Abstract: A biosensing platform for in-situ sampling and target detection based on upconversion luminescence, including: an upconversion luminescent paper-based microfluidic device, an upconversion luminescent biosensor, and a portable detection device based on smartphone imaging. The upconversion luminescent paper-based microfluidic device is configured to sample a to-be-detected substance in situ. The upconversion luminescent biosensor is configured to allow a target to specifically recognize the to-be-detected substance. The portable detection device is configured to detect a content of the to-be-detected substance. The upconversion luminescent biosensor is prepared as follows. (S1) An upconversion nanoparticle seed is prepared. (S2) Core-shell upconversion nanoparticles are prepared. (S3) Core-shell-shell upconversion nanoparticles (UCNPs) are prepared. (S4) The UCNPs is subjected to hydrophilic modification. (S5) The hydrophilically-modified UCNPs are modified with DNA.

Abstract: Various systems and methods are described for a variable geometry turbine. In one example, a nozzle vane includes a stationary having a first cambered sliding surface and a sliding vane having a second cambered sliding surface where the second cambered sliding surface includes a flow disrupting feature in contact with the first sliding cambered surface. The sliding vane may be positioned to slide in a direction from substantially tangent along a curved path to an inner circumference of the turbine nozzle and selectively uncover the flow disrupting feature.

Abstract: Various systems and methods are described for a variable geometry turbine. In one example, a nozzle vane includes a stationary having a first cambered sliding surface and a sliding vane having a second cambered sliding surface where the second cambered sliding surface includes a flow disrupting feature in contact with the first sliding cambered surface. The sliding vane may be positioned to slide in a direction from substantially tangent along a curved path to an inner circumference of the turbine nozzle and selectively uncover the flow disrupting feature.

Abstract: Various systems and methods are described for a variable geometry turbine. In one example, a nozzle vane includes a stationary having a first cambered sliding surface and a sliding vane having a second cambered sliding surface where the second cambered sliding surface includes a flow disrupting feature in contact with the first sliding cambered surface. The sliding vane may be positioned to slide in a direction from substantially tangent along a curved path to an inner circumference of the turbine nozzle and selectively uncover the flow disrupting feature.

Abstract: Various systems and methods are described for a variable geometry turbine. In one example, a nozzle vane includes a stationary having a first cambered sliding surface and a sliding vane having a second cambered sliding surface where the second cambered sliding surface includes a flow disrupting feature in contact with the first sliding cambered surface. The sliding vane may be positioned to slide in a direction from substantially tangent along a curved path to an inner circumference of the turbine nozzle and selectively uncover the flow disrupting feature.

Abstract: Various systems and methods are described for a variable geometry turbine. In one example, a turbine nozzle comprises a central axis and a nozzle vane. The nozzle vane includes a stationary vane and a sliding vane. The sliding vane is positioned to slide in a direction substantially tangent to an inner circumference of the turbine nozzle and in contact with the stationary vane.

Abstract: In one example, a turbocharger for an internal combustion engine is described. The turbocharger comprises a casing containing an impeller having a full blade coupled to a hub that rotates about an axis of rotation. The casing includes a bleed port and an injection port. The full blade includes a hub edge, a casing edge, and a first distribution of angles, each angle measured between the axis of rotation and a mean line at the hub edge at a meridional distance along the hub edge. The full blade includes a second distribution of angles, each angle measured between the axis of rotation and a mean line at the casing edge at a meridional distance along the casing edge. Further, various systems are described for affecting the aerodynamic properties of the compressor and turbine components in a way that may extend the operating range of the turbocharger.

Abstract: Various systems and methods are described for a variable geometry turbine. In one example, a turbine nozzle comprises a central axis and a nozzle vane. The nozzle vane includes a stationary vane and a sliding vane. The sliding vane is positioned to slide in a direction substantially tangent to an inner circumference of the turbine nozzle and in contact with the stationary vane.

Abstract: The present invention relates to a drop pill for treating coronary heart disease, comprising an active pharmaceutical ingredient (API), a matrix adjuvant, a plastifying adjuvant, propylene glycol and water. the API is prepared from Radix salvia miltiorrhira, Panax notoginseng and Borneol; the matrix adjuvant is erythritol; the plastifying adjuvant is one or more selected from the group consisting of polyethylene glycols, xylitol, lactitol, mannitol, glycerine, soluble amylum, gelatin, methyl cellulose, sodium carboxymethycellulose (CMC-Na), hydroxypropyl methylcellulose (HPMC), arabic gum, alginic acid, dextrin, cyclodextrin (CD), citrate, glycerol acetate, dibutyl sebacate, refined coconut oil and castor oil; Wherein, relative to the total weight of the drop pill, the API is 1˜40 wt %, the plastifying adjuvant 0˜10 wt %, the propylene glycol 1˜10 wt %, the water 0˜10 wt % and the balance is the matrix adjuvant.

Abstract: In one example, a turbocharger for an internal combustion engine is described. The turbocharger comprises a casing containing an impeller having a full blade coupled to a hub that rotates about an axis of rotation. The casing includes a bleed port and an injection port. The full blade includes a hub edge, a casing edge, and a first distribution of angles, each angle measured between the axis of rotation and a mean line at the hub edge at a meridional distance along the hub edge. The full blade includes a second distribution of angles, each angle measured between the axis of rotation and a mean line at the casing edge at a meridional distance along the casing edge. Further, various systems are described for affecting the aerodynamic properties of the compressor and turbine components in a way that may extend the operating range of the turbocharger.

Abstract: A highly immunoreactive viral peptide, pE2, is disclosed which is derived from the carboxy-terminal end region of ORF2 region of the hepatitis E virus (HEV) genome. A unique feature of the novel pE2 peptide is that it possesses conformational antigenic determinants which are only exposed when monomers of the peptide associate with one another through non-covalent interactions to naturally form homodimers. The novel pE2 peptide is proven to be highly reactive with sera from patients having current or past infection with HEV which suggests that the homodimer may mimic certain structural features of the HEV capsid protein. Furthermore, the antigenic activity of the pE2 peptide is strictly conformational in nature and therefore, exhibits immunochemical reactivity only when the peptide exists in a dimeric form. Consequently, the antigenic activity is lost upon dissociation of the dimers, but the activity is restored when the monomers reassociate to form dimers.