Patents by Inventor Joel Morris

Joel Morris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted bicyclic derivatives useful as anticancer agents
    Patent number: 6541481
    Abstract: The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: April 1, 2003
    Assignee: Pfizer Inc
    Inventors: John Charles Kath, Norma Jacqueline Tom, Zhengyu Liu, Eric David Cox, Joel Morris, Samit Kumar Bhattacharya
  • Bicyclic-substituted 4-amino-pyridopyrimidine derivatives
    Publication number: 20030045535
    Abstract: The invention relates to 6- or 7-bicyclic-substituted 4-amino-subsituted pyridopyrimidines and to pharmaceutically acceptable salts, prodrugs and hydrates thereof. The invention also relates to pharmaceutical compositions containing the compounds and to methods of treating hyperproliferative disorders abnormal cell growth in a mammal by administering the compounds.
    Type: Application
    Filed: April 12, 2002
    Publication date: March 6, 2003
    Applicant: Pfizer Inc.
    Inventors: Joel Morris, Samit K. Bhattacharya, John C. Kath
  • Substituted bicyclic derivatives for the treatment of abnormal cell growth
    Publication number: 20020169165
    Abstract: The invention relates to compounds of the formula 1 1
    Type: Application
    Filed: June 18, 2001
    Publication date: November 14, 2002
    Inventors: John Charles Kath, Joel Morris, Samit Kumar Bhattacharya
  • Substituted bicyclic derivatives useful as anticancer agents
    Publication number: 20010034351
    Abstract: The invention relates to compounds of the formula 1 1
    Type: Application
    Filed: April 12, 2001
    Publication date: October 25, 2001
    Inventors: John Charles Kath, Norma Jacqueline Tom, Zhengyu Liu, Eric David Cox, Joel Morris, Samit Kumar Bhattacharya
  • Substituted bicyclic derivatives useful as anticancer agents
    Patent number: 6284764
    Abstract: The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X, R1, R3 and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals with administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: September 4, 2001
    Assignee: Pfizer Inc.
    Inventors: John Charles Kath, Norma Jacqueline Tom, Zhengyu Liu, Eric David Cox, Joel Morris, Samit Kumar Bhattacharya
  • Compounds useful to treat retroviral infections
    Patent number: 6169181
    Abstract: The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus.
    Type: Grant
    Filed: November 9, 1998
    Date of Patent: January 2, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Karen Rene Romines, Gordon L. Bundy, Theresa M. Schwartz, Ruben A. Tommasi, Joseph W. Strohbach, Steven Ronald Turner, Suvit Thaisrivongs, Paul Adrian Aristoff, Paul D. Johnson, Harvey Irving Skulnick, Louis L. Skaletzky, David John Anderson, Joel Morris, Ronald B. Gammill, George P. Luke
  • Thioalkyl alpha substituted pyrimidine compounds
    Patent number: 6124306
    Abstract: The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I ##STR1## and pyrimidine-thioalkyl and alkylethers of Formula I, where R.sub.4 is selected from the group consisting of --H or --NR.sub.15 R.sub.16 where R.sub.15 is --H and R.sub.16 is --H, C.sub.1 -C.sub.6 alkyl, --NH.sub.2 or R.sub.15 and R.sub.16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; andR.sub.6 is --S--C.sub.1-6 alkyl (preferably --SCH.sub.3);The compounds of Formula I are useful in the treatment of individuals who are HIV positive.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: September 26, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Joel Morris, Wade J. Adams, Janice M. Friis, Donn G. Wishka
  • Substituted aminophenyl isoxazoline derivatives useful as antimicrobials
    Patent number: 6069141
    Abstract: The present invention provides novel substituted amionphenyl isoxazoline derivatives of formula I ##STR1## wherein R.sub.1 is H, alkyl, cycloalkyl, alkoxy, amino, or alkylamino; X and Y are the same and different and are H, F, or CH.sub.3 ; W is O, or S;Q is a 4-, 5-, 6-, 7-, or 9-membered heterocyclic moiety containing one or more nitrogen, sulfur and/or oxygen. The compounds of the invention are useful as antimicrobial agents for preventing and treating infectious diseases.
    Type: Grant
    Filed: February 3, 1999
    Date of Patent: May 30, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael Robert Barbachyn, Joel Morris, Donn G. Wishka, Gary J. Cleek, Richard Charles Thomas
  • Alpha-substituted pyrimidine-thioalkyl and alkylether compounds as inhibitors of viral reverse transcriptase
    Patent number: 6043248
    Abstract: The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R.sub.4 is selected from the group consisitng of --H or --NR.sub.15 R.sub.16 where R.sub.15 is --H and R.sub.16 is --H, C.sub.1 -C.sub.6 alkyl, NH.sub.2 or R.sub.15 and R.sub.16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R.sub.6 is selected from the group consisting of --H, or halo (preferably --Cl); with the overall proviso that R.sub.4 and R.sub.6 are not both --H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive being inhibitors of viral reverse transcriptase.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: March 28, 2000
    Assignee: Pharmacia & Upjohn Company
    Inventors: Richard A. Nugent, Stephen T. Schlachter, Michael J. Murphy, Joel Morris, Richard C. Thomas, Donn G. Wishka, Gary J. Cleek, David R. Graber
  • Pyrimidine-thioalkyl and alkylether compounds
    Patent number: 5981537
    Abstract: The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R.sup.4 is selected from the group consisting of --H or --NR.sub.15 R.sub.16 where R.sub.15 is --H and R.sub.16 is --H, C.sub.1 -C.sub.6 alkyl, --NH.sub.2 or R.sub.15 and R.sub.16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R.sub.6 is selected from the group consisting of --H, or halo (preferably --Cl); with the overall proviso that R.sub.4 and R.sub.6 are not both --H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive.
    Type: Grant
    Filed: May 9, 1996
    Date of Patent: November 9, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Richard A. Nugent, Stephen T. Schlachter, Michael J. Murphy, Joel Morris, Richard C. Thomas, Donn G. Wishka, Fritz Reusser, Gary J. Cleek, Irene W. Althaus
  • Pyranone compounds useful to treat retroviral infections
    Patent number: 5852195
    Abstract: The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl?b!pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R.sub.10 and R.sub.20 taken together are formulae (III) and (IV).
    Type: Grant
    Filed: November 4, 1996
    Date of Patent: December 22, 1998
    Assignee: Pharmacia & Upjohn Company
    Inventors: Karen Rene Romines, Gordon L. Bundy, Theresa M. Schwartz, Ruben A. Tommasi, Joseph W. Strohbach, Steven Ronald Turner, Suvit Thaisrivongs, Paul Adrian Aristoff, Paul D. Johnson, Harvey Irving Skulnick, Louis L. Skaletzky, David John Anderson, Joel Morris, Ronald B. Gammill, George P. Luke
  • Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
    Patent number: 5703075
    Abstract: This invention relates to compounds of Formula I ##STR1## which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. In addition, various compounds of Formula I are useful inhibitors of cell proliferation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 30, 1997
    Assignee: Pharmacia & Upjohn Company
    Inventors: Ronald B. Gammill, Thomas M. Judge, Joel Morris
  • Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
    Patent number: 5302613
    Abstract: This invention relates to compounds of Formula I ##STR1## which are useful as antiatherosclerotic agents and inhibitors of cell proliferation for the treatment of proliferative diseases. In addition, various compounds of Formula I are useful inhibitors of platelet aggregation.
    Type: Grant
    Filed: April 9, 1993
    Date of Patent: April 12, 1994
    Assignee: The Upjohn Company
    Inventor: Joel Morris
  • Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
    Patent number: 5252735
    Abstract: This invention relates to compounds of Formula I ##STR1## which are useful as antiatherosclerotic agents and inhibitors of cell proliferation for the treatment of proliferative diseases. In addition, various compounds of Formula I are useful inhibitors of platelet aggregation.
    Type: Grant
    Filed: February 25, 1992
    Date of Patent: October 12, 1993
    Assignee: The Upjohn Company
    Inventor: Joel Morris
  • Antiinflammatory leukotriene B.sub.4 analogs
    Patent number: 5116981
    Abstract: This invention encompasses novel analogs of Leukotriene B.sub.4 which are selected from a compound of formula I, B--C.apprxeq.C--CH.sub.2 C(M.sub.2)--C.apprxeq.C--Y--C(M.sub.1)--A, or formula II, B--C.apprxeq.C--CH.sub.2 C(M.sub.2)--C.apprxeq.C--P--R.sub.5 --A: wherein Y is: ##STR1## wherein P is: ##STR2## Patentable intermediates, process for making the novel analogs and intermediates and preparation of useful pharmacological agents comprising the analogs and intermediates are part of this invention.
    Type: Grant
    Filed: June 29, 1989
    Date of Patent: May 26, 1992
    Assignee: The Upjohn Company
    Inventor: Joel Morris
  • Anti-inflammatory lipoxin B analogs
    Patent number: 4576758
    Abstract: The present invention relates to analogs of lipoxin B (LX-B) and discloses the anti-inflammatory uses for these analogs. Particularly, the present invention relates to analogs of 5D,14,15-trihydroxy-6,8,10,12-eicosatetraenoic acid, including certain 5-epi-, 8,9-didehydro-, 6-iso, 6,7-dihydro-7.alpha.-hydroxy, and 6,7-dihydro-7.beta.-hydroxy derivatives.
    Type: Grant
    Filed: June 1, 1984
    Date of Patent: March 18, 1986
    Assignee: The Upjohn Company
    Inventor: Joel Morris