Patents by Inventor John Dennis Bobyn

John Dennis Bobyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8309536
    Abstract: A bone implant comprises an active agent on at least a portion thereof. The active agent is locally deliverable to bone proximate the implant in at least a two-phased release scheme. A first phase rapidly releases a first quantity of the active agent, and at least a second phase gradually releases a second quantity of the active agent, whereby bone formation stimulated by the active agent is modulated. In one embodiment, a porous implant comprises a porous portion coated with a calcium phosphate compound and which is contacted with a bisphosphonate compound to form a bisphosphonate layer chemically bound to the calcium phosphate at the surface of the porous portion and to form bisphosphonate molecules being non-chemically attached inside the pores of the porous portion. The non-chemically attached bisphosphonate molecules are released in the subject at a rate greater than that of the chemically bound bisphosphonate layer.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: November 13, 2012
    Inventors: John Dennis Bobyn, Michael Tanzer
  • Patent number: 8071574
    Abstract: A bone implant comprises an active agent on at least a portion thereof. The active agent is locally deliverable to bone proximate the implant in at least a two-phased release scheme. A first phase rapidly releases a first quantity of the active agent, and at least a second phase gradually releases a second quantity of the active agent, whereby bone formation stimulated by the active agent is modulated. In one embodiment, a porous implant comprises a porous portion coated with a calcium phosphate compound and which is contacted with a bisphosphonate compound to form a bisphosphonate layer chemically bound to the calcium phosphate at the surface of the porous portion and to form bisphosphonate molecules being non-chemically attached inside the pores of the porous portion. The non-chemically attached bisphosphonate molecules are released in the subject at a rate greater than that of the chemically bound bisphosphonate layer.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: December 6, 2011
    Inventors: John Dennis Bobyn, Michael Tanzar
  • Publication number: 20110014265
    Abstract: A bone implant comprises an active agent on at least a portion thereof. The active agent is locally deliverable to bone proximate the implant in at least a two-phased release scheme. A first phase rapidly releases a first quantity of the active agent, and at least a second phase gradually releases a second quantity of the active agent, whereby bone formation stimulated by the active agent is modulated. In one embodiment, a porous implant comprises a porous portion coated with a calcium phosphate compound and which is contacted with a bisphosphonate compound to form a bisphosphonate layer chemically bound to the calcium phosphate at the surface of the porous portion and to form bisphosphonate molecules being non-chemically attached inside the pores of the porous portion. The non-chemically attached bisphosphonate molecules are released in the subject at a rate greater than that of the chemically bound bisphosphonate layer.
    Type: Application
    Filed: September 24, 2010
    Publication date: January 20, 2011
    Inventors: John Dennis Bobyn, Michael Tanzer
  • Patent number: 5658349
    Abstract: A prosthetic joint system is provided for use when replacement of bone is required. The system includes an elongated stem having a joint motion surface at one end and an outside surface which includes at least one tapered portion, a sleeve for fixation to the patient's bone which has an internal taper for locking engagement with the at least one tapered portion, and a bone replacement element which can be a bone graft. The system includes means for attaching the bone replacement element to the stem at a location between the joint motion surface and the sleeve. In the case of bone grafts, the system can include a second sleeve for implantation in the graft and a second tapered portion on the stem for locking engagement with the second sleeve. Preferably, a series of mating stems, sleeves, and bone replacement elements, or second sleeves in the case of bone grafts, are provided.
    Type: Grant
    Filed: January 27, 1994
    Date of Patent: August 19, 1997
    Assignee: Joint Medical Products Corporation
    Inventors: Caleb Emerson Brooks, Jan Janusz Krygier, John Dennis Bobyn, Alfred F. DeCarlo, Jr.