Patents by Inventor Johannes Zuegg

Johannes Zuegg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190337880
    Abstract: Disclosed are compounds of a formula provided herein that show efficacy in the inhibition of SOX18 protein activity, and in particular with respect to the ability of SOX18 to bind DNA and/or particular protein partners. Further, methods of treating angiogenesis- and/or lymphangiogenesis-related diseases, disorders or conditions, such as cancer metastasis and vascular cancers, are provided herein.
    Type: Application
    Filed: December 21, 2017
    Publication date: November 7, 2019
    Inventors: Mathias FRANCOIS, Johannes ZUEGG, Jeroen OVERMAN, Sreeman Kumar MAMIDYALA, Angela Aguslyarti SALIM, Frank Roger FONTAINE, Matthew Allister COOPER, Robert John CAPON, Avril Alexis Barbara ROBERTSON
  • Patent number: 9709571
    Abstract: The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: July 18, 2017
    Assignee: VAST BIOSCIENCE PTY LIMITED
    Inventors: Gerald B. Tometzki, Wim F. Meutermans, Johannes Zuegg
  • Patent number: 8426345
    Abstract: The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
    Type: Grant
    Filed: October 3, 2006
    Date of Patent: April 23, 2013
    Assignee: Alchemia Limited
    Inventors: Wim Meutermans, Johannes Zuegg, Michael L. West
  • Patent number: 7994140
    Abstract: The present invention relates to a method of identifying a candidate therapeutic agent. The method comprises contacting a G-Protein Coupled Receptor (GPCR) with a compound of General Formula (I), or a pharmaceutically acceptable salt thereof determining whether the compound inhibits or effects signal transduction activity of the GPCR, wherein a compound that inhibits or effects the activity of the GPCR is a candidate therapeutic agent.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: August 9, 2011
    Assignee: Alchemia Limited
    Inventors: Wim Meutermans, Glang Le Thanh, Giovanni Abbenante, Gerald Tometzki, Judy Halliday, Johannes Zuegg
  • Patent number: 7989422
    Abstract: The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein:
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: August 2, 2011
    Assignee: Alchemia Limited
    Inventors: Wim Meutermans, Declan McKeveney, Johannes Zuegg, Rajaratnam Premraj, Craig Muldoon, Giang Thanh Le
  • Publication number: 20090163373
    Abstract: The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).
    Type: Application
    Filed: October 3, 2006
    Publication date: June 25, 2009
    Applicant: Alchemia Limited
    Inventors: Gerald B. Tometzki, Michael L. West, Wim Meutermans, Johannes Zuegg
  • Publication number: 20090023669
    Abstract: The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein:
    Type: Application
    Filed: December 20, 2006
    Publication date: January 22, 2009
    Applicant: Alchemia Limited
    Inventors: Wim Meutermans, Declan McKeveney, Johannes Zuegg, Rajaratnam Premraj, Craig Muldoon, Giang Thanh Le
  • Publication number: 20080280837
    Abstract: A method for inhibiting angiogenesis in a subject comprising administering to the subject at least one compound of General Formula (I), wherein the ring or any chiral center(s) may be of any configuration; Z is sulphur, oxygen, CH2, C(O), C(O)HN, NH, NRA or hydrogen, in the case where Z is hydrogen then R1 is not present, RA is selected from the set defined for R1 to R5, X and X? are independently oxygen or nitrogen providing that at least one X of General Formula (I) is nitrogen, X or X? may also combine independently with one of R1 to R5 to form an azide, R1 to R5 are independently selected from the following definition which includes but is not limited to H or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear, and R6 and R7 are hydrogen, or may combine to form a carbonyl function.
    Type: Application
    Filed: April 7, 2005
    Publication date: November 13, 2008
    Inventors: Judy Halliday, Wim Meutermans, Gerald Tometzki, Tracie E. Ramsdale, Johannes Zuegg, Bernd Becker, Craig Muldoon, Declan McKeveney, Rajaratnam Premraj, Glenn Condie
  • Publication number: 20080009418
    Abstract: A method of identifying biologically active compounds with defined selectivity profile comprises: (c) designing a library of compounds of formula (1) to scan molecular diversity; and (d) assaying the library of compounds in at least two different biological assays.
    Type: Application
    Filed: October 4, 2005
    Publication date: January 10, 2008
    Applicant: Alchemia LTD.
    Inventors: Gerald Tometzki, Wim Meutermans, Bernd Becker, Johannes Zuegg, Rajaratnam Premraj, Craig Muldoon, Declan McKeveney, Glenn Condie
  • Publication number: 20060223764
    Abstract: A method of inhibiting or effecting the activity of a GPCR which comprises contacting a GPCR with a compound of general formula 1, or a pharmaceutically acceptable salt thereof
    Type: Application
    Filed: October 10, 2003
    Publication date: October 5, 2006
    Inventors: Wim Meutermans, Glang Le Thanh, Giovanni Abbenante, Gerald Tometzki, Judy Halliday, Johannes Zuegg