Abstract: Compounds which inhibit microbial growth or attenuate the virulence of pathogen microorganisms. Compounds of the invention inhibit UDP-galactopyranose mutase (UGM) and have activity as inhibitors of microbial growth of microorganisms which contain this enzyme and particularly those microorganisms in which this enzyme is responsible for the incorporation of galactofuranose residues, particularly for uridine 5?-diphosphate (UDP) galactopyranose mutase. Compounds of the invention inhibit UDP-galactopyranose mutase (UGM) and have activity to attenuate virulence of pathogenic microorganisms, including mycobacteria.

Abstract: Compounds which inhibit microbial growth or attenuate the virulence of pathogen microorganisms. Compounds of the invention inhibit UDP-galactopyranose mutase (UGM) and have activity as inhibitors of microbial growth of microorganisms which contain this enzyme and particularly those microorganisms in which this enzyme is responsible for the incorporation of galactofuranose residues, particularly for uridine 5?-diphosphate (UDP) galactopyranose mutase. Compounds of the invention inhibit UDP-galactopyranose mutase (UGM) and have activity to attenuate virulence of pathogenic microorganisms, including mycobacteria.

Abstract: Compounds which inhibit microbial growth or attenuate the virulence of pathogen microorganisms. Compounds of the invention inhibit UDP-galactopyranose mutase (UGM) and have activity as inhibitors of microbial growth of microorganisms which contain this enzyme and particularly those microorganisms in which this enzyme is responsible for the incorporation of galactofuranose residues, particularly for uridine 5?-diphosphate (UDP) galactopyranose mutase. Compounds of the invention inhibit UDP-galactopyranose mutase (UGM) and have activity to attenuate virulence of pathogenic microorganisms, including mycobacteria.

Abstract: A payout tube adapted to be secured to a container having wire or cable contained therein, has a flange at the entrance end thereof. The flange has a radiused surface wherein the radius is greater than the critical or kinking radius R.sub.c, and a central opening where the radiused surface fairs into the inner wall of the tube, with the inner wall being substantially tangential to the radiused surface. A plurality of strengthening ribs are located on the underside of the flange and extend along the outer wall of the tube, with certain ones of the ribs intersecting other ribs at right angles thereto. Mounting mechanism located at the exit end of the tube also has strengthening ribs, with strengthening members intersecting the ribs at right angles thereto. Due to the configuration of the flange, tube, ribs and mounting mechanism, the payout tube can be formed or molded as one integral unit with a consequent reduction in production costs.