Abstract: A compound of formula (I): ##STR1## wherein R.sup.1 represents a hydrogen or halogen atom, or a cyano group;R.sup.2 represents an optionally substituted carbocyclic group having 6 to 10 ring atoms and containing at least one aromatic ring; an optionally substituted heterocyclic group having 5 to 10 ring atoms, including 1 to 4 heteroatoms selected from O, N and S, and containing at least one aromatic ring; or an optionally substituted C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl- C.sub.1-6 alkyl, or C.sub.1-10 alkyl group;R.sup.3 and R.sup.4, which may be the same or different, each represent a hydrogen or halogen atom, or a C.sub.1-6 alkyl group optionally substituted by 1 to 3 halogen atoms; andR.sup.5 represents a hydrogen atom, a hydroxyl group, or a C.sub.1-6 alkyl group, optionally substituted by hydroxy, carboxy, amino or mono- or di-(C.sub.1-4)alkyl amino,and salts and other physiologically functional derivative thereof.The compounds are useful in the treatment of parasitic infections eg.

Abstract: Tricyclic compounds of formula (I) ##STR1## wherein X.sup.1 is a carboxyl or 5-tetrazolyl groupX.sup.2 is carbonyl or methyleneX.sup.3 is hydroxyl or a group --X.sup.4 (C.sub.n H.sub.2n)X.sup.5whereX.sup.4 is oxygen or sulphurX.sup.5 is hydrogen or a group --OX.sup.6whereX.sup.6 is hydrogen, alkanoyl of 1 to 4 carbon atoms or a group --(C.sub.m H.sub.2m)X.sup.7whereX.sup.7 is hydrogen or a group --OX.sup.8whereX.sup.8 is hydrogen or alkanoyl of 1 to 4 carbon atoms and m and n are each, independently, an integer from 1 to 4, together with salts thereof,provided that when X.sup.5 is a group --OX.sup.6 then n is always greater than 1 and X.sup.4 and X.sup.5 are attached to different carbon atomsand that when X.sup.7 is a group --OX.sup.8 then m is always greater than 1 and no single carbon atom in the radical --(C.sub.m H.sub.2m)-- is attached to two oxygen atoms.

Abstract: A method of treating or preventing viral infections, in particular rhinovirus infections comprising the administration of an effective amount of a 2-phenyltetralin derivative or a heterocyclic analogue thereof. Pharmaceutical compositions containing these compounds, and some novel compounds are also disclosed.

Abstract: Use of compounds of formula (I) ##STR1## to provide a more effective delivery of oxygen to the tissues of a mammalian, including human, recipient.In vivo applications include the relief or amelioration of conditions wherein there is tissue hypoxia; in vitro the compounds are of use in the storage of mammalian, including human, red blood cells to maintain their oxygen-delivery capacity and prolong their useful storage life.Also provided is a sterile, sealed vessel containing an anticoagulant, a non-toxic amount of a compound of formula (I) and optionally mammalian, in particular human, red blood cells.

Abstract: Use of compounds of formula (I) ##STR1## to provide a more effective delivery of oxygen to the tissues of a mammalian, including human, recipient.In vivo applications include the relief or amelioration of conditions wherein there is tissue hypoxia; in vitro the compounds are of use in the storage of mammalian, including human, red blood cells to maintain their oxygen-delivery capacity and prolong their useful storage life.Also provided is a sterile, sealed vessel containing an anticoagulant, a non-toxic amount of a compound of formula (I) and optionally mammalian, in particular human, red blood cells.

Abstract: 2-Pyridyl chroman and derivatives thereof have been discovered to have potent anti-viral activities, i.e. particular against rhinovirus. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulations containing the compounds of this invention and the treatment of viral infections with these formulations are all disclosed. 2-(3-Pyridyl)chroman and 6-chloro-2-(3-pyridyl)chroman are examples of especially active compounds of this invention.

Abstract: Novel compounds of formula (IID) ##STR1## wherein either both X and Y represent groups independently selected from amino and lower alkylamino, or one of X and Y represents a group selected from amino and lower alkylamino and the other of X and Y represents a hydrogen atom have been found to be active against rhinoviruses and other viruses. Processes for producing these compounds include reduction of flavanone derivatives or of flavenes. Alternatively, reductive cyclization of chalcones affords the compounds. These may also be prepared by condensation of o-(substituted methyl)phenols with styrene derivatives.Pharmaceutical formulations and methods for the administration of the compounds are described.

Abstract: A method of treating or preventing viral infections, in particular rhinovirus infections comprising the administration of an effective amount of a flavan derivative of formula (I). ##STR1## Pharmaceutical compositions containing these compounds, and some novel compounds are also disclosed.

Abstract: Certain tricyclic sulphone compounds each of which is substituted in the 1-,2-,3- or 4-position by a carboxyl or (5-tetrazolyl) group and each of which is optionally substituted in the 5-,6-,7- or 8-position by a second carboxyl or (5-tetrazolyl) group or a substituent selected from cyano, halogen, nitro, alkyl, alkoxy, acyl, amino, acylamino, thioalkyl, alkylsulphinyl and alkylsulphonyl, as well as salts, and optionally substituted esters and amides of the carboxyl substituted compounds and alkyl derivatives of the tetrazolyl substituted compounds, are useful for the relief or prophylaxis of allergic conditions.

Abstract: Certain tricyclic sulphone compounds each of which is substituted in the 1-, 2-, 3- or 4-position by a carboxyl or (5-tetrazolyl) group and each of which is optionally substituted in the 5-, 6-, 7- or 8-position by a second carboxyl or (5-tetrazolyl) group or a substituent selected from cyano, halogen, nitro, alkyl, alkoxy, acyl, amino, acylamino, thioalkyl, alkylsulphinyl and alkylsulphonyl, as well as salts, and optionally substituted esters and amides of the carboxyl substituted compounds and alkyl derivatives of the tetrazolyl substituted compounds, are useful for the relief or prophylaxis of allergic conditions.