Patents by Inventor Joachim Fruebis

Joachim Fruebis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR COUNTERACTING FACTOR XA INHIBITION
    Publication number: 20210000930
    Abstract: The disclosure provides compositions and methods for counteracting the effects of direct activated Factor X (FXa) inhibitors in a subject by administering a variant of FXa.
    Type: Application
    Filed: March 16, 2020
    Publication date: January 7, 2021
    Inventors: Debra D. Pittman, Rodney M. Camire, Joachim Fruebis
  • Compositions and methods for counteracting Factor Xa inhibition
    Patent number: 10588950
    Abstract: The disclosure provides compositions and methods for counteracting the effects of direct activated Factor X (FXa) inhibitors in a subject by administering a variant of FXa.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: March 17, 2020
    Assignee: PFIZER INC.
    Inventors: Debra D. Pittman, Rodney M. Camire, Joachim Fruebis
  • COMPOSITIONS AND METHODS FOR TREATING INTRACEREBRAL HEMORRHAGE
    Publication number: 20190231856
    Abstract: The disclosure provides compositions and methods for treating or preventing intracerebral hemorrhage (ICH) in a subject by administering a variant of FXa.
    Type: Application
    Filed: October 11, 2018
    Publication date: August 1, 2019
    Inventors: Steven Arkin, Marcus Carr, Joachim Fruebis, Sunita Hett, Reema Jasuja, Debra Pittman
  • COMPOSITIONS AND METHODS FOR COUNTERACTING FACTOR XA INHIBITION
    Publication number: 20180344819
    Abstract: The disclosure provides compositions and methods for counteracting the effects of direct activated Factor X (FXa) inhibitors in a subject by administering a variant of FXa.
    Type: Application
    Filed: January 17, 2018
    Publication date: December 6, 2018
    Inventors: Debra D. Pittman, Rodney M. Camire, Joachim Fruebis
  • COMPOSITIONS AND METHODS FOR TREATING INTRACEREBRAL HEMORRHAGE
    Publication number: 20160375109
    Abstract: The disclosure provides compositions and methods for treating or preventing intracerebral hemorrhage (ICH) in a subject by administering a variant of FXa.
    Type: Application
    Filed: January 15, 2015
    Publication date: December 29, 2016
    Inventors: Steven Arkin, Marcus Carr, Joachim Fruebis, Sunita Hett, Reema Jasuja, Debra Pittman
  • COMPOSITIONS AND METHODS FOR COUNTERACTING FACTOR XA INHIBITION
    Publication number: 20150343034
    Abstract: The disclosure provides compositions and methods for counteracting the effects of direct activated Factor X (FXa) inhibitors in a subject by administering a variant of FXa.
    Type: Application
    Filed: January 23, 2014
    Publication date: December 3, 2015
    Inventors: Debra D. Pittman, Rodney M. Camire, Joachim Fruebis
  • OBG3 globular head and uses thereof
    Patent number: 7671024
    Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. The application is related to OBG3 polypepide fragments and compositions comprising these fragments. It also discloses methods of reducing free fatty acid levels with the polypeptide fragments of the invention.
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: March 2, 2010
    Assignee: Serono Genetics Institute S.A.
    Inventors: Joachim Fruebis, Mary Ruth Erickson, Frances Yen-Potin, Bernard Bihain
  • OBG3 Globular Head and Uses Thereof
    Publication number: 20090099076
    Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidermias, atherosclerosis, diabetes, and hypertension.
    Type: Application
    Filed: May 23, 2008
    Publication date: April 16, 2009
    Applicant: Serono Genetics Institute S.A.
    Inventors: Joachim Fruebis, Mary Ruth Erickson, Frances Yen-Potin, Bernard Bihain
  • Isolated polypeptide comprising a leptin fragment
    Patent number: 7470669
    Abstract: The present invention is drawn to methods of screening for new compounds for the treatment of obesity and obesity-related diseases and disorders, as well as methods of treating obesity-related diseases and disorders, based on the discovery of the role of the leptin-LSR interaction in obesity.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: December 30, 2008
    Assignee: Serono Genetics Institute, S.A.
    Inventors: Frances Yen, Mary Ruth Erickson, Joachim Fruebis, Bernard Bihain
  • Use of ACRP30 Globular Head to Promote Increases in Muscle Mass and Muscle Differentiation
    Publication number: 20080274971
    Abstract: The present invention relates to the field of muscle research, in particular to the discovery of a compound effective for increasing muscle mass, muscle cell differentiation, and oxidation of free fatty acids in muscle, useful in methods of treating muscle-related diseases and disorders as well as for augmenting muscle mass in general. The muscle-related diseases or disorders envisaged to be treated by the methods of the invention include, but are not limited to, muscular dystrophy, and other conditions resulting in muscle atrophy or muscle wasting.
    Type: Application
    Filed: June 27, 2008
    Publication date: November 6, 2008
    Applicant: SERONO GENETICS INSTITUTE S.A.
    Inventors: Harvey Lodish, Joachim Fruebis, Tsu-Shuen Tsao, Bernard Bihain
  • PROK2 ANTAGONISTS AND METHODS OF USE
    Publication number: 20080219985
    Abstract: The present invention provides methods of using PROK2 and PROK1 antagonist, including monoclonal antibodies to treat inflammation, angiogenesis, and cancer.
    Type: Application
    Filed: September 13, 2006
    Publication date: September 11, 2008
    Inventors: Penny J. Thompson, Anthony W. Siadak, Claire R. Noriega, Henry R. Franklin, Secil Oguz, Deborah L. Thompson, Stavros Topouzis, Joachim Fruebis, Kenneth Brasel, Yue Yao
  • Use of Acrp30 globular head to promote increases in muscle mass and muscle differentiation
    Patent number: 7405193
    Abstract: The present invention relates to the field of muscle research, in particular to the discovery of a compound effective for increasing muscle mass, muscle cell differentiation, and oxidation of free fatty acids in muscle, useful in methods of treating muscle-related diseases and disorders as well as for augmenting muscle mass in general. The muscle-related diseases or disorders envisaged to be treated by the methods of the invention include, but are not limited to, muscular dystrophy, and other conditions resulting in muscle atrophy or muscle wasting.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: July 29, 2008
    Assignee: Serono Genetics Institute S.A.
    Inventors: Harvey Lodish, Joachim Fruebis, Tsu-Shuen Tsao, Bernard Bihain
  • Nucleic acids encoding OBG3 polypeptides
    Patent number: 7393661
    Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. This application pertains to nucleic acids encoding a compound, globular OBG3 polypeptide fragments, vectors and transformed host cells containing these nucleic acids and methods of making the globular OBG3 polypeptide fragments.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: July 1, 2008
    Assignee: Serono Genetics Institute S.A.
    Inventors: Joachim Fruebis, Mary Ruth Erickson, Frances Yen-Potin, Bernard Bihain
  • Nucleic acids encoding OBG3 globular head and uses thereof
    Patent number: 7338787
    Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: March 4, 2008
    Assignee: Serono Genetics Institute S.A.
    Inventors: Joachim Fruebis, Mary Ruth Erickson, Frances Yen-Potin, Bernard Bihain
  • OBG3 globular head and uses thereof
    Publication number: 20070275891
    Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.
    Type: Application
    Filed: May 19, 2005
    Publication date: November 29, 2007
    Applicant: Genset S.A.
    Inventors: Joachim Fruebis, Mary Erickson, Frances Yen-Potin, Bernard Bihain
  • Inhibitors for use in hemostasis
    Publication number: 20060252692
    Abstract: The present invention relates to peptide, polynucleotide and fusion proteins for use as inhibitors in hemostasis. These inhibitors are members of the family of proteins bearing a collagen-like domain and a globular domain. The inhibitors are useful for promoting blood flow in the vasculature by reducing thrombogenic and complement activity. The inhibitors are also useful for pacify collagenous surfaces and modulating wound healing.
    Type: Application
    Filed: June 29, 2006
    Publication date: November 9, 2006
    Inventors: Gerald Lasser, Paul Bishop, Joachim Fruebis, Woerner Meehan
  • Use of acrp30 globular head to promote increases in muscle mass and muscle differentiation
    Publication number: 20060035824
    Abstract: The present invention relates to the field of muscle research, in particular to the discovery of a compound effective for increasing muscle mass, muscle cell differentiation, and oxidation of free fatty acids in muscle, useful in methods of treating muscle-related diseases and disorders as well as for augmenting muscle mass in general. The muscle-related diseases or disorders envisaged to be treated by the methods of the invention include, but are not limited to, muscular dystrophy, and other conditions resulting in muscle atrophy or muscle wasting.
    Type: Application
    Filed: May 22, 2001
    Publication date: February 16, 2006
    Applicant: Genset
    Inventors: Harvey Lodish, Joachim Fruebis, Tsu-Shuen Tsao, Bernard Bihain
  • Methods of screening for compounds that modulate the LSR-leptin interaction and their use in the prevention and treatment of obesity-related diseases
    Publication number: 20060030530
    Abstract: The present invention is drawn to methods of screening for new compounds for the treatment of obesity and obesity-related diseases and disorders, as well as methods of treating obesity-related diseases and disorders, based on the discovery of the role of the leptin-LSR interaction in obesity.
    Type: Application
    Filed: September 27, 2005
    Publication date: February 9, 2006
    Applicant: Serono Genetics Institute S.A.
    Inventors: Frances Yen, Bernard Bihain, Mary Erickson, Joachim Fruebis
  • OBG3 globular head and uses thereof
    Patent number: 6989367
    Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.
    Type: Grant
    Filed: November 1, 2002
    Date of Patent: January 24, 2006
    Assignee: Genset S.A.
    Inventors: Joachim Fruebis, Mary Ruth Erickson, Frances Yen-Potin, Bernard Bihain
  • OBG3 globular head and uses thereof for decreasing body mass
    Patent number: 6967091
    Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: November 22, 2005
    Assignee: Genset, S.A.
    Inventors: Joachim Fruebis, Mary Ruth Erickson, Frances Yen, Bernard Bihain