Abstract: The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Abstract: The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Abstract: Polypeptides and polynucleotides of the genes set forth in Table I and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing polypeptides and polynucleotides of the genes set forth in Table I in diagnostic assays.

Abstract: Polypeptides and polynucleotides of the genes set forth in Table I and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing polypeptides and polynucleotides of the genes set forth in Table I in diagnostic assays.

Abstract: An inline stacker receives a shingled stream of printed sheet products from a printing press, or finishing equipment, at line speed. A sheet counter at an infeed conveyor section controls the operation of the inline stacker. The infeed conveyor can pivot to a divert position where it feeds the stream to a bi-directional conveyor. A following gap generator section of the stacker has two conveyors with opposed movable ends that are physically separated in the conveying direction by a small gap. The infeed conveyor and gap generator conveyor sections carry the stream at a substantially constant speed, which can be the line speed. To produce a gap in the shingled stream that defines a bundle size, the movable conveyor ends defining the gap between the conveyor gap generator sections move downstream in unison at the speed of the upstream conveyor. At the same time, the speed of the downstream conveyor is briefly increased. The movable ends and the increased conveyor speed then return to their initial status.

Abstract: A hinge system for mounting a servo-motor to an apparatus is provided. The hinge system comprises a hinge plate securely connected to the apparatus, a door plate for connection to a servo-motor. A hinge assembly connects the door plate to the hinge plate. The servo-motor is attached to the door plate, and includes a coupling device. The coupling device is provided for operable engagement with a drive train in the apparatus when the door plate is in a closed position. An adapter plate can be connected to the door plate between the door plate and the servo-motor to allow for adjustment of an axis of the servo-motor.

Abstract: An apparatus and method for automatically folding a sheet of a media, for example a photographic paper, about a fold line such that a album page is formed. The photosensitive media has images only on one side. A heat activated adhesive sheet is provided between the sides of the photographic paper during folding. The adhesive sheet when exposed to heated and pressure rollers will cause the sides of the photographic media to be secured to form a single album page.

Abstract: A sequentially timed vacuum grip system holds a sheet and transports it through a folding nip defined by a pair of folding cylinders. At the nip, the folded edge of the sheet is released and simultaneously picked-up by the paired companion cylinder. Additional folds are achieved in the same manner by the use of additional cylinder pairs.

Abstract: The present invention is directed to a coating apparatus for a printing press. The apparatus includes an oscillating-metering roller having an internally disposed oscillation mechanism for delivering to a printed web a uniform fluid coating free from coater-imposed aberrations. The oscillation mechanism includes a translating means for translating a rotational movement into an oscillating movement, a velocity-modifying means for modifying the velocity of the rotational movement and a velocity-regulating means for providing a regulated, consistent velocity.

Abstract: A stacking apparatus for signatures includes a signature-carrying belt positioned with respect to incoming signatures to raise the trailing edge of each signature and form a reverse shingle stream of signatures. A retarding wheel positioned above the signature carrying belt slows the travel of the signatures as they enter the stacker. The signatures pass through a nip created between the retarding wheel and the signature carrying belt. The signature carrying belt carries the reverse shingle stream from a horizontal orientation to a vertical orientation and then to a signature collector that includes a transport belt. A belt drive activated by a sensor of the pressure in the stack collected on the belt carriers the stack in a direction away from the signature carrying belt. The collector includes a vertical barrier that supports the collected signatures in a vertical orientation and automatically adjusts its position to accommodate varying quantities of signatures stacked in the collector.

Abstract: A paper product traverses a straight line path through a folding apparatus defined by two folding stations that are mounted independently of one another. Each station includes supports, a central frame extending along the paper folding path, and belt arrangements for gripping, propelling and folding a laterally projecting portion of the paper. Each station is mounted for a lateral translation of the entire station perpendicular to the paper path. In the preferred form, this translation is accomplished with racks associated with each stand and pinions carried on a common drive shaft that engage the racks. Both stations also preferably include an arrangement for rotating the station as a whole in the horizontal plane to adjust the squareness of the fold.

Abstract: Disclosed is an automatic paper folding apparatus and method for folding cut sheet paper products, whether single sheets or multiple plies as in a "signature" that is already folded by a printing press. The apparatus of the invention contains at least one pair of opposed belts which continuously grip the products and carry then through the apparatus. At least one set of freely rotatable rollers is arrayed along the direction of travel. Each belt has a flat paper-gripping surface, a longitudinal groove on the opposite surface that receives a guide roller, and at least one side surface that slopes away from the folding line. Each roller has a conical forming surface. The angle of inclination of the conical surfaces of the rollers in a set increases incrementally along the direction of travel.

Abstract: Disclosed is an automatic paper folding apparatus and method for folding cut sheet paper products, whether single sheets or multiple piles as in a "signature" that is already folded by a printing press. The apparatus of the invention contains at least one pair of opposed belts which continuously grip the products and carry them through the apparatus. At least one set of freely rotatable rollers is arrayed along the direction of travel. Each belt has a flat paper-gripping surface, a longitudinal groove on the opposite surface that receives a guide roller, and at least one side surface that slopes away from the folding line. Each roller has a conical forming surface. The angle of inclination of the conical surfaces of the rollers in a set increases incrementally along the direction of travel. As the belts carry the sheets through the apparatus, they each engage the conical surface to fold the sheet against a belt with no substantial degree of relative movement between the sheets and either the belts or rollers.

Abstract: A rotary cutter for a printing press directs a web between a knife cylinder and an opposed anvil cylinder. The outer surface of the knife cylinder mounts one or more knife blade assemblies each having a sandwich construction. Each assembly includes at least one and usually two blades separated by a spacer bar. The assembly also includes a perforator blade and an ejector bar located on opposite sides of the spacer bar and set in recesses formed on the sides of the spacer bar. The perforator blade has laterally spaced sets of chisel-like teeth that impale trim pieces cut by the blades. The ejector bar reciprocates radially within the assembly to remove the trim piece from the teeth. The assembly is held together by two sets of bolts that allow the location of the blades to be set independently. A set of half rings each carrying radially projecting locating dowels are nested in circumferential grooves formed in the knife cylinder. Each ring is aligned against locating pins mounted in the knife cylinder.

Abstract: A rotary cutter for a printing press directs a web between a knife cylinder and an opposed anvil cylinder. The outer surface of the knife cylinder mounts one or more knife blade assemblies each having a sandwich construction. Each assembly includes at least one and usually two blades separated by a spacer bar. The assembly also includes a perforator blade and an ejector bar located on opposite sides of the spacer bar and set in recesses formed on the sides of the spacer bar. The perforator blade has laterally spaced sets of chisel-like teeth that impale trim pieces cut by the blades. The ejector bar reciprocates radially within the assembly to remove the trim piece from the teeth. The assembly is held together by two sets of bolts that allow the location of the blades to be set independently. A set of half rings each carrying radially projecting locating dowels are nested in circumferential grooves formed in the knife cylinder. Each ring is aligned against locating pins mounted in the knife cylinder.

Abstract: Web cutting apparatus employs a rotary knife cylinder with elongated, radially outwardly projecting knife blade assemblies spaced around its periphery. A rotary anvil cylinder spaced parallel to the knife cylinder carries a corresponding peripheral array of elongated anvils. When the two cylinders rotate, the knife blades bear against the anvils at the nip between the two cylinders. The knife blade assemblies are flexible and resilient so that each blade edge is biased against its anvil at the instant of interference, with a local force sufficient to cut web. Further, the natural frequency of the knife assemblies is selected to be considerably higher than those of the other machine parts so that the spacing between the knife blades and the anvils at the nip is substantially unaffected by vibrations of those parts. Also the apparatus efficiently removes trim strips produced by the web cuts.

Abstract: An apparatus piles a continuous stream of booklets in a stack, with a succeeding booklet in the stream being piled atop a preceding booklet. When the stack attains a predetermined size, the stack is ejected from the apparatus without stopping delivery to the apparatus of the continuous stream of booklets which are accumulated in a temporary holding stack, during ejection of the other stack. The temporary holding stack is depleted at a rate faster than it formed, following the ejection of the other stack.