Patents by Inventor John B. Cline
John B. Cline has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230172805Abstract: A bottle for storing solid pharmaceutical products includes a substantially cylindrical body having a sidewall, a top and a base defining an interior chamber, a first opening disposed on the top of the body, the first opening providing communication to the interior chamber and being eccentric with respect to the central longitudinal axis of the body, and a second opening disposed adjacent the first opening, the second opening being smaller than the first opening.Type: ApplicationFiled: March 25, 2021Publication date: June 8, 2023Applicant: MERCK SHARP & DOHME LLCInventors: Wail A. RASHEED, Cassie R. MEGNA, Ophelia L. WELLS, John B. CLINE
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Publication number: 20230114337Abstract: A cannula for subcutaneous dispensing of medicaments, wherein the cannula has a cannula wall, a distal end and a proximal end and wherein the cannula comprises a single orifice in the cannula wall, proximal to the distal end of the cannula or two or more orifices in the cannula wall, proximal to the distal end of the cannula.Type: ApplicationFiled: February 9, 2021Publication date: April 13, 2023Applicant: Merck Sharp & Dohme LLCInventors: Scott BROWN, John B. CLINE, Michael GALLUPPI, Jeffrey C. GIVAND, Guangli HU, Steven Carl PERSAK, Wail RASHEED
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Publication number: 20230086278Abstract: The present invention provides reusable safety syringe devices for use as a teaching and practice tool. The safety syringe device of the present invention comprises four primary parts: (1) a first tubular member; (2) a second tubular member disposed within an inner annular cavity of the first tubular member; (3) a syringe secured within an inner annular cavity of the second tubular member; and (4) a plunger rod, wherein the plunger rod comprises a proximal end and a distal end, wherein the proximal end and distal end are connected by a shaft, wherein the proximal end comprises a first plunger rod flange having a first diameter and a removable second plunger rod flange having a second diameter, wherein the first diameter is smaller than the second diameter and the first plunger rod flange is located below the second plunger rod flange on the shaft.Type: ApplicationFiled: February 9, 2021Publication date: March 23, 2023Applicant: Merck Sharp & Dohme LLCInventors: John B. CLINE, Cassie MEGNA, Wail RASHEED
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Publication number: 20220387258Abstract: In one aspect of the subject invention, a labeling shell is provided for a drug vial having a glass reservoir and an opening sealed by an elastomeric stopper, the labeling shell including: a polymeric tubular body formed to accommodate the reservoir of the drug vial, the tubular body having a first open end defining a first opening smaller than a diameter of the reservoir of the drug vial so as to prevent passage therethrough of the reservoir, wherein the elastomeric stopper is exposed through the first end with the reservoir being accommodated in the tubular body; and, a polymeric cap removably mountable to the tubular body to selectively cover the elastomeric stopper of the drug vial with the reservoir being accommodated in the tubular body. Advantageously, the subject invention provides a labeling surface for a drug vial, while also providing restricted access to the drug vial to limit tampering therewith.Type: ApplicationFiled: November 10, 2020Publication date: December 8, 2022Applicant: Merck Sharp & Dohme LLCInventors: Eduardo Cristofolli, John B. Cline, Wail Rasheed, Raymond K. Seto, Steven Carl Persak, Tinh Nguyen-Demary
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Patent number: 10751493Abstract: The body has a fluid inlet port for receiving pressurized fluid and a fluid outlet port connected to the retention balloon. A first passage connects the fluid inlet port and the fluid outlet port, A second passage in the body is connected to the balloon fluid return path and is at the pressure of the retention balloon. A valve prevents fluid flow through the first passage when actuated. The valve includes a pressure-responsive member movable to a position to obstruct fluid flow in response to fluid pressure in the second passage exceeding the predetermined level. Flexible means such as a membrane defines a normally open portion of the first fluid passage, which is closed by the moveable means bearing on the membrane when pressure exceeding the predetermined level actuates the valve.Type: GrantFiled: March 2, 2017Date of Patent: August 25, 2020Assignee: CONVATEC TECHNOLOGIES INC.Inventors: Christopher Gregory, Yun Jin, John B. Cline
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Publication number: 20170173310Abstract: The body has a fluid inlet port for receiving pressurized fluid and a fluid outlet port connected to the retention balloon. A first passage connects the fluid inlet port and the fluid outlet port. A second passage in the body is connected to the balloon fluid return path and is at the pressure of the retention balloon. A valve prevents fluid flow through the first passage when actuated. The valve includes a pressure-responsive member movable to a position to obstruct fluid flow in response to fluid pressure in the second passage exceeding the predetermined level. Flexible means such as a membrane defines a normally open portion of the first fluid passage, which is closed by the moveable means bearing on the membrane when pressure exceeding the predetermined level actuates the valve.Type: ApplicationFiled: March 2, 2017Publication date: June 22, 2017Inventors: Christopher Gregory, Yun Jin, John B. Cline
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Patent number: 9623201Abstract: The body has a fluid inlet port for receiving pressurized fluid and a fluid outlet port connected to the retention balloon. A first passage connects the fluid inlet port and the fluid outlet port. A second passage in the body is connected to the balloon fluid return path and is at the pressure of the retention balloon. A valve prevents fluid flow through the first passage when actuated. The valve includes a pressure-responsive member movable to a position to obstruct fluid flow in response to fluid pressure in the second passage exceeding the predetermined level. Flexible means such as a membrane defines a normally open portion of the first fluid passage, which is closed by the moveable means bearing on the membrane when pressure exceeding the predetermined level actuates the valve.Type: GrantFiled: July 25, 2014Date of Patent: April 18, 2017Assignee: CONVATEC TECHNOLOGIES INC.Inventors: Christopher Gregory, Yun Jin, John B. Cline
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Publication number: 20150051542Abstract: The body has a fluid inlet port for receiving pressurized fluid and a fluid outlet port connected to the retention balloon. A first passage connects the fluid inlet port and the fluid outlet port. A second passage in the body is connected to the balloon fluid return path and is at the pressure of the retention balloon. A valve prevents fluid flow through the first passage when actuated. The valve includes a pressure-responsive member movable to a position to obstruct fluid flow in response to fluid pressure in the second passage exceeding the predetermined level. Flexible means such as a membrane defines a normally open portion of the first fluid passage, which is closed by the moveable means bearing on the membrane when pressure exceeding the predetermined level actuates the valve.Type: ApplicationFiled: July 25, 2014Publication date: February 19, 2015Applicant: CONVATEC TECHNOLOGIES INC.Inventors: Christopher Gregory, Yun Jin, John B. Cline
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Patent number: 8888739Abstract: The body has a fluid inlet port for receiving pressurized fluid and a fluid outlet port connected to the retention balloon. A first passage connects the fluid inlet port and the fluid outlet port. A second passage in the body is connected to the balloon fluid return path and is at the pressure of the retention balloon. A valve prevents fluid flow through the first passage when actuated. The valve includes a pressure-responsive member movable to a position to obstruct fluid flow in response to fluid pressure in the second passage exceeding the predetermined level. Flexible means such as a membrane defines a normally open portion of the first fluid passage, which is closed by the moveable means bearing on the membrane when pressure exceeding the predetermined level actuates the valve.Type: GrantFiled: November 15, 2012Date of Patent: November 18, 2014Assignee: ConvaTec Technologies, Inc.Inventors: Christopher Gregory, Yun Jin, John B. Cline
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Publication number: 20140052063Abstract: The body has a fluid inlet port for receiving pressurized fluid and a fluid outlet port connected to the retention balloon. A first passage connects the fluid inlet port and the fluid outlet port. A second passage in the body is connected to the balloon fluid return path and is at the pressure of the retention balloon. A valve prevents fluid flow through the first passage when actuated. The valve includes a pressure-responsive member movable to a position to obstruct fluid flow in response to fluid pressure in the second passage exceeding the predetermined level. Flexible means such as a membrane defines a normally open portion of the first fluid passage, which is closed by the moveable means bearing on the membrane when pressure exceeding the predetermined level actuates the valve.Type: ApplicationFiled: November 15, 2012Publication date: February 20, 2014Applicant: ConvaTec Technologies, Inc.Inventors: Christopher Gregory, Yun Jin, John B. Cline
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Patent number: 8096980Abstract: A flexible membrane is situated within a rigid or semi-rigid cap. The edge of the cap wall is adhesively fixed to the tissue surrounding the stoma. The interior of the cap is pressurized to press the membrane to seal the stoma against the discharge of solid and semi-solid waste. Gas escapes through a vent with a filter element. The cap can be pressurized by an external pump or an integral pump member situated on top of the cap. A relief valve prevents over pressurization. A collection pouch can be provided as part of a device. The device can be removably mounted on a standard two-piece faceplate.Type: GrantFiled: May 9, 2006Date of Patent: January 17, 2012Assignee: ConvaTec Technologies Inc.Inventor: John B. Cline
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Patent number: 8092437Abstract: A flexible membrane is situated within a rigid or semi-rigid cap. The edge of the cap wall is adhesively fixed to the tissue surrounding the stoma. The interior of the cap is pressurized to press the membrane to seal the stoma against the discharge of solid and semi-solid waste. Gas escapes through a vent with a filter element. The cap can be pressurized by an external pump or an integral pump member situated on top of the cap. A relief valve prevents over pressurization. A collection pouch can be provided as part of a device. The device can be removably mounted on a standard two-piece faceplate.Type: GrantFiled: March 26, 2004Date of Patent: January 10, 2012Assignee: ConvaTec Technologies Inc.Inventor: John B. Cline
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Patent number: 8070737Abstract: A controlled evacuation ostomy appliance comprises a membrane that is urged into sealing engagement with a stoma, by the generation of radial tension in the membrane. A tensioning device applies tension, with respect to the stoma, at one or more positions that are (i) outboard of the periphery of the projecting portion of the stoma, and/or (ii) between the level of the peristomal skin and the level of the most projecting part of the stoma. Tension limiting means are disclosed. The membrane may be gas-permeable to allow flatus to be vented.Type: GrantFiled: January 3, 2007Date of Patent: December 6, 2011Assignee: ConvaTec Technologies Inc.Inventors: John B. Cline, Christopher C. Gregory, Geraint Davies, Alan Cucknell, Julian Scarfe, Pete Cauwood
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Patent number: 7857796Abstract: An ostomy appliance is described in the form of a controlled discharge device for controlling discharge from the stoma and/or an ostomy pouch for collecting discharged waste. The appliance may include one or more of: an elastomeric stoma seal for providing a seal around or directly against the stoma; a stoma occluder for occluding the stoma without passing internally into the stoma; a peristomal foam wall; a confinement seal for confining at least solid excreta to a confinement region adjacent to the stoma; a stowable collector bag; and interchangeable controlled discharge devices and ostomy pouches. The foam wall may provide a barrier to stool, but allow escape of flatus. The foam wall and/or the stoma occluder and/or the confinement seal may apply a force in a direction to increase the sealing force on the stoma seal.Type: GrantFiled: January 30, 2008Date of Patent: December 28, 2010Assignee: Bristol-Myers Squibb CompanyInventors: John B. Cline, Tinh Nguyen DeMary, Andrew M. Lovatt, Philip A. Davies, Paul A. Johnson, Gary Stacey, Iain Ansell
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Patent number: 7347844Abstract: An ostomy appliance is described in the form of a controlled discharge device for controlling discharge from the stoma and/or an ostomy pouch for collecting discharged waste. The appliance may include one or more of: an elastomeric stoma seal for providing a seal around or directly against the stoma; a stoma occluder for occluding the stoma without passing internally into the stoma; a peristomal foam wall; a confinement seal for confining at least solid excreta to a confinement region adjacent to the stoma; a stowable collector bag; and interchangeable controlled discharge devices and ostomy pouches. The foam wall may provide a barrier to stool, but allow escape of flatus. The foam wall and/or the stoma occluder and/or the confinement seal may apply a force in a direction to increase the sealing force on the stoma seal.Type: GrantFiled: March 26, 2003Date of Patent: March 25, 2008Assignee: Bristol-Myers Squibb CompanyInventors: John B. Cline, Tinh Nguyen DeMary, Andrew M. Lovatt, Philip A. Davies, Paul A. Johnson, Gary Stacey, Iain Ansell
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Publication number: 20070185229Abstract: A cyanoacrylate monomer is used as an adhesion-enhancement material for enhancing at least an initial bond between a person's skin and a hydrocolloid adhesive of e.g., an ostomy or wound care appliance, for attachment to the skin. The monomer is applied to the skin in a non-activated state. Polymerization of the momoner is initiated by a material in the hydrocolloid adhesive when the adhesive appliance is pressed on the skin thereafter. The adhesion-enhancement material may further comprise a plasticizer having a low Tg (e.g., <10° C.).Type: ApplicationFiled: February 1, 2007Publication date: August 9, 2007Applicant: BRISTOL-MYERS SQUIBB COMPANYInventors: Ibraheem T. Badejo, Kenneth A. Johnsen, John B. Cline
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Publication number: 20040193122Abstract: An ostomy appliance is described in the form of a controlled discharge device for controlling discharge from the stoma and/or an ostomy pouch for collecting discharged waste. The appliance may include one or more of: an elastomeric stoma seal for providing a seal around or directly against the stoma; a stoma occluder for occluding the stoma without passing internally into the stoma; a peristomal foam wall; a confinement seal for confining at least solid excreta to a confinement region adjacent to the stoma; a stowable collector bag; and interchangeable controlled discharge devices and ostomy pouches. The foam wall may provide a barrier to stool, but allow escape of flatus. The foam wall and/or the stoma occluder and/or the confinement seal may apply a force in a direction to increase the sealing force on the stoma seal.Type: ApplicationFiled: March 26, 2003Publication date: September 30, 2004Inventors: John B. Cline, Tinh Nguyen DeMary, Andrew M. Lovatt, Philip A. Davies, Paul A. Johnson, Gary Stacey, Iain Ansell
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Publication number: 20040181197Abstract: A flexible membrane is situated within a rigid or semi-rigid cap. The edge of the cap wall is adhesively fixed to the tissue surrounding the stoma. The interior of the cap is pressurized to press the membrane to seal the stoma against the discharge of solid and semi-solid waste. Gas escapes through a vent with a filter element. The cap can be pressurized by an external pump or an integral pump member situated on top of the cap. A relief valve prevents over pressurization. A collection pouch can be provided as part of a device. The device can be removably mounted on a standard two-piece faceplate.Type: ApplicationFiled: March 26, 2004Publication date: September 16, 2004Inventor: John B. Cline
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Patent number: 6723079Abstract: A flexible membrane is situated within a rigid or semi-rigid cap. The edge of the cap wall is adhesively fixed to the tissue surrounding the stoma. The interior of the cap is pressurized to press the membrane to seal the stoma against the discharge of solid and semi-solid waste. Gas escapes through a vent with a filter element. The cap can be pressurized by an external pump or an integral pump member situated on top of the cap. A relief valve prevents over pressurization. A collection pouch can be provided as part of a device. The device can be removably mounted on a standard two-piece faceplate.Type: GrantFiled: March 27, 2002Date of Patent: April 20, 2004Assignee: Bristol-Myers Squibb CompanyInventor: John B. Cline
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Patent number: 6702794Abstract: An ostomy pouch clamp/closure and a method of production are described. The clamp comprises a blade member and a trough member hingedly coupled to the blade member and having a blade member receiving channel. At least one of the members comprises integrally molded first and second portions, being respectively a rigid portion of a first relatively hard plastics, and a soft or comfortable-feel portion of a second relatively deformable plastics. The clamp can be formed using two-shot molding. The channel also includes an elongate constriction for releasably retaining the blade member in the channel, providing a mechanical interlock along the entire length of the clamp. The clamp also includes a snap lock at its distal end.Type: GrantFiled: April 23, 2002Date of Patent: March 9, 2004Assignee: Bristol-Myers Squibb CompanyInventors: John L. Blum, John B. Cline, Kathryn A. Gargiulo