Patents by Inventor John Donnelly
John Donnelly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130195923Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.Type: ApplicationFiled: September 14, 2012Publication date: August 1, 2013Applicant: NOVARTIS VACCINES AND DIAGNOSTICS, INC.Inventors: Derek O'Hagan, Gary S. Ott, John Donnelly, Jina Kazzaz, Mildred Ugozzoli, Manmohan Singh, John Barackman
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Publication number: 20130195898Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.Type: ApplicationFiled: September 15, 2012Publication date: August 1, 2013Applicant: Novartis Vaccines and Diagnostics, Inc.Inventors: Derek O'Hagan, Gary S. Ott, John Donnelly, Jina Kazzaz, Mildred Ugozzoli, Manmohan Singh, John Barackman
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Publication number: 20130196352Abstract: The disclosure provides compositions, methods and kits for assessing immunogenicity, potency, or both, of meningococcal capsular saccharide vaccines. The assessment is based upon measurement of binding of a bactericidal antibody to a capsular saccharide component in the vaccine.Type: ApplicationFiled: September 2, 2011Publication date: August 1, 2013Applicant: NOVARTIS AGInventors: Cristiana Balocchi, Enrico Luzzi, Marilena Paludi, Marzia Monica Giuliani, John Donnelly, Elena Mori
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Patent number: 8309139Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.Type: GrantFiled: April 18, 2006Date of Patent: November 13, 2012Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Derek O'Hagan, Gary S. Ott, John Donnelly, Jina Kazzaz, Mildred Ugozzoli, Manmohan Singh, John Barackman
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Publication number: 20120207783Abstract: Provided herein are HIV vaccines comprising HIV polypeptide-encoding DNA adsorbed to PLG and/or HIV proteins. Also provided are methods of using these vaccines to generate immune responses in a subject.Type: ApplicationFiled: December 22, 2011Publication date: August 16, 2012Inventors: John DONNELLY, Susan W. BARNETT, Derek O'HAGAN
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Patent number: 8206749Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.Type: GrantFiled: February 9, 2000Date of Patent: June 26, 2012Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Derek O'Hagan, Gary S. Ott, John Donnelly, Jina Kazzaz, Mildred Ugozzoli, Manmohan Singh, John Barackman
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Publication number: 20110300171Abstract: The invention relates to immunization against pathogenic bacterial strains which express or can express multiple factor H binding proteins. Certain aspects of the invention include vaccine compositions comprising at least two factor H binding proteins derived from a pathogenic bacterial strain which expresses multiple facto H binding proteins.Type: ApplicationFiled: September 14, 2009Publication date: December 8, 2011Applicants: HUMANITAS MIRASOLE S.P.A., NOVARTIS VACCINES AND DIAGNOSTICS S.R.L.Inventors: Silvana Savino, John Donnelly, Rino Rappuoli, Mariagrazia Pizza, Barbara Bottazzi
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Publication number: 20100086565Abstract: A nucleic acid vector comprising: (i) a promoter; (ii) a sequence encoding a HML-2 polypeptide operably linked to said promoter; and (iii) a selectable marker. Preferred vectors comprise: (I) a eukaryotic promoter; (ii) a sequence encoding a HML-2 polypeptide downstream of and operably linked to said promoter, (iii) a prokaryotic selectable marker; (iv) a prokaryotic origin of replication; and (v) a eukaryotic transcription terminator downstream of and operably linked to said sequence encoding a HML-2 polypeptide. Vectors of the invention are particularly useful for expression of HML-2 polypeptides either in vitro (e.g. for later purification). Or in vivo (e.g. for nucleic acid immunization). They are well suited to nucleic acid immunization against prostrate tumors. A preferred HML-2 is PCAV, which is located in chromosome 22 at 20.428 megabases (22q11.2).Type: ApplicationFiled: June 13, 2003Publication date: April 8, 2010Applicant: Novartis vaccines and diagnostics IncInventors: Stephen F. Hardy, John Donnelly, Jan zur Megede
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Publication number: 20100035234Abstract: The present invention is directed to methods, assays and compositions for implementing such methods and assays for assessing efficacy of individual components in multi-component vaccines and for assessing efficacy of a vaccine against a pathogen. In one aspect, the method of assessing efficacy of a vaccine against a pathogen is a quick assay that tests for an activity correlated with efficacy such as binding in an ELISA rather than requiring the time and expense of an assay that detects actual bactericidal activity. In another aspect, the method for testing the efficacy of an individual component in a multi-component vaccine includes obtaining an immune sample from a subject inoculated with the multi-component vaccine; blocking the portion of the immune sample that recognizes the individual component such as by addition of the individual component, and testing the efficacy of the immune sample to respond to the pathogen.Type: ApplicationFiled: May 19, 2009Publication date: February 11, 2010Applicant: Novartis AGInventors: John Donnelly, Ping Wu, George Santos, Marzia Monica Giuliani, William Andrews, Jie Chen
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Publication number: 20090238841Abstract: Provided herein are HIV vaccines comprising HIV polypeptide-encoding DNA adsorbed to PLG and/or HIV proteins. Also provided are methods of using these vaccines to generate immune responses in a subject.Type: ApplicationFiled: February 2, 2009Publication date: September 24, 2009Inventors: John Donnelly, Susan W. Barnett, Derek O'Hagan
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Publication number: 20090019090Abstract: The invention provides an improved method and system for capturing live events or performances onto portable storage devices as high quality recordings. The portable storage devices may be removably connected to the system or in wireless communication with the system. The signal from the event may include audio and/or visual data, and may be captured as a media file in a memory archive and simultaneously as distribution media files on the portable storage devices. A checksum, cyclic redundancy check, or the like may be implemented to verify that each distribution media is the same as the media file.Type: ApplicationFiled: March 24, 2008Publication date: January 15, 2009Applicant: ADERRA INC.Inventor: Edward John Donnelly, III
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Publication number: 20080026071Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. Also provided are microparticles in the form of submicron emulsions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. The surface of the microparticles efficiently adsorb polypeptides, such as antigens, and nucleic acids, such as ELVIS vectors and other vector constructs, containing heterologous nucleotide sequences encoding biologically active macromolecules, such as polypeptides, antigens, and adjuvants. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and uses of the microparticle compositions for vaccines are also provided.Type: ApplicationFiled: January 16, 2007Publication date: January 31, 2008Inventors: Derek O'Hagan, Gillis Otten, John Donnelly, John Polo, Susan Barnett, Manmohan Singh, Jeffrey Ulmer, Thomas Dubensky
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Publication number: 20070116709Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(?-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided.Type: ApplicationFiled: April 18, 2006Publication date: May 24, 2007Inventors: Derek O'Hagan, Gary Ott, John Donnelly, Jina Kazzaz, Mildred Ugozzoli, Manmohan Singh, John Barackman
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Publication number: 20060257852Abstract: An outbreak of a virulent respiratory virus, now known as Severe Acute Respiratory Syndrome (SARS), was identified in Hong Kong, China and a growing number of countries around the world in 2003. The invention relates to nucleic acids and proteins from the SARS coronavirus. These nucleic acids and proteins can be used in the preparation and manufacture of vaccine formulations, diagnostic reagents, kits, etc. The invention also provides methods for treating SARS by administering small molecule antiviral compounds, as well as methods of identifying potent small molecules for the treatment of SARS.Type: ApplicationFiled: April 9, 2004Publication date: November 16, 2006Applicant: Chiron CorporationInventors: Rino Rappuoli, Vega Masignani, Konrad Stadler, Jens Gregersen, David Chien, Jang Han, John Polo, Amy Weiner, Michael Houghton, Hyun Song, Mi-Young Seo, John Donnelly, Hans Klenk, Nicholas Valiante
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Publication number: 20060110736Abstract: Provided herein are HIV vaccines comprising HIV polypeptide-encoding DNA adsorbed to PLG and/or HIV proteins. Also provided are methods of using these vaccines to generate immune responses in a subject.Type: ApplicationFiled: October 7, 2003Publication date: May 25, 2006Inventors: John Donnelly, Susan Barnett, Derek O'Hagan
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Publication number: 20050074752Abstract: This invention relates to novel formulations of pharmaceutical products, specifically nucleic acid vaccine products. The nucleic acid vaccine products, when introduced directly into muscle cells, induce the production of immune responses which specifically recognize Hepatitis C virus (HCV).Type: ApplicationFiled: September 17, 2003Publication date: April 7, 2005Applicant: Merck & Co., Inc.Inventors: John Donnelly, Margaret Liu, John Shiver, Tong-Ming Fu
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Publication number: 20030138453Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(&agr;-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nomonic detergents. Also provided are microparticles in the form of submicron emulsions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. The surface of the microparticles efficiently adsorb polypeptides, such as antigens, and nucleic acids, such as ELVIS vectors and other vector constructs, containing heterologous nucleotide sequences encoding biologically active macromolecules, such as polypeptides, antigens, and adjuvants. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and uses of the microparticle compositions for vaccines are also provided.Type: ApplicationFiled: September 28, 2001Publication date: July 24, 2003Inventors: Derek O'Hagan, Gillis Otten, John Donnelly, John Polo, Susan Barnett, Manmohan Singh, Jeffrey Ulmer, Thomas Dubensky
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Patent number: 6007216Abstract: An emergency flasher is provided including a housing having an inboard extent and an outboard extent rotatably coupled to the inboard extent. A flasher bulb is mounted on the outboard extent for intermittently illuminating upon the actuation thereof. Next included is a coupling assembly mounted on the housing for coupling the same to a recipient surface.Type: GrantFiled: February 26, 1998Date of Patent: December 28, 1999Inventor: John Donnelly
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Patent number: 5169202Abstract: An improved fold-down tailgate for use on a truck-like vehicle is disclosed. The tailgate of the present invention employs a slotted work surface which permits the ready attachment of various construction implements, such as cargo ramps, extended work surfaces, and a wide variety of vises, clamps and tie-down devices. The tailgate provides improved functionality while maximizing the amount of cargo space in the vehicle.Type: GrantFiled: December 26, 1991Date of Patent: December 8, 1992Inventors: John Cupp, William D. Turner, John Donnelly