Patents by Inventor Johannes Clevers

Johannes Clevers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of an Intestinal Adenoma and/or Adenocarcinoma by Inhibition of Notch Pathway Activation
    Publication number: 20070265246
    Abstract: The invention relates to the field of biochemistry and medicine. More specifically the invention relates to methods and pharmaceuticals for the treatment of intestinal neoplasia. The invention discloses the surprising finding that inhibitors of Notch pathway activation (for example ?-secretase inhibitors) are extremely useful in the treatment of intestinal adenoma and/or adenocarcinoma.
    Type: Application
    Filed: November 10, 2005
    Publication date: November 15, 2007
    Inventors: Johannes Clevers, Maria Van Gijn, Johannes Van Es
  • Use of specified tcf target genes to identify drugs for the treatment of cancer in particular colorectal cancer in which tcf/ss-cateini/wnt signalling plays a central role
    Publication number: 20060165699
    Abstract: The present invention relates to the use of inhibitors of the expressed proteins of TCF target genes whose expression is regulated by TCF/?-catenin complexes for the preparation of a therapeutical composition for the treatment of cancers in which TCF/?-catenin signalling is deregulated. Such inhibitors can be antibodies, small molecules, antisense RNA and dsRNA for use in RNAi. The invention also relates to these inhibitors per se.
    Type: Application
    Filed: July 8, 2003
    Publication date: July 27, 2006
    Inventors: Frederic Colland, Nicholas Barker, Johannes Clevers, Eduard Gomez, Marcus Lambertus, Elena Suils