Abstract: Methods of characterizing an analyte using a nanopore. One aspect features methods for characterizing a double-stranded polynucleotide using a nanopore, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.

Abstract: A method and system for installing Stockbridge dampers on wires, such as power lines and guy wires, is described. The method and system include the use of a robotic Stockbridge damper installer onto the wires where the robotic installer is configured to place Stockbridge dampers on the wire as the robotic installer travels along the wire.

Abstract: A rotor system for aerial vehicles where two or more rotor systems are used in a coaxial or tandem arrangement on the aerial vehicle.

Abstract: Methods, systems, and devices for wireless communications are described. A base station may implement cross-carrier scheduling. A user equipment (UE) may identify a minimum scheduling delay and may receive a downlink grant on a first CC. The UE may further identify the slot in which a downlink data transmission corresponding to the downlink grant will be received, and may identify the slot such that the minimum scheduling delay is satisfied. The UE may the receive the downlink data transmission, as indicated in the downlink grant, in the identified slot. In some examples, the UE and the base station may alternate between a long minimum scheduling delay and a short minimum scheduling delay. In some examples, the UE and the base station may alternate between a cross-carrier mode, and a self-scheduling mode.

Abstract: Provided herein is a method of concentrating a tethering complex in a region of an amphiphilic layer, such as a lipid membrane. Also provided herein are methods of assembling a tethering complex; methods of concentrating an analyte in the region of a detector; amphiphilic layers; and arrays and devices for use in the disclosed methods.

Abstract: Certain exemplary embodiments can provide a method that can include: sending software to a first information device and to a second information device, the software adapted to enable the user of the first information device to create a request that content be created by the user of the second information device; providing the content of that request to the software running on the second information device, the software adapted to cause the content of the request to be rendered via the second information device; the software further adapted to enable the user of the second information device to create a response to the request; and providing the content of that response to the software running on the first information device, the software adapted to cause the content of the response to be rendered via the first information device.

Abstract: The invention relates to new methods of moving helicases past spacers on polynucleotides and controlling the loading of helicases on polynucleotides. The invention also relates to new methods of characterising target polynucleotides using helicases.

Abstract: An electronic device includes an enclosure formed of a plurality of layers cooperating to define an interior volume. The enclosure includes a first layer formed of a first material and defining a user input surface of the enclosure and a first portion of a side surface of the enclosure. The enclosure also includes a second layer, formed of a second material different from the first material, positioned below the first layer and defining a second portion of the side surface of the enclosure. The enclosure also includes a third layer, formed of a third material different from the first and second materials, positioned below the second layer and defining a bottom surface of the enclosure and a third portion of the side surface of the enclosure.

Abstract: A negative hinge offset rotor head for a coaxial helicopter, the rotor head having two or more flapping rotor blades having outer and inner tips, the inner tips rotatably attached to a hinge attachment rotated by a driveshaft where the driveshaft is positioned between the rotor blades and the rotor blades' respective hinge attachment.

Abstract: Droplet interfaces are formed between droplets in an electro-wetting device comprising an array of actuation electrodes. Actuation signals are applied to selected actuation electrodes to place the droplets into an energised state in which the shape of the droplets is modified compared to a shape of the droplets in a lower energy state and to bring the two droplets into proximity. The actuation signals are then changed to lower the energy of the droplets into the lower energy state so that the droplets relax into the gap and the two droplets contact each other thereby forming a droplet interface. The use of sensing electrodes in the device permit electrical current measurements across the droplet interface. The sensing electrodes can be used for either (i) applying a reference signal during droplet actuation or (ii) recording electrical current measurements.

Abstract: An injection device is described. The injection device includes a stopper having a first conductive element, a barrel having a medicament reservoir sealed at a proximal end with the stopper, and a plunger rod having a second conductive element. The plunger rod is coupled with the stopper to cause forward axial movement of the stopper to expel a medicament from the medicament reservoir. The first conductive element and the second conductive element complete an electrical circuit when the plunger rod is coupled to the stopper.

Abstract: Injection monitoring circuitry is provided for coupling to part of an injection device having a syringe and a plunger rod. The injection monitoring circuitry has an input to receive force measurement data from a force sensor, the force measurement data includes a plurality of timestamped force measurements of force applied by a user to the injection device when an injection is administered to an injection site. Processing circuitry is provided to determine from the force measurement data when an end of injection has been reached, the end of injection corresponding to the plunger rod having reached an end position in a distal portion of the barrel of the syringe during administration of the injection by the user. Machine readable instructions and an injection monitoring method are also provided.

Abstract: A dry powder inhaler is provided. The inhaler is adapted for detachably mounting a compliance monitor having a pressure sensor. The inhaler has a housing comprising first and second shell parts, and a mouthpiece which defines an inhalation passage. An external surface of the housing has an orifice. A conduit from the orifice to the inhalation passage is formed by a channel in one of the shell parts and a corresponding channel cover in the other shell part. When the compliance monitor is mounted on the housing, the pressure sensor is adjacent to the orifice and is in fluid communication with the inhalation passage via the conduit.

Abstract: A wheel immobilizer has a plurality of C-shaped members extendable about the wheel, including a telescopic member that is lockable in place. A unit connector and a wheel fastener cover are shaped to extend about fasteners of the wheel. The unit connector includes a threaded member and is shaped to enable macro and micro adjustments of the extent to which the wheel fastener cover extends from the C-shaped members. Slots of the unit connector enable the wheel immobilizer to couple together within a plane in a storage position. Projections of the wheel immobilizer inhibit rotation of the wheel and are tuned to make a noise when rotation of the wheel is attempted. An elongate round member is positioned within the telescopic member and configured to inhibit cutting therethrough. C-shaped members are rotatably coupled together via detent mechanisms the tension of which is adjusted via set screws which are externally accessible.

Abstract: A dry powder inhaler and an adherence and/or compliance monitor for use with the inhaler are provided. The inhaler has a cover which is pivotable relative to its housing in order to expose a mouthpiece. The monitor has one or more sensors. The inhaler and the monitor have formations for mounting the monitor onto the inhaler. The inhaler and monitor are designed so that when the monitor is mounted onto the housing of the inhaler and the cover is opened, the cover at least partially covers and protects the monitor.

Abstract: Methods and systems are described for a media guidance application that enhances the viewing experiences of users consuming a sequence of media. In particular, the media guidance application may enhance the viewing experiences of users consuming a sequence of media by removing portions of redundant media that were previously consumed by the user.

Abstract: The disclosure provides a method of improving the cognitive function of an animal by providing a composition containing beta-casein, wherein at least 75% by weight of the beta-casein is a beta-casein variant that does not produce BCM-7 on digestion in the gut of the animal.

Abstract: A water use management system may be installed in a setting that contains a primary infrastructure for water use to provide an alternate, modular infrastructure for water use. Fresh water used at various points of use, such as a shower or sink, may be diverted into the modular infrastructure prior to draining into the primary infrastructure. Once diverted, the precedent use water is received at a reservoir system where it is treated for a subsequent use. Treatment may include filtration and/or chemical treatment, and may be based upon sensor feedback from the reservoir system. Once treated, the water is ready for subsequent use and may flow from the reservoir system, via the modular infrastructure, to a subsequent point of use, such as a toilet.

Abstract: A water use management system may be installed in a setting that contains a primary infrastructure for water use to provide an alternate, modular infrastructure for water use. Fresh water used at various points of use, such as a shower or sink, may be modified by a point of use water conditioner. Water may be modified at the point of use based upon pre-configured routines or manual user selections. Treatments performed on the water may include quality treatments, such as modifying the pH or mineral content, and may also include experience treatments, such as the addition of scents, colors, carbonation, or health and beauty supplements. Additives used during treatment are provided in cartridges that may be inserted and removed from the water conditioner. Cartridges may self-identify when inserted, to aid in compatibility and usability determinations and recycling/recertification processes.

Abstract: A water use management system may be installed in a setting that contains a primary infrastructure for water use to provide an alternate, modular infrastructure for water use. Fresh water used at various points of use, such as a shower or sink, may be modified by a point of use water conditioner. Water may be modified at the point of use based upon pre-configured routines or manual user selections. Treatments performed on the water may include quality treatments, such as modifying the pH or mineral content, and may also include experience treatments, such as the addition of scents, colors, carbonation, or health and beauty supplements. Additives used during treatment are provided in cartridges that may be inserted and removed from the water conditioner. Cartridges may self-identify when inserted, to aid in compatibility and usability determinations and recycling/recertification processes.