Patents by Inventor John Brian Hutchison
John Brian Hutchison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230219043Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.Type: ApplicationFiled: March 6, 2023Publication date: July 13, 2023Inventors: Darren Roy LINK, John Brian HUTCHISON, Michael L. SAMUELS, Michael WEINER
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Patent number: 11596908Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.Type: GrantFiled: August 20, 2018Date of Patent: March 7, 2023Assignee: Bio-Rad Laboratories, Inc.Inventors: Darren Roy Link, John Brian Hutchison, Michael L. Samuels, Michael Weiner
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Patent number: 11534727Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.Type: GrantFiled: October 11, 2016Date of Patent: December 27, 2022Assignee: Bio-Rad Laboratories, Inc.Inventors: Darren Link, John Brian Hutchison, Michael Samuels, Michael Weiner
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Patent number: 11511242Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.Type: GrantFiled: October 25, 2021Date of Patent: November 29, 2022Assignee: Bio-Rad Laboratories, Inc.Inventors: Darren Roy Link, John Brian Hutchison, Michael L. Samuels, Michael Weiner
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Publication number: 20220307073Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.Type: ApplicationFiled: June 8, 2022Publication date: September 29, 2022Inventors: John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link
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Patent number: 11390917Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.Type: GrantFiled: April 2, 2020Date of Patent: July 19, 2022Assignee: Bio-Rad Laboratories, Inc.Inventors: John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link
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Publication number: 20220047998Abstract: The present invention generally relates to droplet libraries and to systems and methods for the formation of libraries of droplets. The present invention also relates to methods utilizing these droplet libraries in various biological, chemical, or diagnostic assays.Type: ApplicationFiled: October 25, 2021Publication date: February 17, 2022Inventors: Darren Roy Link, John Brian Hutchison, Michael L. Samuels, Michael Weiner
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Publication number: 20200318157Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.Type: ApplicationFiled: April 2, 2020Publication date: October 8, 2020Inventors: John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link
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Patent number: 10612081Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.Type: GrantFiled: June 22, 2016Date of Patent: April 7, 2020Assignee: Bio-Rad Laboratories, Inc.Inventors: John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link
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Publication number: 20170002400Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.Type: ApplicationFiled: June 22, 2016Publication date: January 5, 2017Inventors: John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link
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Patent number: 9498761Abstract: Surfactants (e.g., fluorosurfactants) for stabilizing aqueous or hydrocarbon droplets in a fluorophilic continuous phase are presented. In some embodiments, fluorosurfactants include a fluorophilic tail soluble in a fluorophilic (e.g., fluorocarbon) continuous phase, and a headgroup soluble in either an aqueous phase or a lipophilic (e.g., hydrocarbon) phase. The combination of a fluorophilic tail and a headgroup may be chosen so as to create a surfactant with a suitable geometry for forming stabilized reverse emulsion droplets having a disperse aqueous or lipophilic phase in a continuous, fluorophilic phase. In some embodiments, the headgroup is preferably non-ionic and can prevent or limit the adsorption of molecules at the interface between the surfactant and the discontinuous phase. This configuration can allow the droplet to serve, for example, as a reaction site for certain chemical and/or biological reactions.Type: GrantFiled: April 15, 2015Date of Patent: November 22, 2016Assignees: Raindance Technologies, Inc., President and Fellows of Harvard CollegeInventors: Christian Holtze, David A. Weitz, John Brian Hutchison
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Patent number: 9399797Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.Type: GrantFiled: April 30, 2012Date of Patent: July 26, 2016Assignee: Raindance Technologies, Inc.Inventors: John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link
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Publication number: 20150217246Abstract: Surfactants (e.g., fluorosurfactants) for stabilizing aqueous or hydrocarbon droplets in a fluorophilic continuous phase are presented. In some embodiments, fluorosurfactants include a fluorophilic tail soluble in a fluorophilic (e.g., fluorocarbon) continuous phase, and a headgroup soluble in either an aqueous phase or a lipophilic (e.g., hydrocarbon) phase. The combination of a fluorophilic tail and a headgroup may be chosen so as to create a surfactant with a suitable geometry for forming stabilized reverse emulsion droplets having a disperse aqueous or lipophilic phase in a continuous, fluorophilic phase. In some embodiments, the headgroup is preferably non-ionic and can prevent or limit the adsorption of molecules at the interface between the surfactant and the discontinuous phase. This configuration can allow the droplet to serve, for example, as a reaction site for certain chemical and/or biological reactions.Type: ApplicationFiled: April 15, 2015Publication date: August 6, 2015Inventors: Christian Holtze, David A. Weitz, John Brian Hutchison
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Patent number: 9012390Abstract: Surfactants (e.g., fluorosurfactants) for stabilizing aqueous or hydrocarbon droplets in a fluorophilic continuous phase are presented. In some embodiments, fluorosurfactants include a fluorophilic tail soluble in a fluorophilic (e.g., fluorocarbon) continuous phase, and a headgroup soluble in either an aqueous phase or a lipophilic (e.g., hydrocarbon) phase. The combination of a fluorophilic tail and a headgroup may be chosen so as to create a surfactant with a suitable geometry for forming stabilized reverse emulsion droplets having a disperse aqueous or lipophilic phase in a continuous, fluorophilic phase. In some embodiments, the headgroup is preferably non-ionic and can prevent or limit the adsorption of molecules at the interface between the surfactant and the discontinuous phase. This configuration can allow the droplet to serve, for example, as a reaction site for certain chemical and/or biological reactions.Type: GrantFiled: August 7, 2007Date of Patent: April 21, 2015Assignee: Raindance Technologies, Inc.Inventors: Christian Holtze, David A. Weitz, John Brian Hutchison
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Publication number: 20150027892Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.Type: ApplicationFiled: October 10, 2014Publication date: January 29, 2015Inventors: Benjamin J. Miller, John Brian Hutchison, Andrew Wilson, Jonathan William Larson, Qun Zhong, Yevgeny Yurkovetsky, Darren R. Link, Mark Weary
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Publication number: 20120302448Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, a method for determining the nucleic acid make-up of a sample is provided.Type: ApplicationFiled: April 30, 2012Publication date: November 29, 2012Applicant: Raindance Technologies, Inc.Inventors: John Brian Hutchison, Jeffrey Charles Olson, Darren Roy Link
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Publication number: 20100105112Abstract: Surfactants (e.g., fluorosurfactants) for stabilizing aqueous or hydrocarbon droplets in a fluorophilic continuous phase are presented. In some embodiments, fluorosurfactants include a fluorophilic tail soluble in a fluorophilic (e.g., fluorocarbon) continuous phase, and a headgroup soluble in either an aqueous phase or a lipophilic (e.g., hydrocarbon) phase. The combination of a fluorophilic tail and a headgroup may be chosen so as to create a surfactant with a suitable geometry for forming stabilized reverse emulsion droplets having a disperse aqueous or lipophilic phase in a continuous, fluorophilic phase. In some embodiments, the headgroup is preferably non-ionic and can prevent or limit the adsorption of molecules at the interface between the surfactant and the discontinuous phase. This configuration can allow the droplet to serve, for example, as a reaction site for certain chemical and/or biological reactions.Type: ApplicationFiled: August 7, 2007Publication date: April 29, 2010Inventors: Christian Holtze, Jeremy Jon Agresti, David A. Weitz, Keunho Ahn, John Brian Hutchison, Andrew Gifiths, Abdesiam El Harrak, Olive John Miller, Jean-Christophe Barat, Valorie Taly, Michael Ryckelynck, Christoph Merton