Patents by Inventor John C. Drach

John C. Drach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5654283
    Abstract: This invention relates to novel polysubstituted benzimidazoles and compositions and their use in the treatment of viral infections. The polysubstituted benzimidazoles and compositions of the present invention exhibit antiviral properties against viruses of the herpes family, particularly human cytomegalovirus (HCMV) and herpes simplex viruses (HSV).
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 5, 1997
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 5646125
    Abstract: This invention relates to novel polysubstituted benzimidazoles and compositions and their use in the treatment of viral infections. The polysubstituted benzimidazoles and compositions of the present invention exhibit antiviral properties against viruses of the herpes family, particularly human cytomegalovirus (HCMV) and herpes simplex viruses (HSV).
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 8, 1997
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 5633235
    Abstract: Triciribine and analogs are effective antiviral agents.
    Type: Grant
    Filed: July 5, 1994
    Date of Patent: May 27, 1997
    Assignees: Regents of the University of Michigan, Wake Forest University
    Inventors: Leroy B. Townsend, John C. Drach, Louis S. Kucera
  • Patent number: 5574058
    Abstract: Polysubstituted benzimidazoles and pharmaceutical compositions containing them as the active ingredients. These compounds and compositions exhibit antiviral activity against viruse of the herpes family, particularly human cytomegalovirus and herpes simplex viruses (HSV).
    Type: Grant
    Filed: May 3, 1993
    Date of Patent: November 12, 1996
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 5543413
    Abstract: This invention relates to a novel class of 4,5,6,7-substituted non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidines which exhibit both significantly lower levels of cytotoxicity and superior antiviral activity than known nucleoside, non-nucleoside, and non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidine derivatives, particularly against human DNA viruses such as cytomegalovirus (HCMV) and herpes simplex virus type 1 (HSV-1). These compounds are represented by the following formula: ##STR1## wherein R.sup.4 is -NH.sub.2 or -NHCH.sub.3 ;R.sup.5 is -CN,-CSNH.sub.2, or -CSeNH.sub.2 ;R.sup.6 is -H or -NH.sub.2 ; andR.sup.7 is selected from the group consisting ofaryls and aralkyls having 6 to 30 carbon atoms;aliphatic oxy-hydrocarbyls having 2 to 15 carbon atoms, lacking free hydroxyl groups and further lacking acyl or acyl derivatized groups; andoxy-hydrocarbyls having 6 to 30 carbon atoms, at least one aryl or aralkyl group, and only one oxy-group;with the proviso that if R.sup.
    Type: Grant
    Filed: December 15, 1994
    Date of Patent: August 6, 1996
    Assignee: Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach, Thomas E. Renau
  • Patent number: 5534535
    Abstract: Antiviral nucleoside analogues contain a substituted benzimidazole base attached to a carbocyclic ring in place of the conventional sugar residue. Particularly preferred compounds include those in which the 2-, 5- and 6- positions of the benzimidazole base are substituted by halogen. The compounds have activity against herpes virus especially cytomegalovirus and also hepatitis B virus infections.
    Type: Grant
    Filed: September 9, 1994
    Date of Patent: July 9, 1996
    Assignees: Burroughs Wellcome Co., The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach, Steven S. Good, Susan M. Daluge, Michael T. Martin
  • Patent number: 5360795
    Abstract: This invention relates to novel polysubstituted benzimidazoles and compositions and their use in the treatment of viral infections. The polysubstituted benzimidazoles and compositions of the present invention exhibit antiviral properties against viruses of the herpes family, particularly human cytomegalovirus (HCMV) and herpes simplex viruses (HSV). Preferred polysubstituted benzimidazoles of the invention are 2,5,6-Trichloro-1-(.beta.-D-5-deoxyribofuranosyl)benzimidazole and 2-bromo-5,6-dichloro-1-(5-deoxy-.beta.-D-ribofuranosyl)benzimidazole.
    Type: Grant
    Filed: October 21, 1992
    Date of Patent: November 1, 1994
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 5248672
    Abstract: This invention relates to novel polysubstituted benzimidazole nucleosides and compositions and their use in the treatment of viral infections, particulary those caused by human cytomegalovirus and herpes simplex virus. Such substituted compounds exhibit antiviral properties superior to their parent compounds and low leveSPONSORSHIPThis invention was made with government support under Contract No. NO1 Al 42554 and NO1 Al 72641 awarded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. The government has certain rights in this invention.
    Type: Grant
    Filed: November 1, 1990
    Date of Patent: September 28, 1993
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 4927830
    Type: Grant
    Filed: April 8, 1988
    Date of Patent: May 22, 1990
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach
  • Patent number: 4892865
    Abstract: This invention relates to the use of certain substituted pyrrolo[2,3-d]-pyrimidine nucleosides in the treatment of viral infections, in particular those caused by human immunodeficiency virus type 1, herpes simplex virus type 1 and human cytomegalovirus. These substituted compounds retain antiviral properties present in their parent compounds yet exhibit significantly decreased levels of cytotoxicity.
    Type: Grant
    Filed: December 1, 1987
    Date of Patent: January 9, 1990
    Assignee: The Regents of the University of Michigan
    Inventors: Leroy B. Townsend, John C. Drach, Steven H. Krawczyk
  • Patent number: 4777166
    Abstract: This invention relates to various compositions, comprising a 2-acetylprid thiosemicarbazone and a diol, which are useful in the treatment of viral infections.
    Type: Grant
    Filed: March 31, 1986
    Date of Patent: October 11, 1988
    Assignees: The United States of America as represented by the Secretary of the Army, The Regents of The University of Michigan
    Inventors: Sandra H. Smith, John C. Drach, Gordon L. Flynn
  • Patent number: 4596798
    Abstract: This invention relates to the use of various 2-acetylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom in the treatment of viral infections. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.
    Type: Grant
    Filed: March 30, 1982
    Date of Patent: June 24, 1986
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Charles Shipman, Jr., Daniel L. Klayman, Sandra H. Smith, John C. Drach