Patents by Inventor John Byrne

John Byrne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210145906
    Abstract: The present invention provides compositions and methods of use pertaining to rAAV-mediated delivery of therapeutically effective molecules for treatment of diseases such as Pompe disease. These compositions in combination with various routes and methods of administration result in targeted expression of therapeutic molecules in specific organs, tissues and cells.
    Type: Application
    Filed: December 31, 2020
    Publication date: May 20, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Barry John Byrne, Darin J. Falk, Christina Pacak, Lara Robert DeRuisseau, Cathryn Mah, David D. Fuller
  • Patent number: 10984027
    Abstract: Disclosed techniques can generate content object summaries. Content of a content object can be parsed into a set of word groups. For each word group, at least one topic to which the word group pertains can be identified and it can be determined, via a user model, at least one weight of the plurality of weights corresponding to the topic(s). For each word group, a score can be determined for the word group based on the weight(s). A subset of the set of word groups can be selected based on the scores for the word group. A summary of the content object can be generated that includes the subset but that does not include one or more other word groups in the set of word groups that are not in the subset. At least part of the summary of the content object can be output.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: April 20, 2021
    Assignee: SRI International
    Inventors: Girish Acharya, John Niekrasz, John Byrnes, Chih-Hung Yeh
  • Publication number: 20210108226
    Abstract: Provided herein are methods related to co-packaging of multiple rAAV particles, e.g., by introducing multiple nucleic acid vectors encoding proteins or polypeptides or RNAs of interest into a single cell preparation.
    Type: Application
    Filed: August 10, 2020
    Publication date: April 15, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Barry John Byrne, Phillip A. Doerfler, Nathalie Clement
  • Publication number: 20210097780
    Abstract: Provided are a method and system for determining Advanced Driver Assistance Systems (ADAS) features in a first vehicle, the method comprising operating a computing device configured to:receive one or more identifiers of the first vehicle; identify the first vehicle based on the one or more identifiers; and determine from a vehicle database whether the identified first vehicle has ADAS features.
    Type: Application
    Filed: January 30, 2019
    Publication date: April 1, 2021
    Inventors: Jeff Aherne, John Byrne
  • Patent number: 10912804
    Abstract: The present invention provides compositions and methods of use pertaining to rAAV-mediated delivery of therapeutically effective molecules for treatment of diseases such as Pompe disease. These compositions in combination with various routes and methods of administration result in targeted expression of therapeutic molecules in specific organs, tissues and cells.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: February 9, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Barry John Byrne, Darin J. Falk, Christina Pacak, Lara Robert DeRuisseau, Cathryn Mah, David D. Fuller
  • Patent number: 10781459
    Abstract: Provided herein are methods related to co-packaging of multiple rAAV particles, e.g., by introducing multiple nucleic acid vectors encoding proteins or polypeptides or RNAs of interest into a single cell preparation.
    Type: Grant
    Filed: June 20, 2015
    Date of Patent: September 22, 2020
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Barry John Byrne, Phillip A. Doerfler, Nathalie Clement
  • Publication number: 20200193286
    Abstract: An artificial intelligence engine that has two or more modules cooperating with each other in order to create one or more machine learning models that use an adaptive semantic learning for knowledge representations and reasoning. The modules cause encoding the representations and reasoning from one or more sources in a particular field with terminology used by one or more human sources in that field into a set of rules that act as constraints and that are graphed into a neural network understandable by a first machine learning model, and then ii) adapting an intrepetation of that set of encoded rules. The understanding of that set of encoded rules is adapted by i) allowing for semantically similar terms and ii) by conclusions derived from training data, to create an understanding of that set of encoded rules utilized by the machine learning model and the AI engine.
    Type: Application
    Filed: May 8, 2018
    Publication date: June 18, 2020
    Inventors: John Byrnes, Richard Rohwer
  • Publication number: 20200138975
    Abstract: Provided herein are nucleic acids, recombinant adeno-associated viral particles, compositions and methods related to treating Friedreich's ataxia. In some examples, the nucleic acids, recombinant adeno-associated viral particles, compositions and methods involve us of a FXN coding sequence, a truncated FXN 3? UTR, and a prompter.
    Type: Application
    Filed: January 17, 2020
    Publication date: May 7, 2020
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Manuela Corti, Barry John Byrne
  • Patent number: 10617770
    Abstract: Provided herein are nucleic acids, recombinant adeno-associated viral particles, compositions and methods related to treating Friedreich's ataxia. In some examples, the nucleic acids, recombinant adeno-associated viral particles, compositions and methods involve use of a FXN coding sequence, a truncated FXN 3? UTR, and a promoter.
    Type: Grant
    Filed: April 23, 2016
    Date of Patent: April 14, 2020
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Manuela Corti, Barry John Byrne
  • Publication number: 20200020457
    Abstract: Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.
    Type: Application
    Filed: September 9, 2019
    Publication date: January 16, 2020
    Inventors: Timothy R. DeGrado, Mukesh K. Pandey, John Byrne
  • Patent number: 10526583
    Abstract: Provided herein are compositions and methods related to purification of recombinant adeno-associated virus (rAAV) particles.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: January 7, 2020
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Mark R. Potter, Barry John Byrne
  • Patent number: 10522261
    Abstract: Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61CU, 99mTC, 45-Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: December 31, 2019
    Assignees: Mayo Foundation for Medical Education and Research, Brigham and Women's Hospital, Inc.
    Inventors: Timothy R. DeGrado, Mukesh K. Pandey, John Byrne
  • Patent number: 10438712
    Abstract: Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: October 8, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Timothy R. DeGrado, Mukesh K. Pandey, John Byrne
  • Publication number: 20190258979
    Abstract: Methods and systems for managing inventory movements are disclosed. Transfer orders are issued to move inventory from location to location in response to real-time demand events. One method includes receiving an inventory request in response to demand signals. The inventory request is analyzed to determine if inventory needs to be moved within the supply chain to satisfy the request. Origin locations are identified that have available stock of the requested items. Transfer orders are issued for each movement on an individual item basis regardless of the type of event that prompted the transfer. The transfer management system responds in real-time to inventory demands from both online and in-store sales.
    Type: Application
    Filed: February 19, 2019
    Publication date: August 22, 2019
    Inventors: RAM AVINASH MULAY, DONGHOON KANG, DILLON JOHN BYRNE, GRADY MICHAEL JOHNSON, RACHEL RIANNA MAHONEY
  • Patent number: 10372704
    Abstract: Mathematical technologies for recommending content to a user based on a user's preferences are disclosed. Embodiments of these technologies can generate a probabilistic representation of a data set, and then adjust the probabilistic representation to reflect a user-specific weighting scheme. The user preference-adjusted representation of the data set can be used to recommend content to the user.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: August 6, 2019
    Assignee: SRI International
    Inventors: John Byrnes, Dayne Freitag, Robert Sasseen, Melinda Gervasio
  • Patent number: 10366108
    Abstract: Technology for classifying a data set includes extracting one or more features from items of the data set, computing a specificity measure for the extracted features, and measuring the similarity of the extracted features to a set of characteristic features associated with the property of one or more reference models.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: July 30, 2019
    Assignee: SRI International
    Inventors: John Byrnes, Christina Freyman
  • Publication number: 20190114298
    Abstract: Disclosed techniques can generate content object summaries. Content of a content object can be parsed into a set of word groups. For each word group, at least one topic to which the word group pertains can be identified and it can be determined, via a user model, at least one weight of the plurality of weights corresponding to the topic(s). For each word group, a score can be determined for the word group based on the weight(s). A subset of the set of word groups can be selected based on the scores for the word group. A summary of the content object can be generated that includes the subset but that does not include one or more other word groups in the set of word groups that are not in the subset. At least part of the summary of the content object can be output.
    Type: Application
    Filed: November 11, 2016
    Publication date: April 18, 2019
    Inventors: Girish Acharya, John Niekrasz, John Byrnes, Chih-Hung Yeh
  • Patent number: 10123155
    Abstract: A vehicle may display a user interface of an application based on command information received from a primary-connected device, and send the command information to a secondary-connected device providing an auxiliary user interface. The vehicle may also forward a command message received based on user input to the auxiliary user interface to the application of the primary-connected device. The vehicle may also access paired device data to confirm that the secondary-connected device is authorized to command the application; and forward the user input to the primary-connected device if the secondary-connected device is authorized to command the application.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: November 6, 2018
    Assignee: Livio, Inc.
    Inventors: Joey Ray Grover, Justin Dickow, Scott Smereka, Joel J. Fischer, John Byrne, Corey Maylone
  • Patent number: 10052935
    Abstract: Wireless sensors are included within zones of a physical space. A memory stores feature description data. A processor, in communication with the memory and the wireless sensors, is programmed to send, to a mobile device connected to one of the wireless sensors, a subset of the feature description data applicable to one of the zones in which the mobile device is located. The processor also is programmed to receive a request to update a feature of the one of the zones based on the feature description data, and apply the setting update when the mobile device has permission. The zones of a physical space may be seating zones of a vehicle, and the wireless sensors may be included within doors to the seating zones of the vehicle. The mobile device may determine a seating zone of the vehicle in which the mobile device is located using the wireless sensors.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: August 21, 2018
    Assignee: Livio, Inc.
    Inventors: Justin Dickow, Joey Ray Grover, Omar Makke, John Byrne
  • Patent number: D828311
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: September 11, 2018
    Assignee: Intermatic Incorporated
    Inventors: John Byrne, Curtis Leroy Cruver, IV