Patents by Inventor Jiro Tsuji

Jiro Tsuji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5600047
    Abstract: A process for producing an optically active olefin represented by a formula ##STR1## wherein R.sup.1 represents an organic group and X represents a polycyclic carbon ring group, by reacting a corresponding optically active ester derivative represented by a formula ##STR2## wherein R.sup.1 and X are as defined above and R represents a hydrogen atom, an alkoxy group, an alkenyloxy group or a substituted or unsubstituted aralkyloxy group, with formic acid or a salt thereof in the presence of a catalyst comprising a palladium salt and a tertiary phosphine.Said process makes it possible to produce, at a high yield at a high selectivity, an optically active olefin which has a physiological activity and is useful as a medicine or is useful as an intermediate for the synthesis of physiologically active steroids. Further, said process uses no harmful reagent such as mercury or the like. Thus, it is advantageous as an industrial process.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: February 4, 1997
    Assignee: Kuraray Co., Ltd.
    Inventors: Tadakatsu Mandai, Jiro Tsuji, Manzo Shiono
  • Patent number: 5359055
    Abstract: There are provided pregnane derivatives represented by formula ##STR1## wherein A.sup.1 represents a hydrogen atom or a hydroxyl group, A.sup.2 represents a substituent such as a hydroxyl group when A.sup.1 represents a hydrogen atom, or A.sup.2 represents a hydrogen atom when A.sup.1 represents a hydroxyl group, or A.sup.1 and A.sup.2 are combined together to form an oxo group; D.sup.1 represents a substituent such as a hydroxyl group, and D.sup.2 represents a hydrogen atom, or D.sup.1 and D.sup.2 are combined together to form an epoxy group or a single bond; D.sup.3, D.sup.5 and D.sup.7 each represents a hydrogen atom, D.sup.4 represents a hydroxyl group, and D.sup.6 represents a substituent such as a hydroxyl group, or D.sup.3 and D.sup.4 may be combined together to form an epoxy group or a single bond, or D.sup.4 and D.sup.5 may be combined together to form a single bond, or D.sup.5 and D.sup.6 may be combined together to form an epoxy group or a single bond, or D.sup.6 and D.sup.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: October 25, 1994
    Assignee: Kuraray Co., Ltd.
    Inventors: Jiro Tsuji, Takashi Takahashi, Masao Tsuji, Naoshi Nakagawa, Tetsuo Takigawa
  • Patent number: 5322939
    Abstract: A process for preparing an azetidin-2-one derivative represented by formula (2): ##STR1## wherein R.sup.4 and R.sup.5, which may be the same or different, each represents a hydrogen atom, an alkyl group having from 1 to 8 carbon atoms, or an alkyl group having from 1 to 8 carbon atoms substituted with an alkoxy group, an acyl group, or an alkoxycarbonyl group; R.sup.6 represents a protective group for an amino group; and R.sup.7 represents a vinylidene group of formula ##STR2## or an acetylene group of formula ##STR3## wherein R.sup.2 and R.sup.3, which may be the same or different, each represents a hydrogen atom or an alkyl group having from 1 to 8 carbon atoms; and R.sup.8 represents an alkyl group having from 1 to 8 carbon atoms corresponding to R.sup.2 or R.sup.3, which comprises reacting a propargyl alcohol derivative represented by formula (1): ##STR4## wherein R.sup.1 represents an alkyl group having from 1 to 6 carbon atoms, a phenyl group, or a halogen-substituted phenyl group; R.sup.2, R.sup.3, R.
    Type: Grant
    Filed: July 7, 1992
    Date of Patent: June 21, 1994
    Assignee: Takasago International Corporation
    Inventors: Tadakatsu Mandai, Jiro Tsuji
  • Patent number: 5218109
    Abstract: Steroid compounds of the following general formulas (I), (II) and (III) are provided: ##STR1## In the above formulas, R.sup.1 and R.sup.2 each is a hydrogen atom or a hydroxyl-protecting group, R is a group of the formula --CH.sub.2 --X (in which X is a substituent such as a hydroxyl group), a carboxyl group or a protected carboxyl group, A.sup.1 is an aryl group, a lower alkyl group or an aralkyl group, and Z.sup.1, Z.sup.2, Z.sup.3 and Z.sup.4 each is a hydrogen atom, a hydroxyl group or a protected hydroxyl group.The above steroid compounds are useful as intermediates for the synthesis of vitamin D.sub.3 derivatives having a hydroxyl group at the 1.alpha.-position.
    Type: Grant
    Filed: March 5, 1990
    Date of Patent: June 8, 1993
    Assignee: Kuraray Co., Ltd.
    Inventors: Jiro Tsuji, Takashi Takahashi, Masao Tsuji, Naoshi Nakagawa, Tetsuo Takigawa
  • Patent number: 5112998
    Abstract: There are provided pregnane derivatives represented by formula ##STR1## wherein A.sup.1 represents a hydrogen atom or a hydroxyl group, A.sup.2 represents a substituent such as a hydroxyl group when A.sup.1 represents a hydrogen atom, or A.sup.2 represents a hydrogen atom when A.sup.1 represents a hydroxyl group, or A.sup.1 and A.sup.2 are combined together to form an oxo group; D.sup.1 represents a substitutent such as a hydroxyl group, and D.sup.2 represents a hydrogen atom, or D.sup.1 and D.sup.2 are combined together to form an epoxy group or a single bond; D.sup.3, D.sup.5 and D.sup.7 each represents a hydrogen atom, D.sup.4 represents a hydroxyl group, and D.sup.6 represents a substitutent such as a hydroxyl group, or D.sup.3 and D.sup.4 may be combined together to form an epoxy group or a single bond, or D.sup.4 and D.sup.5 may be combined together to form a single bond, or D.sup.5 and D.sup.6 may be combined together to form an epoxy group or a single bond, or D.sup.6 and D.sup.
    Type: Grant
    Filed: June 15, 1990
    Date of Patent: May 12, 1992
    Assignee: Kuraray Co., Ltd.
    Inventors: Jiro Tsuji, Takashi Takahashi, Masao Tsuji, Naoshi Nakagawa, Tetsuo Takigawa
  • Patent number: 4906768
    Abstract: A process for producing an oxime derivative, which comprises protecting the hydroxyimino group of an oxime compound with a protecting agent, subjecting the protected oxime compound to a given reaction, and thereafter deprotecting the reaction product, wherein a 2-alkenylating agent is used as the protecting agent.
    Type: Grant
    Filed: February 11, 1988
    Date of Patent: March 6, 1990
    Assignee: Nippon Zeon Co., Ltd.
    Inventors: Toshiro Yamada, Jiro Tsuji, Kuniaki Goto
  • Patent number: 4701536
    Abstract: Disclosed are a compound of Formula I: ##STR1## wherein R.sub.1 represents a hydrogen atom or a protective group for a hydroxyl group; and Z represents a direct bond (2,3-cis-5R*, 8S*) or an oxygen atom which forms an oxirane ring having a configuration of (2R*, 3R*, 5R*, 8S*),and a process for preparing the same.By use of the above compound as an intermediate, there can be synthesized periplanone-B which is a sex pheromone of periplaneta.
    Type: Grant
    Filed: July 7, 1986
    Date of Patent: October 20, 1987
    Assignee: UBE Industries, Ltd.
    Inventors: Jiro Tsuji, Takashi Takahashi
  • Patent number: 4575570
    Abstract: A process for producing alpha,beta-unsaturated ketones represented by the following general formula ##STR1## wherein R.sub.1 represents a hydrocarbon radical, R.sub.2 represents an organic radical bonded through a carbon-carbon bond, R.sub.3 and R.sub.4 represent a hydrogen atom or a hydrocarbon radical, and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be straight-chained or form a ring in arbitrary combinations,which comprises contacting an alpha-disubstituted-beta-keto acid ester represented by the general formula ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined, and R.sub.5, R.sub.6, R.sub.7 and R.sub.8 represent a hydrogen atom or a hydrocarbon radical,with a catalyst consisting essentially of (a) a compound of a platinum-group metal and optionally (b) a monodentate ligand (b).
    Type: Grant
    Filed: July 31, 1984
    Date of Patent: March 11, 1986
    Assignee: Nippon Zeon Co., Ltd.
    Inventors: Hideaki Kataoka, Toshiro Yamada, Kuniaki Goto, Jiro Tsuji
  • Patent number: 4496766
    Abstract: A process for producing an .alpha.,.beta.-unsaturated ketone of the general formula ##STR1## wherein R.sub.1 represents a hydrocarbon group, R.sub.2 represents an organic group bonded through a carbon-carbon bond, R.sub.3 and R.sub.4 represent a hydrogen atom or a hydrocarbon group, and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be linear or may form a ring when taken together in arbitrary combinations,which comprises contacting an .alpha.-disubstituted-.beta.-keto acid ester of the general formula ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined, and R.sub.5, R.sub.6 and R.sub.7 represent a hydrogen atom or a hydrocarbon group,with a catalyst consisting essentially of (a) a compound of a platinum-group metal and (b) and .alpha.,.omega.-alkylenedi(disubstituted)phosphine.
    Type: Grant
    Filed: May 4, 1983
    Date of Patent: January 29, 1985
    Assignee: Nippon Zeon Co. Ltd.
    Inventors: Jiro Tsuji, Isao Shimizu
  • Patent number: 4267376
    Abstract: A compound having the general formula ##STR1## wherein R.sup.1 is a lower alkyl group, R.sup.2 is hydrogen or a lower alkyl group and Y is a protected hydroxyl group, for example, (.+-.)-3.beta.-tert.butoxy-2,3,3a,4,5,7,8,9,9a.beta.,9b.alpha.-decahydro-3 a.beta.-methyl-6-(3-butenyl)-1H-benz(e)inden-7-one, which is an intermediate for steroids, is prepared by dehydrative cyclization of a compound of the general formula ##STR2## wherein the symbols of R.sup.1, Y and R.sup.2 are same as defined above.
    Type: Grant
    Filed: August 30, 1979
    Date of Patent: May 12, 1981
    Assignee: Takeda Chemical Industries, Ltd.
    Inventor: Jiro Tsuji
  • Patent number: 4267377
    Abstract: A compound of the general formula: ##STR1## wherein R.sup.1 is a lower alkyl group; R.sup.2 is H or a lower alkyl group; Y is an oxo group, H or an unprotected or protected hydroxyl group; X is a methylene or ethylene group, for example, 7,7a-dihydro-7aS-methyl-4-(3-butenyl)-1-tert. butoxy-5(6H)-indanone, which is an intermediate for steroids, is prepared by dehydrative cyclization of a compound of the general formula of ##STR2## wherein R.sup.1, R.sup.2, X and Y are the same as above.
    Type: Grant
    Filed: August 30, 1979
    Date of Patent: May 12, 1981
    Assignee: Takeda Chemical Industries, Ltd.
    Inventor: Jiro Tsuji
  • Patent number: 4181683
    Abstract: 1,7-Octadien-3-one of the formula: ##STR1## and a process for preparing the same by oxidizing 1,7-octadien-3-ol.
    Type: Grant
    Filed: October 6, 1978
    Date of Patent: January 1, 1980
    Assignee: Mitsubishi Petrochemical Co., Ltd.
    Inventor: Jiro Tsuji