Abstract: The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid molecules. A modular design principle is provided that is suitable to generate a nucleic acid, particularly mRNA, which is tailored for a respective application. The nucleic acid molecules of the present invention can be obtained by the versatile combination of multiple modules on nucleic acid level. Such nucleic acid, e.g. mRNA, can be tailored by combining one or more modules, comprising (i) a nucleic acid moiety encoding a polypeptide of interest (e.g. a protein potentially producing a therapeutic outcome) and (ii) at least one further coding or non-coding nucleic acid moiety, e.g.

Abstract: A method for collecting telemetry data for updating a 3D map of an environment comprising carrying out a first relocalization event whereby: data from an observation at time t1 by a pose tracker is used to compute a first 3D map pose of the pose tracker, and a first local pose of the pose tracker at time t1 is received. A second relocalization event occurs where a second 3D map pose of the pose tracker is computed from data from an observation at time and a second local pose of the pose tracker at time t2 is received. A first relative pose between the first and second 3D map pose is computed. A second relative pose between the first and second local pose is computed. A residual being a difference between the first relative pose and the second relative pose is stored as input to a process for updating the 3D map.

Abstract: A 3D map comprising sensor data items depicting the environment is updated, each sensor data item having one or more associated variables such as a pose of a capture device or a position of a landmark. A graph is calculated from sensor data items. The graph comprises nodes and edges, a node representing at least one variable in the received sensor data items and an edge representing relationships between variables. The graph is partitioned into a plurality of subgraphs so as to reduce a number of variables that are shared between subgraphs. Each of the plurality of subgraphs is allocated to a respective worker node. At each worker node, updated values of the variables are computed. The process updates values of variables which are shared between subgraphs to a common value using a consensus process. The 3D map of the environment is updated according to the updated values of the variables.

Abstract: A method for authorizing access to one or more secured computer resources includes obfuscating a reference biometric vector into an obfuscated reference biometric vector using a similarity-preserving obfuscation. An authentication biometric vector is obfuscated into an obfuscated authentication biometric vector using the similarity-preserving obfuscation. A similarity of the obfuscated authentication biometric vector and the obfuscated reference biometric vector is tested. Based on the similarity being within an authentication threshold, access to the one or more secured computer resources is authorized.

Abstract: The invention relates inter alia to a combination comprising (i) a first component comprising at least one therapeutic RNA and (ii) a second component comprising at least one antagonist of at least one RNA sensing pattern recognition receptor. Further provided are compositions comprising at least one therapeutic RNA and at least one antagonist of at least one RNA sensing pattern recognition receptor. The combination of the two components is able to reduce immunostimulatory properties of the first component as well as promote expression after administration. Additionally, first and second medical uses, and methods of treating or preventing diseases, disorders or conditions are provided.

Abstract: The present invention is directed to an artificial nucleic acid, particularly to an artificial RNA suitable for use in treatment and/or prophylaxis of an infection with yellow fewer vims (YFV) or a disorder related to such an infection. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial RNA, compositions and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial RNA, compositions and vaccines.

Abstract: A method for image-based localization includes, at a camera device, capturing a plurality of images of a real-world environment. A first set of image features are detected in a first image of the plurality of images. Before additional sets of image features are detected in other images of the plurality, the first set of image features is transmitted to a remote device configured to estimate a pose of the camera device based on image features detected in the plurality of images. As the additional sets of image features are detected in the other images of the plurality, the additional sets of image features are transmitted to the remote device. An estimated pose of the camera device is received from the remote device.

Abstract: The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.

Abstract: The present invention is directed to an artificial nucleic acid, particularly to an artificial RNA suitable for use in treatment and/or prophylaxis of an infection with Respiratory syncytial virus (RSV) or a disorder related to such an infection. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial RNA, compositions, and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial RNA, compositions and vaccines.

Abstract: Stereo image reconstruction can be achieved by fusing a plurality of proposal cost volumes computed from a pair of stereo images, using a predictive model operating on pixelwise feature vectors that include disparity and cost values sparsely sampled form the proposal cost volumes to compute disparity estimates for the pixels within the image.

Abstract: The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid molecules. A modular design principle is provided that is suitable to generate a nucleic acid, particularly mRNA, which is tailored for a respective application. The nucleic acid molecules of the present invention can be obtained by the versatile combination of multiple modules on nucleic acid level. Such nucleic acid, e.g. mRNA, can be tailored by combining one or more modules, comprising (i) a nucleic acid moiety encoding a polypeptide of interest (e.g. a protein potentially producing a therapeutic outcome) and (ii) at least one further coding or non-coding nucleic acid moiety, e.g.

Abstract: A method for image-based localization includes, at a camera device, capturing a plurality of images of a real-world environment. A first set of image features are detected in a first image of the plurality of images. Before additional sets of image features are detected in other images of the plurality, the first set of image features is transmitted to a remote device configured to estimate a pose of the camera device based on image features detected in the plurality of images. As the additional sets of image features are detected in the other images of the plurality, the additional sets of image features are transmitted to the remote device. An estimated pose of the camera device is received from the remote device.

Abstract: The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.

Abstract: Methods, systems, and computer readable media for image overlap detection. An example method includes identifying, by one or more computers, a collection of images; streaming, by the one or more computers, each image from the collection of images so that, in one or a limited number of passes through the collection of images, each image is loaded only once from an input source and each image is discarded after a processing time for the image is exceeded; and during the streaming, for each image in at least a first subset of the images in the collection, determining whether the image overlaps with at least one other image in the at least a first subset of the images.

Abstract: Stereo image reconstruction can be achieved by fusing a plurality of proposal cost volumes computed from a pair of stereo images, using a predictive model operating on pixelwise feature vectors that include disparity and cost values sparsely sampled form the proposal cost volumes to compute disparity estimates for the pixels within the image.

Abstract: The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid molecules. A modular design principle is provided that is suitable to generate a nucleic acid, particularly mRNA, which is tailored for a respective application. The nucleic acid molecules of the present invention can be obtained by the versatile combination of multiple modules on nucleic acid level. Such nucleic acid, e.g. mRNA, can be tailored by combining one or more modules, comprising (i) a nucleic acid moiety encoding a polypeptide of interest (e.g. a protein potentially producing a therapeutic outcome) and (ii) at least one further coding or non-coding nucleic acid moiety, e.g.

Abstract: A composition or combination comprising at least a first immunogenic component and at least a second adjuvant component, wherein the first immunogenic component comprises at least one nucleic acid molecule encoding at least one epitope of at least one antigen, and wherein the second adjuvant component comprises at least one immune potentiator compound and/or at least one delivery system compound.

Abstract: Methods, systems, and computer readable media for image overlap detection. An example method includes identifying, by one or more computers, a collection of images; streaming, by the one or more computers, each image from the collection of images so that, in one or a limited number of passes through the collection of images, each image is loaded only once from an input source and each image is discarded after a processing time for the image is exceeded; and during the streaming, for each image in at least a first subset of the images in the collection, determining whether the image overlaps with at least one other image in the at least a first subset of the images.

Abstract: A system and method for monitoring third party access to a restricted item is provided. Key data is embedded in the restricted item, the key data being associated with a store of value and usable to conduct a transaction against the store of value. A record of the transaction becomes visible in a transaction ledger. The transaction ledger is monitored to determine whether a transaction against the store of value has occurred, and the restricted item is designated as accessed by a third party in the event that a transaction against the store of value has occurred.

Abstract: A system and method for monitoring third party access to a restricted item is provided. Key data is embedded in the restricted item, the key data being associated with a store of value and usable to conduct a transaction against the store of value. A record of the transaction becomes visible in a transaction ledger. The transaction ledger is monitored to determine whether a transaction against the store of value has occurred, and the restricted item is designated as accessed by a third party in the event that a transaction against the store of value has occurred.