Abstract: Packages made from flexible material, wherein the packages include one or more self-folds formed by applying activation energy to the flexible material are presented. The packages include a polymeric film, wherein the polymeric film is formed from one type of polymer, and wherein the flexible material defines an enclosed product volume. The packages include a first panel formed from the flexible material and a second panel formed from the flexible material. The packages include a self-fold that has an overall thickness that is about 5% to about 30% greater than a thickness of the flexible material outside of the self-fold. The self-fold has a differential thermal-mechanical set than the flexible material outside of the self-fold, and forms an angle of about 100 degrees to about 170 degrees between the first panel and the second panel.

Abstract: Provided herein are medical devices comprising a plurality of biologically interactive devices configured for interacting with a large area biological surface. The biologically interactive devices each may comprise a sensor for measuring a physiological parameter. A wireless controller is configured to wirelessly operate the plurality of biologically interactive devices. A wireless transmitter is configured for wirelessly communicating an output from said plurality of biologically interactive devices to a remote receiver. The medical devices are particularly suited for measuring one or both of pressure and temperature, with compatibility for incorporating additional sensors of interest.

Abstract: Provided herein are medical sensors and related methods for measuring a real-time personal metric. The medical device may comprise an electronic device having a sensor comprising an accelerometer and a bidirectional wireless communication system electronically connected to the electronic device for sending an output signal from the sensor to an external device and receiving commands from an external controller to the electronic device.

Abstract: Methods of making packages from flexible material, wherein the packages include one or more self-folds formed by applying activation energy to the flexible material.

Abstract: Provided herein are epidermal microfluidic systems and methods that allow for the collection of biofluids in a wet or aquatic environment, for example, from the surface of the skin. The described systems allow for the efficient collection of biofluids, without loss of the biofluid to the surrounding environment or introduction of extraneous liquids from the environment. The described microfluidic systems are versatile and can provide information regarding a number of biofluid properties both electronically and colorimetrically/visually.

Abstract: In certain implementations, a user request to add a new concept may be received. A set of media item recommendations may be caused to be loaded on a user interface for presentation to a user responsive to the user request to add the new concept. The media item recommendation set may include a set of recommendations loaded on an on-screen portion of the user interface and a set of recommendations loaded on an off-screen portion of the user interface. The on-screen user interface portion is visible to the user at a first time. The off-screen user interface portion is not being visible to the user at the first time. A user selection of one or more recommendations of the on-screen recommendation set is received. The off-screen recommendation set may be caused to be updated on the user interface during the presentation of the media item recommendation set based on the user recommendation selection.

Abstract: In some embodiments, a given client computing platform may include a client-side machine learning model configured to facilitate deep neural network operations on structured data. The operations may be performed by a client application installed on the given client computing platform. The client application may locally access the client-side machine learning model in order to perform the operations. Deep neural network operations on structured data may be performed at one or more servers. Sharing of model states may be facilitated between the cloud machine learning model and the client-side machine learning model. The cloud machine learning model may be improved, at one or more servers, based on usage of the application and user interactions with the given client computing platform.

Abstract: Provided herein are smart functional fabrics and therapeutic/diagnostic garments which utilize flexible wireless electronic devices to enhance functionality, for example, by measuring key therapy parameters and providing data to clinicians, and methods utilizing such devices. The provided methods are designed to avoid patient discomfort and decrease harm or irritation caused by garments which utilize bulkier, more rigid sensors. Additionally, the described devices are multiplexed to allow for sensing of multiple parameters of therapeutic interest and combinations of measured data for new clinical metrics.

Abstract: Provided are microfluidic systems for monitoring a biofluid property and related methods. Specially configured microfluidic networks and associated structural support and functional elements, including flexible substrates, capping layers, and fluidic conduits and controllers, provide reliable biofluid collection. Optical components and indicators provide a reliable and readily observable readout, including of any of a number of biofluid properties, including directly from biofluid collected in the microfluidic network.

Abstract: Provided are implantable and bioresorbable medical devices comprising a bioresorbable substrate and an electronic circuit supported by the bioresorbable substrate. The electronic circuit comprises a membrane of silicon having a thickness less than or equal to 5 ?m and an array of dissolvable electrodes, wherein the dissolvable electrodes are formed from the membrane of silicon. The electronic circuit is configured to conformally contact a biological tissue and electrically interface with biological tissue during use. The silicon may be highly doped to provide the requisite characteristics for electrically interfacing with biological tissue, and may be further used to form other components of the electronic circuit, including back-plane transistors electrically connected to the electrode array.

Abstract: Packages made from flexible material, wherein the packages include one or more self-folds formed by applying activation energy to the flexible material.

Abstract: Provided herein are biomedical devices and methods of making and using biomedical devices for sensing and actuation applications. For example, flexible and/or stretchable biomedical devices are provided including electronic devices useful for establishing in situ conformal contact with a tissue in a biological environment. The invention includes implantable electronic devices and devices administered to the surfaces(s) of a target tissue, for example, for obtaining electrophysiology data from a tissue such as cardiac, brain tissue or skin.

Abstract: This disclosure relates to the field of mass spectrometry analysis. In some embodiments, the disclosure relates to methods for detecting and quantifying proteins by enrichment followed by mass spectrometry analysis.

Abstract: Provided are conformable devices to measure subdermal fluid flow and related methods. A soft, stretchable and flexible substrate supports a thermal actuator and various specially positioned temperature sensors. A microprocessor in electronic communication with sensors calculates subdermal fluid flow from the measured upstream and downstream temperatures, as well as various application-dependent parameters. Devices and methods provided herein are particularly useful for measuring cerebral spinal fluid in a ventricular shunt placed for treatment of hydrocephalus.

Abstract: Provided are wireless electronic devices for thermally interfacing with a biological tissue. The device may have a flexible substrate; a thermal actuator supported by said flexible substrate configured to provide a thermal input to said biological tissue; a temperature sensor supported by said flexible substrate configured to measure a temperature to determine thermal conductivity of said biological tissue; and a wireless electronic system in electronic communication with said thermal actuator and said temperature sensor, wherein said wireless electronic system is configured to provide two-way communication with an external controller. Also provided are related methods of using the electronic devices, including for cosmetic, beauty, or medical applications.

Abstract: The invention provides systems and methods for tissue-mounted photonics. Devices of some embodiments implement photonic sensing and actuation in flexible and/stretchable device architectures compatible with achieving long term, mechanically robust conformal integration with a range of tissue classes, including in vivo biometric sensing for internal and external tissues. Tissue-mounted photonic systems of some embodiments include colorimetric, fluorometric and/or spectroscopic photonics sensors provided in pixelated array formats on soft, elastomeric substrates to achieve spatially and/or or temporally resolved sensing of tissue and/or environmental properties, while minimize adverse physical effects to the tissue. Tissue-mounted photonic systems of some embodiments enable flexible passive or active optical sensing modalities, including sensing compatible with optical readout using a mobile electronic devices such as a mobile phone or tablet computer.

Abstract: A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.

Abstract: The provided systems, methods and devices describe lightweight, wireless tissue monitoring devices that are capable of establishing conformal contact due to the flexibility or bendability of the device. The described systems and devices are useful, for example, for skin-mounted intraoperative monitoring of nerve-muscle activity. The present systems and methods are versatile and may be used for a variety of tissues (e.g. skin, organs, muscles, nerves, etc.) to measure a variety of different parameterps (e.g. electric signals, electric potentials, electromyography, movement, vibration, acoustic signals, response to various stimuli, etc.).

Abstract: Off-line deep neural network operations on client computing platforms may be enabled by cooperative machine learning across multiple client computing platforms and the cloud. A given client computing platform may include a client-side machine learning model configured to facilitate deep neural network operations on structured data. The operations may be performed by a client application installed on the given client computing platform. The client application may locally access the client-side machine learning model in order to perform the operations. Deep neural network operations on structured data may be performed at one or more servers. Sharing of model states may be facilitated between the cloud machine learning model and the client-side machine learning model. The cloud machine learning model may be improved, at one or more servers, based on usage of the application and user interactions with the given client computing platform.

Abstract: In certain implementations, a user request to add a new concept may be received. A set of media item recommendations may be caused to be loaded on a user interface for presentation to a user responsive to the user request to add the new concept. The media item recommendation set may include a set of recommendations loaded on an on-screen portion of the user interface and a set of recommendations loaded on an off-screen portion of the user interface. The on-screen user interface portion is visible to the user at a first time. The off-screen user interface portion is not being visible to the user at the first time. A user selection of one or more recommendations of the on-screen recommendation set is received. The off-screen recommendation set may be caused to be updated on the user interface during the presentation of the media item recommendation set based on the user recommendation selection.