Patents by Inventor John A. Beutler

John A. Beutler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SCHWEINFURTHIN ANALOGUES
    Publication number: 20080015232
    Abstract: Methods and intermediates for preparing enantiomerically enriched Schweinfurthin analogs which are useful for the treatment of cancer, as well as novel Schweinfurthin analogs having anti-cancer activity, compositions comprising such analogs and therapeutic methods comprising administering such analogs.
    Type: Application
    Filed: March 29, 2005
    Publication date: January 17, 2008
    Inventors: David F. Wiemer, Jeffrey D. Neighbors, John A. Beutler
  • Macrocyclic lactones, compositions, and methods of use
    Patent number: 6353019
    Abstract: The present invention provides compound of the formula: wherein R1 and R2 are the same or different and are independently H, C1-C6 straight-chain or branched saturated or unsaturated alkyl, aryl, R6CH2—, R6CO—, or R6SO2—, wherein R6 is H, C1-C6 straight-chain or branched saturated or unsaturated alkyl, or aryl; R3 is H, C1→C6 straight-chain or branched-chain saturated alkyl, aryl, an oxime, or an oxime methyl ether; at least one aromatic ring position is optionally substituted with a substituent selected from the group consisting of halo, nitro, amino, hydroxyl, thio, acyl, C1-C6 alkyl, and cyano; and Z is a contiguous linker comprising a chain of 7-10 atoms (including heteroatoms) which atoms, together with the five atoms beginning with the carbon of the aromatic ring in meta-relationship with OR1 and ending with the carbon directly attached to the alkyl oxygen of the lactone, which carbons are covalently bonded to either end of linker Z, integrally form a 12-15 membe
    Type: Grant
    Filed: April 10, 2000
    Date of Patent: March 5, 2002
    Assignee: United States of America as represented by the Department of Health and Human Services
    Inventors: Michael R. Boyd, Tawnya C. McKee, John H. Cardellina, II, John A. Beutler, Karen Erickson, Deborah Galinis, Lewis Pannell
  • Antiviral composition
    Patent number: 5599839
    Abstract: The present invention relates to an antiviral composition and to methods of treating patients with viral infections. The antiviral composition of the present invention comprises prostratin, a phorbol ester derivative, and a pharmaceutically acceptable carrier. The present composition while having antiviral activity does not have substantial tumor promoting activity and does not have other substantial adverse toxicological properties that would preclude its use in antiviral therapy.
    Type: Grant
    Filed: April 17, 1995
    Date of Patent: February 4, 1997
    Assignees: The United States of America as represented by the Department of Health and Human Services, Brigham Young University
    Inventors: Michael R. Boyd, Paul A. Cox, Gordon M. Cragg, Peter M. Blumberg, Nancy A. Sharkey, Junichi Ishitoya, James B. McMahon, John A. Beutler, Owen S. Weislow, John H. Cardellina, II, Krik R. Gustafson
  • Antitumor antibiotic
    Patent number: 5086045
    Abstract: An antitumor antibiotic designated BMY-41339 is produced by fermentation of certain strains of Actinomadura verrucosospora. BMY-41339 exhibits antimicrobial activity and also inhibits the growth of tumors in experimental animals.
    Type: Grant
    Filed: August 24, 1990
    Date of Patent: February 4, 1992
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jerzy Golik, John Beutler, Pat Clark, John Ross, John Roach, Gary Muschik, William B. Lebherz, III
  • Antitumor antibiotic BMY-41339
    Patent number: 5028536
    Abstract: An antitumor antibiotic designated BMY-41339 is produced by fermentation of certain strains of Actinomadura verrucosospora. BMY-41339 exhibits antimicrobial activity and also inhibits the growth of tumors in experimental animals.
    Type: Grant
    Filed: March 15, 1989
    Date of Patent: July 2, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jerzy Golik, John Beutler, Pat Clark, John Ross, John Roach, Gary Muschik, William B. Lebherz, III