent: February 8, 2011Assignee: Boehringer Ingelheim International GmbHInventors: Fabrice Gallou, Heewon Lee, Chris Hugh Senanayake, Jinhua J. Song, Zhulin Tan, Jinghua Xu, Nathan K. Yee
-
Patent number: 7879873Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.Type: GrantFiled: September 22, 2009Date of Patent: February 1, 2011Assignee: Boehringer Ingelheim International GmbHInventors: Brian Nicholas Cook, Darren DiSalvo, Daniel Robert Fandrick, Christian Harcken, Daniel Kuzmich, Thomas Wai-Ho Lee, Pingrong Liu, John Lord, Can Mao, Jochen Neu, Brian Christopher Raudenbush, Hossein Razavi, Jonathan Timothy Reeves, Jinhua J. Song, Alan David Swinamer, Zhulin Tan
-
Publication number: 20100312013Abstract: A process for synthesis of a compound of Formula (X) wherein: R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl, wherein each substituent group of R1 is optionally independently substituted with one to three substituents selected from C1-C3 alkyl, C1-C3 alkoxy, phenyl, and alkoxyphenyl; and R2 and R3 are each independently C1-C5 alkyl.Type: ApplicationFiled: May 27, 2010Publication date: December 9, 2010Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Daniel R. FANDRICK, Nathan K. YEE, Jinhua J. SONG, Jonathan T. REEVES
-
Publication number: 20100093724Abstract: Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.Type: ApplicationFiled: September 22, 2009Publication date: April 15, 2010Applicant: Boehringer Ingelheim International GmbHInventors: Brian Nicholas COOK, Darren DiSALVO, Daniel Robert FANDRICK, Christian HARCKEN, Daniel KUZMICH, Thomas Wai-Ho LEE, Pingrong LIU, John LORD, Can MAO, Jochen NEU, Brian Christopher RAUDENBUSH, Hossein RAZAVI, Jonathan Timothy REEVES, Jinhua J. SONG, Alan David SWINAMER, Zhulin TAN
-
Patent number: 7642381Abstract: The process of the present invention can be briefly summarized as depicted in the following scheme: R1 is C1-Calkyl, R2 is C1-C6alkyl and Hal is a halogen atom.Type: GrantFiled: January 18, 2007Date of Patent: January 5, 2010Assignee: Boehringer Ingelheim International GmbHInventors: Jinhua J. Song, Jinghua Xu
-
Patent number: 7507843Abstract: A process for stereoselective synthesis of compounds of Formula X wherein: R1 is an aryl or heteroaryl group, each optionally independently substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl, C1-C5 alkoxy, C2-C5 alkenyloxy, C2-C5 alkynyloxy, aryloxy, C1-C5 alkanoyloxy, C1-C5 alkanoyl, aroyl, trifluoromethyl, trifluoromethoxy, or C1-C5 alkylthio, wherein each substituent group of R1 is optionally independently substituted with one to three substituent groups selected from methyl, methoxy, fluoro, chloro, hydroxy, oxo, cyano, or amino; and R2 and R3 are each independently hydrogen or C1-C5 alkyl, or R2 and R3 together with the carbon atom they are commonly attached to form a C3-C8 spiro cycloalkyl ring.Type: GrantFiled: September 30, 2004Date of Patent: March 24, 2009Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Jinhua J. Song, Zhulin Tan, Jinghua Xu, Nathan K. Yee, Chris H. Senanayake
-
Publication number: 20080312473Abstract: The process of the present invention can be briefly summarized as depicted in the following scheme: R1 is C1-Calkyl, R2 is C1-C6alkyl and Hal is a halogen atom.Type: ApplicationFiled: January 18, 2007Publication date: December 18, 2008Inventors: Jinhua J. Song, Jinghua Xu
-
Publication number: 20080293972Abstract: Disclosed is a process for preparing substituted anisidines of formula I starting from substituted cyclic hydroxy-ketones II via aromatization through a substituted oxime intermediate IV in which R is C1-C6 alkyl or halogen, and Alk is C1-C6 alkyl. The substituted anisidines of formula I have been found to be useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections.Type: ApplicationFiled: November 1, 2006Publication date: November 27, 2008Inventors: Fabrice Gallou, Heewon Lee, Chris Hugh Senanayake, Jinhua J. Song, Zhulin Tan, Jinghua Xu, Nathan K. Yee
-
Patent number: 7425629Abstract: A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.Type: GrantFiled: October 2, 2006Date of Patent: September 16, 2008Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Jinhua J. Song, Jonathan T. Reeves, Frank Roschangar, Zhulin Tan, Nathan K. Yee
-
Patent number: 7179919Abstract: A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.Type: GrantFiled: March 2, 2005Date of Patent: February 20, 2007Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Jinhua J. Song, Zhulin Tan, Nathan K. Yee, Chris Hugh Senanayake, Jinghua Xu, Fabrice Gallou
-
Patent number: 7022883Abstract: Disclosed are methods of making aryl intermediate compounds of the formula (A) which are useful in the production of heteroaryl ureas, Y and P are defined herein below.Type: GrantFiled: November 17, 2003Date of Patent: April 4, 2006Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Jinhua J. Song, Zhulin Tan, Nathan K. Yee
-
Patent number: 6916924Abstract: This invention relates to novel processes for preparing heteroaryl-substituted urea compounds of formula (I): which are useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. X, Ar, L, Q and are described herein.Type: GrantFiled: February 12, 2002Date of Patent: July 12, 2005Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Zhulin Tan, Jinhua J. Song