Patents by Inventor Joelle L. Burgess

Joelle L. Burgess has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100179143
    Abstract: Invented is a method of inhibiting the activity/function of PI3 kinases using naphthyridine derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of naphthyridine derivatives.
    Type: Application
    Filed: May 29, 2008
    Publication date: July 15, 2010
    Inventors: Nicholas D. Adams, Joelle L. Burgess, Amita M. Chaudhari, David Knight, Cynthia A. Parrish
  • Patent number: 7482455
    Abstract: 3-carboxy quinoline derivatives, which are useful as YAK3 inhibitors are described herein. The described invention also includes methods of making such 3-carboxy quinoline derivatives as well as methods of using the same in the treatment of diseases mediated by inappropriate YAK3 activity.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: January 27, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Joelle L. Burgess, James F. Callahan, Toshihiro Hamajima, Satoru Ida, Ichiro Mori, Jun Tang
  • Patent number: 7166639
    Abstract: The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-? phosphorylation of I?B. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-?B in which diseases excessive activation of NF-?B is implicated.
    Type: Grant
    Filed: October 4, 2002
    Date of Patent: January 23, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Zehong Wan, Joelle L. Burgess, James F. Callahan
  • Patent number: 7109238
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: September 19, 2006
    Assignees: Smith Kline Beecham Corporation, NPS Pharmaceuticals, Inc.
    Inventors: Maria Amparo Lago, James Francis Callahan, Pradip Kumar Bhatnagar, Eric G. Del Mar, William M. Bryan, Joelle L. Burgess
  • Patent number: 7087758
    Abstract: This invention relates to novel quinoline inhibitors of hYAK1 and hYAK3 kinases and pharmaceutically acceptable salts, hydrates or solvates thereof, pharmaceutical compositions thereof, and methods of treatment of diseases in which an excessive amount of either such kinase is a factor.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: August 8, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Deborah L. Bryan, Joelle L. Burgess, James F. Callahan
  • Publication number: 20040192943
    Abstract: The present invention provides novel compounds and methods for using them to treat diseases with aminothiophene inhibitors of IKK-&bgr; phosphorylation of I&kgr;B. In so doing these aminothiophene inhibitors block pathological activation of transcription factor NF-&kgr;B in which diseases excessive activation of NF-&kgr;B is implicated.
    Type: Application
    Filed: April 2, 2004
    Publication date: September 30, 2004
    Inventors: Zehong Wan, Joelle L. Burgess, James F. Callahan
  • Publication number: 20040192741
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Application
    Filed: January 21, 2004
    Publication date: September 30, 2004
    Applicant: SmithKline Beecham Corporation & NPS Pharmaceuticals
    Inventors: Maria Amparo Lago, James Francis Callahan, Pradip Kumar Bhatnagar, Eric G. Del Mar, William M. Bryan, Joelle L. Burgess
  • Publication number: 20040039198
    Abstract: This invention relates to 2-pyridyl substituted diarylimidazoles which are inhibitors of the transforming growth factor, (“TGF”)-&bgr; signaling pathway, in particular, the phosphorylation of smad2 or smad3 by the type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine.
    Type: Application
    Filed: May 14, 2003
    Publication date: February 26, 2004
    Inventors: Paul E. Bender, Joelle L. Burgess, James F. Callahan
  • Publication number: 20040009980
    Abstract: Novel phosphate esters compounds and methods of using them as calcilytic compounds are provided.
    Type: Application
    Filed: April 24, 2003
    Publication date: January 15, 2004
    Inventors: Pradip Bhatnagar, Joelle L. Burgess, James F. Callahan, Maria A. Lago
  • Publication number: 20030018203
    Abstract: Novel calcilytic compounds and methods of using them are provided.
    Type: Application
    Filed: July 17, 2002
    Publication date: January 23, 2003
    Inventors: Maria Amparo Largo, James Francis Callahan, Pradip Kumar Bhatnagar, Eric G. Del Mar, William M. Bryan, Joelle L. Burgess
  • Patent number: 6465493
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1, R2 and R3 are various substituent groups; and one of X1 and X2 is N or CR′, and the other is NR′ or CHR′ wherein R′ is hydrogen, OH, C1-6alkyl, or C3-7cycloalkyl; or when one of X1 and X2 is N or CR′ then the other may be S or O; and their use as pharmaceuticals.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: October 15, 2002
    Assignee: Smithkline Beecham Corporation
    Inventors: Joelle L. Burgess, James F. Callahan