Patents by Inventor Jochen Knolle

Jochen Knolle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5703050
    Abstract: Urea derivates are disclosed having the formula (I). ##STR1## in which A, B, W, Z, R, R.sup.1, R.sup.2, R.sup.3 and r have the meaning given in the description, as well as a process for preparing the same and their use as inhibitors of thrombocyte aggregation, carcinom cell metastasis and osteoclast binding to bone surface.
    Type: Grant
    Filed: January 17, 1996
    Date of Patent: December 30, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Otmar Klingler, Gerhard Zoller, Bernd Jablonka, Melitta Just, Gerhard Breipohl, Jochen Knolle, Wolfgang Konig, Hans Ulrich Stilz
  • Patent number: 5681838
    Abstract: The present invention relates to novel substituted amino compounds of the formula I:R.sup.1 -(A).sub.a -(B).sub.b -(D).sub.c -(CH.sub.2).sub.m -N(R.sup.2)-(CH.sub.2).sub.n -R.sup.3as defined in the present application, and to a process for preparing such compounds. The invention also includes pharmaceutical compositions containing the present compounds, and the preparation of such compositions. The invention also relates to the use of the present compounds as inhibitors of blood-platelet aggregation, formation of metastases by carcinoma cells, and the binding of osteoclasts to bone surfaces, in the treatment of hosts in need thereof.
    Type: Grant
    Filed: July 18, 1995
    Date of Patent: October 28, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Zoller, Bernd Jablonka, Melitta Just, Otmar Klingler, Gerhard Breipohl, Jochen Knolle, Wolfgang Konig
  • Patent number: 5658935
    Abstract: The invention concerns heterocyclic compounds of the general formula (I) in which A, B, R, R.sup.2, R.sup.3, W, Y, Z.sup.1, Z.sup.2 and r are as defined in the description, methods of preparing them and their use as inhibitors of thrombocyte aggregation, the metastization of carcinoma cells and the binding of osteoclasts on bone surfaces.
    Type: Grant
    Filed: January 17, 1996
    Date of Patent: August 19, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Otmar Klingler, Gerhard Zoller, Bernd Jablonka, Melitta Just, Gerhard Breipohl, Jochen Knolle, Wolfgang Konig
  • Patent number: 5648333
    Abstract: Peptides of the formula IA-B-C-E-F-K-P-G-M-F'-I (I),wherein the terms A, B, C, E, F, K, P, G, M, F', and I are defined in the specification, have bradykinin antagonist action. Their therapeutic utility includes all pathological states which are mediated, caused or supported by bradykinin and bradykinin-related peptides.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 15, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stephan Henke, Hiristo Anagnostopulos, Gerhard Breipohl, Jochen Knolle, Jens Stechl, Bernward Scholkens, Hans-Wolfram Fehlhaber, Hermann Gerhards, Franz Hock
  • Patent number: 5597803
    Abstract: Peptides of the formula IZ-P-A-B-C-E-F-K-(D)Q-G-M-F'-I (I)and the physiologically tolerated salts thereof, are described.They have an excellent bradykinin-antagonistic action.They are obtained by reacting reacting a fragment with a C-terminal free carboxyl group or its activated derivative with a corresponding fragment with an N-terminal free amino group or assembling the peptide stepwise, where appropriate eliminating in the compound obtained in this way one or more protective groups introduced temporarily to protect other functionalities, and where appropriate converting the compounds of the formula I obtained in this way into the physiologically tolerated salt thereof.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: January 28, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Breipohl, Stephan Henke, Jochen Knolle, Bernward Scholkens, Hans-Georg Alpermann, Hermann Gerhards, Klaus Wirth
  • Patent number: 5565606
    Abstract: The invention relates to compounds of the formula I ##STR1## in which A denotes hydrogen or an amino protective group, B denotes one or more amino acids, X denotes alkylene or aralkylene, Y.sup.1, Y.sup.2, Y.sup.3 and Y.sup.4 are identical or different and denote hydrogen, methyl, methoxy or nitro, V denotes hydrogen or a carboxyl protective group, W denotes --[CH.sub.2 ].sub.n -- or --O--[CH.sub.2 ].sub.n --, m denotes 0 or 1, n denotes 0 to 6, and p denotes 0 to 5, to a process for their preparation. The compounds of formula I are useful as linkage agents or anchor groups in the solid-phase synthesis of peptide aminoalkylamides and peptide hydrazides.
    Type: Grant
    Filed: June 8, 1994
    Date of Patent: October 15, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Breiphol, Jochen Knolle
  • Patent number: 5554594
    Abstract: The present invention relates to compounds of the general formula I ##STR1## in which R, R.sup.1 to R.sup.4, r, Y, Z and W are defined as indicated in the description, a process for their preparation and their use as inhibitors of platelet aggregation, metastasis of carcinoma cells and osteoclast binding to the bone surfaces.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 10, 1996
    Assignee: Cassella Aktiengessellschaft
    Inventors: Gerhard Zoller, Bernd Jablonka, Melitta Just, Otmar Klingler, Gerhard Breipohl, Jochen Knolle, Wolfgang K onig
  • Patent number: 5424293
    Abstract: Phenylimidazolidine derivatives of the general formula I ##STR1## in which, for example, Y denotes --CH.sub.2 --CH.sub.2 --CO--r denotes 0 to 3Z denotes oxygenW denotes hydroxylR.sup.1 denotes --NH--C(.dbd.NH)--NH.sub.2R, R.sup.2, R.sup.3 denote hydrogenR.sup.4 denotes --CO--NHR.sup.5,where --NH--R.sup.5 represents an .alpha.-amino acid radical, have useful pharmacological properties such as inhibition of platelet aggregation and osteoclast binding to the bone surfaces.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: June 13, 1995
    Assignee: Cassella AG
    Inventors: Gerhard Zoller, Bernd Jablonka, Melitta Just, Otmar Klingler, Gerhard Breipohl, Jochen Knolle, Wolfgang Konig
  • Patent number: 5397796
    Abstract: The present invention relates to 2,4-dioxoimidazolidine compounds of the formula I ##STR1## a process for their preparation and their use as inhibitors of platelet aggregation, metastasis of carcinoma cells and osteoclast binding to the bone surfaces.
    Type: Grant
    Filed: April 12, 1993
    Date of Patent: March 14, 1995
    Assignee: Cassella AG
    Inventors: Gerhard Zoller, Wolfgang Konig, Jochen Knolle, Melitta Just, Bernd Jablonka
  • Patent number: 5242908
    Abstract: The use of a compound of the formula I ##STR1## in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group, cyanide, nitro, carboxyl, hydrogen or a cycloalkyl, aryl, aralkyl or carboalkoxy group, R.sup.1 and R.sup.2 are an alkyl, alkenyl, alkynyl, cycloalkyl or halogenoalkyl group, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium or hydrogen, R.sup.1 and R.sup.2 together form a cyclic diester, R.sup.3 and R.sup.4 are an alkyl, alkenyl, alkynyl, carboalkoxy, cycloalkyl or alkoxy group, hydrogen, fluorine, chlorine, bromine or iodine and X, Y and Z are oxygen or sulfur, for the treatment of diseases caused by DNA viruses or RNA viruses is described.
    Type: Grant
    Filed: February 1, 1991
    Date of Patent: September 7, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Anuschirwan Peyman, Eugen Uhlmann, Karlheinz Budt, Jochen Knolle, Irvin Winkler, Matthias Helsberg
  • Patent number: 5124478
    Abstract: The invention relates to new compounds of the formula ##STR1## in which R.sup.1 denotes (C.sub.1 -C.sub.8)-alkyl, R.sup.2 denotes an amino acid residue which is protected with a urethane protective group which can be eliminated with weak acid or base, or denotes an amino protective group which can be eliminated with weak acid or base, R.sup.3 denotes hydrogen or (C.sub.1 -C.sub.4)-alkyl, and Y.sup.1 -Y.sup.9 denote identical or different radicals hydrogen, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy or --O--(CH.sub.2).sub.n --COOH (with n=1 to 6), with one of these radicals being --O--(CH.sub.2).sub.n --COOH, or Y.sup.1, Y.sup.2 and Y.sup.5 -Y.sup.9 denote identical or different radicals hydrogen, (C.sub.1 -C.sub.4)-alkyl or (C.sub.1 -C.sub.4)-alkoxy, Y.sup.3 denotes hydrogen or (C.sub.1 -C.sub.8)-alkoxy and Y.sup.4 denotes --(CH.sub.2).sub.n --COOH or --NH--CO--(CH.sub.2).sub.n --COOH (with n=1 to 6).
    Type: Grant
    Filed: December 20, 1988
    Date of Patent: June 23, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Breipohl, Jochen Knolle, Werner Stuber
  • Patent number: 5011825
    Abstract: The invention relates to peptides of the formulaR.sup.N --L--N--B.sup.2 --R.sup.C (I)in which R.sup.N denotes an acyl radical, L denotes a radical of a lipophilic, neutral .alpha.-amino acid, N denotes a radical of an neutral .alpha.-amino acid, B.sup.2 denotes the radical of a basic .alpha.-amino acid, and R.sup.C denotes an amido radical; a process for their preparation, agents containing these peptides, and their use.
    Type: Grant
    Filed: January 8, 1990
    Date of Patent: April 30, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wolfgang Konig, Gerhard Breipohl, Rolf Geiger, Jochen Knolle, Max Hropot
  • Patent number: 4922015
    Abstract: The invention relates to new compounds of the formula ##STR1## in which R.sup.1 denotes (C.sub.1 -C.sub.8)-alkyl or optionally substituted (C.sub.6 -C.sub.14)-aryl, R.sup.2 denotes hydrogen or an amino acid residue which is protected by an amino protective group which can be cleaved off with weak acid or base, R.sup.3 denotes hydrogen or (C.sub.1 -C.sub.4)-alkyl, and Y.sup.1 -Y.sup.9 denote identical or different radicals hydrogen, (C.sub.1 -C.sub.4)-alkyl, (C.sub.1 -C.sub.4)-alkoxy or -O-(CH.sub.2).sub.n -COOH (with n=1 to 6), one of these radicals being -O-(CH.sub.2).sub.n -COOH. A process for the preparation thereof and the synthesis of peptide amides by means of a solid phase method using these new compounds (spacers) are described.
    Type: Grant
    Filed: April 6, 1988
    Date of Patent: May 1, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Breipohl, Jochen Knolle, Werner Stuber
  • Patent number: 4861755
    Abstract: The invention relates to new peptides of the formula ##STR1## in which X, A, B, C, N', E, F, G and Z have the meanings indicated in the description, to a process for their preparation, to agents containing them, and to their use.
    Type: Grant
    Filed: January 14, 1987
    Date of Patent: August 29, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Breipohl, Jochen Knolle, Wolfgang Konig, Bernward Scholkens
  • Patent number: 4548936
    Abstract: The present invention relates to .DELTA..sup.1 -pyrroline thiolactim ethers of the general formula I ##STR1## which have a more specific action and/or a longer-lasting action than PGI.sub.2, and to a process for their preparation.The compounds are distinguished by a platelet aggregation-inhibiting action and a blood vessel-relaxing and hypotensive action, and can therefore be used as medicaments.
    Type: Grant
    Filed: May 5, 1982
    Date of Patent: October 22, 1985
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Beck, Wilhelm Bartmann, Jochen Knolle, Richard H. Rupp
  • Patent number: 4371542
    Abstract: What are disclosed are prostacylin PGI.sub.2 analogs of the formula ##STR1## having a more specific or longer lasting pharmacological action than PGI.sub.2, methods of making these analogs; and methods and pharmaceutical preparations for inhibiting blood platelet aggregation, for treating hypertension, for the treatment or prophylaxis of gastrointestinal ulcers, and for the treatment of asthma.
    Type: Grant
    Filed: February 20, 1981
    Date of Patent: February 1, 1983
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Beck, Jochen Knolle, Richard H. Rupp, Bernward Scholkens