Abstract: The instant disclosure provides novel adenosine receptor antagonist compounds, compositions, methods of making and methods of using. In a further aspect, a method of treating a subject in need thereof, comprising administering a therapeutically effective amount of any one or more of the compounds described herein. In some embodiments, the subject has cancer and the method is a method of treating cancer.

Abstract: Systems and methods are disclosed for an electrical sensing, pacing, and ablation device comprising a bendable and stretchable balloon catheter and a bendable and stretchable first layer connected to or embedded in said balloon catheter, where the first layer has an electrode array with a plurality of electrodes. The is also a bendable and stretchable second layer connected to or embedded in the balloon catheter, and the second layer has a pressure sensor array with a plurality of pressure sensors.

Abstract: Systems and techniques that provide improvements to designer applications as described to address, for example, limitations associated with constructing a user interface as it is being designed by a user in a development environment. In some implementations, a system provides a design interface through which a user can view, develop, and test functional aspects of an electronic form in real-time while the user is building the application. The system maintains associations between components of the electronic form and expressions for the components referenced in program logic for the electronic form.

Abstract: Provided are tissue-mounted devices and methods for monitoring a thermal transport property (e.g., thermal conductivity, thermal diffusivity, heat capacity) of tissue, such as skin. The devices conformally mount to the tissue and have one or more thermal actuators and a plurality of sensors. The actuator applies heat to the tissue and the sensors to detect a spatio temporal distribution of a physiological tissue parameter or physical property resulting from the heating. This spatio temporal information may be correlated with a rate, velocity and/or direction of blood flow, the presence of a vascular occlusion, circulation changes due to inflammation, hydration level and other physiological parameters.

Abstract: In some implementations, a system enables users to create dynamically configurable applications that can be dynamically configured and adjusted. An application that runs on the server system in a first configuration is configured using a first configuration template. Data indicating (i) that the application is being accessed on a computing device in the first configuration, and (ii) a request to adjust the first configuration of the application is received. Operations are then performed while the application is being accessed on the computing device in the first configuration. A second configuration template that specifies a second configuration of the application corresponding to the request included in the received data is generated. The application is adjusted using the second configuration template to run in the second configuration. An instruction is provided to the computing device to enable the computing device to access the application running in the second configuration.

Abstract: Provided are optical devices and systems fabricated, at least in part, via printing-based assembly and integration of device components. In specific embodiments the present invention provides light emitting systems, light collecting systems, light sensing systems and photovoltaic systems comprising printable semiconductor elements, including large area, high performance macroelectronic devices. Optical systems of the present invention comprise semiconductor elements assembled, organized and/or integrated with other device components via printing techniques that exhibit performance characteristics and functionality comparable to single crystalline semiconductor based devices fabricated using conventional high temperature processing methods. Optical systems of the present invention have device geometries and configurations, such as form factors, component densities, and component positions, accessed by printing that provide a range of useful device functionalities.

Abstract: In one embodiment, a method includes, by a computing system associated with a vehicle, receiving sensor data from one or more sensors of the vehicle, wherein the sensor data is based on an environment of the vehicle, identifying, based on the sensor data, one or more objects in the environment, generating, based on the one or more objects, a set of points that represent the environment, wherein each object has one or more corresponding points in the set of points, and each of the points is associated with one or more features associated with the corresponding object, generating a prediction for at least one of the objects in the environment or the vehicle by processing the set of points using a machine-learning model, and causing the vehicle to perform one or more operations based on the prediction.

Abstract: A reusable, protective face mask has two detachable filter trays that attach on each side of the mask, a soft elastomeric face seal, and straps to go around the user's head. Exhalations and inhalations can pass through the same filter material. The filter trays can accept arbitrary filter media. A forward-facing port can be used to increase speech intelligibility by transmitting sound through a diaphragm without a prohibitive amount of distortion. Manufacture of the mask is facilitated because the mask body and the other mask components can be produced by injection molding. Decontamination and sterilization are facilitated because the mask can be fully disassembled.

Abstract: A method of controlling an operating temperature of a first combustion zone of a combustor of a rotary machine includes determining a current operating temperature and a target operating temperature of a first combustion zone using a digital simulation. The method further includes determining a derivative of the current operating temperature with respect to a current fuel split using the digital simulation. The fuel split apportions a total flow of fuel to the combustor between the first combustion zone and a second combustion zone. The method also includes calculating a calculated fuel split that results in a calculated operating temperature approaching the target operating temperature. The method further includes channeling a first flow of fuel to the first combustion zone and a second flow of fuel to the second combustion zone.

Abstract: A system and method to join distributed energy resources (DER) to achieve common objectives is provided. The present technology organizes and/or aggregates DERs by routing a (DER) program request for resources to DER contributors capable of responding to and performing the request using a routing system. The system accesses a plurality of DER profiles, each profile associated with a DER contributor capable of contributing a resource to the request, and calculates an initial value for each DER profile based on request attributes and scoring metrics associated with the profile. The system then calculates a fitness metric for each DER profile based on the initial value using a neural network having weights based on the plurality of performance indicators and selects the DER profile and contributors to whom to route the request.

Abstract: A mobile communication device-based corneal topography system includes an illumination system, an imaging system, a topography processor, an image sensor, and a mobile communication device. The illumination system is configured to generate an illumination pattern reflected off a cornea of a subject. The imaging system is coupled to an image sensor to capture an image of the reflected illumination pattern. A topography processor is coupled to the image sensor to process the image of the reflected illumination pattern. The mobile communications device includes a display, the mobile communications device is operatively coupled to the image sensor. The mobile communications device includes a mobile communications device (MCD) processor. A housing at least partially encloses one or more of the illumination system, the imaging system, or the topography processor.

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

Abstract: A mobile communication device-based corneal topography system includes an illumination system, an imaging system, a topography processor, an image sensor, and a mobile communication device. The illumination system is configured to generate an illumination pattern reflected off a cornea of a subject. The imaging system is coupled to an image sensor to capture an image of the reflected illumination pattern. A topography processor is coupled to the image sensor to process the image of the reflected illumination pattern. The mobile communications device includes a display, the mobile communications device is operatively coupled to the image sensor. The mobile communications device includes a mobile communications device (MCD) processor. A housing at least partially encloses one or more of the illumination system, the imaging system, or the topography processor.

Abstract: Packages made from flexible material, wherein the packages include one or more self-folds formed by applying activation energy to the flexible material are presented. The packages include a polymeric film, wherein the polymeric film is formed from one type of polymer, and wherein the flexible material defines an enclosed product volume. The packages include a first panel formed from the flexible material and a second panel formed from the flexible material. The packages include a self-fold that has an overall thickness that is about 5% to about 30% greater than a thickness of the flexible material outside of the self-fold. The self-fold has a differential thermal-mechanical set than the flexible material outside of the self-fold, and forms an angle of about 100 degrees to about 170 degrees between the first panel and the second panel.

Abstract: Provided are optical devices and systems fabricated, at least in part, via printing-based assembly and integration of device components. In specific embodiments the present invention provides light emitting systems, light collecting systems, light sensing systems and photovoltaic systems comprising printable semiconductor elements, including large area, high performance macroelectronic devices. Optical systems of the present invention comprise semiconductor elements assembled, organized and/or integrated with other device components via printing techniques that exhibit performance characteristics and functionality comparable to single crystalline semiconductor based devices fabricated using conventional high temperature processing methods. Optical systems of the present invention have device geometries and configurations, such as form factors, component densities, and component positions, accessed by printing that provide a range of useful device functionalities.

Abstract: The provided systems, methods and devices describe lightweight, wireless tissue monitoring devices that are capable of establishing conformal contact due to the flexibility or bendability of the device. The described systems and devices are useful, for example, for skin-mounted intraoperative monitoring of nerve-muscle activity. The present systems and methods are versatile and may be used for a variety of tissues (e.g. skin, organs, muscles, nerves, etc.) to measure a variety of different parameters (e.g. electric signals, electric potentials, electromyography, movement, vibration, acoustic signals, response to various stimuli, etc.).

Abstract: Systems and techniques that provide improvements to designer applications as described to address, for example, limitations associated with constructing a user interface as it is being designed by a user in a development environment. In some implementations, a system provides a design interface through which a user can view, develop, and test functional aspects of an electronic form in real-time while the user is building the application. The system maintains associations between components of the electronic form and expressions for the components referenced in program logic for the electronic form.

Abstract: A system and method to join distributed energy resources (DER) to achieve common objectives is provided. The present technology organizes and/or aggregates DERs by routing a (DER) program request for resources to DER contributors capable of responding to and performing the request using a routing system. The system accesses a plurality of DER profiles, each profile associated with a DER contributor capable of contributing a resource to the request, and calculates an initial value for each DER profile based on request attributes and scoring metrics associated with the profile. The system then calculates a fitness metric for each DER profile based on the initial value using a neural network having weights based on the plurality of performance indicators and selects the DER profile and contributors to whom to route the request.

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.