Patents by Inventor John F. Gerster

John F. Gerster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxazolo, thiazolo and selenazolo [4,5-c] quinolin-4-amines and analogs thereof
    Patent number: 6323200
    Abstract: Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.
    Type: Grant
    Filed: June 14, 2000
    Date of Patent: November 27, 2001
    Assignee: 3M Innovative Properties Company
    Inventors: John F. Gerster, Kyle J. Lindstrom, Gregory J. Marszalek, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
  • Imidazonaphthyridines
    Patent number: 6194425
    Abstract: Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are also disclosed.
    Type: Grant
    Filed: December 11, 1998
    Date of Patent: February 27, 2001
    Assignee: 3M Innovative Properties Company
    Inventors: John F. Gerster, Kyle J. Lindstrom, Stephen L. Crooks, Philip D. Heppner, Gregory J. Marszalek, Peter V. Maye, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
  • Process for preparing imidazoquinolinamines
    Patent number: 6150523
    Abstract: A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: November 21, 2000
    Assignee: 3M Innovative Properties Company
    Inventors: John F. Gerster, Kyle J. Lindstrom
  • Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
    Patent number: 6110929
    Abstract: Thiazolo-, oxazolo- and selenazolo[4,5-c]quinolin-4-amines and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: August 29, 2000
    Assignee: 3M Innovative Properties Company
    Inventors: John F. Gerster, Kyle J. Lindstrom, Gregory J. Marszalek, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
  • Process for preparing imidazoquinolinamines
    Patent number: 5998619
    Abstract: A process for preparing 1H-imidazo[4,5-c]quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo[4,5-c]tetrazolo[1,5-a]quinoline with triphenylphosphine and hydrolyzing the product thereof.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: December 7, 1999
    Assignee: 3M Innovative Properties Company
    Inventors: John F. Gerster, Kyle J. Lindstrom
  • 1-substituted, 2-substituted 1H-imidazo[4,5-c] quinolin-4-amines
    Patent number: 5977366
    Abstract: 1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermediates for preparing such compounds, pharmaceutical compositions containing such compounds, and pharmacological methods of using such compounds.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: November 2, 1999
    Assignee: 3M Innovative Properties Company
    Inventors: John F. Gerster, Stephen L. Crooks, Kyle J. Lindstrom
  • Fused cycloalkylimidazopyridines
    Patent number: 5886006
    Abstract: 6,7-propylene-, butylene-, or pentylene-bridged imidazopyridin-4-amines that induce interferon (.alpha.) biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon (.alpha.) biosynthesis and treating viral infections involving the use of such compounds.
    Type: Grant
    Filed: March 6, 1997
    Date of Patent: March 23, 1999
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Nick Nikolaides, John F. Gerster
  • 1H-imidazo?4,5-c!quinolin-4-amines
    Patent number: 5756747
    Abstract: Novel 1H-imidazo?4,5-c!quinolin-4-amines are disclosed. The compounds function as antiviral agents and they are potential synthetic intermediates in the preparation of known antiviral agents and labeled known antiviral agents. Processes for the preparation of the compounds, methods for their antiviral use, and methods of inducing interferon biosynthesis, are also described.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: May 26, 1998
    Assignee: Riker Laboratories, Inc.
    Inventor: John F. Gerster
  • Process for reparing imidazoquinolinamines
    Patent number: 5741908
    Abstract: A process for preparing 1H-imidazo?4,5-c!quinolin-4-amines is disclosed. The process involves reacting a 6H-imidazo?4,5-c!tetrazolo?1,5-a!quinoline with triphenylphosphine and hydrolyzing the product thereof.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: April 21, 1998
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: John F. Gerster, Kyle J. Lindstrom
  • 1-substituted, 2-substituted 1H-imidazo?4,5-C!quinolin-4-amines
    Patent number: 5741909
    Abstract: 1-substituted, 2-substituted 1H-imidazo?4,5-c!-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermediates for preparing such compounds, pharmaceutical compositions containing such compounds, and pharmacological methods of using such compounds.
    Type: Grant
    Filed: January 28, 1997
    Date of Patent: April 21, 1998
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: John F. Gerster, Stephen L. Crooks, Kyle J. Lindstrom
  • 1-substituted 1H-imidazo-?4,5-c!quinolin-4-amines
    Patent number: 5714608
    Abstract: 1-substituted 1H-imidazo?4,5-c!quinolin-4-amines, active as immunomodulators and antiviral agents. Also, intermediates in the preparation of such compounds, pharmaceutical compositions, and pharmacological methods of use.
    Type: Grant
    Filed: March 22, 1996
    Date of Patent: February 3, 1998
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: John F. Gerster
  • Fused cycloalkylimidazopyridines
    Patent number: 5648516
    Abstract: 6,7-propylene-, butylene-, or pentylene-bridged imidazopyridin-4-amines that induce interferon (.alpha.) biosynthesis in human cells, their pharmaceutical compositions containing such compounds and methods of inducing interferon (.alpha.) biosynthesis and treating viral infections involving the use of such compounds are disclosed.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: July 15, 1997
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Nick Nikolaides, John F. Gerster
  • Intermediate compounds of fused cycloalkylimidazopyridines
    Patent number: 5627281
    Abstract: 6,7-propylene-, butylene-, or pentylene-bridged imidazopyridin-4-amines and their intermediate compounds are described. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon (.alpha.) biosynthesis and treating vital infections involving the use of such compounds.
    Type: Grant
    Filed: July 3, 1996
    Date of Patent: May 6, 1997
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Nick Nikolaides, John F. Gerster
  • 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
    Patent number: 5605899
    Abstract: 1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermediates for preparing such compounds, pharmaceutical compositions containing such compounds, and pharmacological methods of using such compounds.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: February 25, 1997
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: John F. Gerster, Stephen L. Crooks, Kyle J. Lindstrom
  • 1-substituted 1H-imidazo-[4,5-c]quinolin-4-amines
    Patent number: 5525612
    Abstract: 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines, active as immunomodulators and antiviral agents. Also, intermediates in the preparation of such compounds, pharmaceutical compositions, and pharmacological methods of use.
    Type: Grant
    Filed: June 23, 1994
    Date of Patent: June 11, 1996
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: John F. Gerster
  • Fused cycloalkylimidazopyridines as inducer of interferon .alpha. biosynthesis
    Patent number: 5444065
    Abstract: 6,7-propylene-, butylene-, or pentylene-bridged imidazopyridin-4-amines that induce interferon (.alpha.) biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon (.alpha.) biosynthesis and treating viral infections involving the use of such compounds.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: August 22, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Nick Nikolaides, John F. Gerster
  • 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
    Patent number: 5389640
    Abstract: 1-substituted, 2-substituted 1H-imidazo[4,5-c]-quinolin-4-amines are disclosed. These compounds function as antiviral agents, they induce biosynthesis of interferon, and they inhibit tumor formation in animal models. This invention also provides intermediates for preparing such compounds, pharmaceutical compositions containing such compounds, and pharmacological methods of using such compounds.
    Type: Grant
    Filed: August 28, 1992
    Date of Patent: February 14, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: John F. Gerster, Stephen L. Crooks, Kyle J. Lindstrom
  • Process for imidazo[4,5-C]quinolin-4-amines
    Patent number: 5367076
    Abstract: A process is disclosed for preparing 1-substituted-1H-imidazo[4,5-c]quinolin-4-amines. The process involves reacting a 1-substituted-1H-imidazo[4,5-c]quinoline-5-oxide with an acylating agent and reacting the product thereof with an aminating agent.
    Type: Grant
    Filed: April 30, 1992
    Date of Patent: November 22, 1994
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: John F. Gerster
  • Fused cycloalkylimidazopyridines
    Patent number: 5352784
    Abstract: [6,7]-propylene-, -butylene- or -pentylene-fused imidazopyridin-4-amines that induce interferon (.alpha.) biosynthesis in human cells. Also disclosed are pharmaceutical compositions containing such compounds and methods of inducing interferon (.alpha.) biosynthesis and treating viral infections involving the use of such compounds.
    Type: Grant
    Filed: July 15, 1993
    Date of Patent: October 4, 1994
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Nick Nikolaides, John F. Gerster
  • 1-substituted 1H-imidazo-[4,5-C]quinolin-4-amines
    Patent number: 5346905
    Abstract: 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines, active as immunomodulators and antiviral agents. Also, intermediates in the preparation of such compounds, pharmaceutical compositions, and pharmacological methods of use.
    Type: Grant
    Filed: August 21, 1992
    Date of Patent: September 13, 1994
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: John F. Gerster