Patents by Inventor John F. Place

John F. Place has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4962047
    Abstract: Gas containing granules of a resiliently compressible material having a density variable with pressure are used as a solid phase support in liquid phase reactions such in immunological reactions. Varying pressure causes the density of the granules to change and is used for mixing and separating the granules in liquid phase. In an immunological reaction, the granules having an attached antibody are combined with a solution containing an antigen, then varying pressure is applied to the solution to mix the granules in the solution to fix the antigen to the antibody and then pressure on the solution is varied to force the granules to the top or bottom of the solution whereby the solution can be separated from the granules.
    Type: Grant
    Filed: October 28, 1986
    Date of Patent: October 9, 1990
    Assignee: IntraCel Corporation
    Inventor: John F. Place
  • Patent number: 4810183
    Abstract: A mould for the casting of thin, cross-linked, polymerized resin films is subjected, when being filled with the liquid to be polymerized, to a centrifugal force field exceeding that of the earth gravitation field, the whole being for equalizing the intimate structure of the polymer and to expel therefrom the bubbles of gas possibly present therein. After curing the gel, a mixture of compounds to be separated by the application of an electric field is introduced into the gel and the latter is subjected to electrophoresis within the mould itself.
    Type: Grant
    Filed: November 10, 1987
    Date of Patent: March 7, 1989
    Assignee: IntraCel Corporation
    Inventors: John F. Place, Andre Bregnard
  • Patent number: 4668636
    Abstract: An apparatus responsive to optical changes in a waveguide when the latter is contacted with an analyte capable of reacting with a specific reactant thereto attached to the surface of said guide involves, for containing the analyte, an interchangeable round bottomed cuvette temporarily held by a suitably shaped carrier in working relationship with the optical components of the apparatus, this arrangement ensuring a correct optical orientation thereof relative to said component whatever the exact positioning of the cuvette.
    Type: Grant
    Filed: October 31, 1985
    Date of Patent: May 26, 1987
    Assignee: Battelle Memorial Institute
    Inventors: Anthony Ringrose, Ranald M. Sutherland, Claus Dahne, John F. Place
  • Patent number: 4652354
    Abstract: A mould for the moulding by casting of thin, cross-linked, polymerized resin films is used which is subjected, when being filled with the liquid to be polymerized, to a centrifugal force field exceeding that of the earth gravitation field, the whole being for equalizing the intimate structure of the polymer and to expel therefrom the bubbles of gas possibly present therein.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: March 24, 1987
    Assignee: Battelle Memorial Institute
    Inventors: John F. Place, Andre Bregnard
  • Patent number: 4608344
    Abstract: An analyte in solution is made to react with a spectific reactant coated on the wave-guide thus modifying the optical properties thereof. The index of refraction of the wave-guide material is higher than that of the reaction medium which ensures that a light signal injected into said guide be carried by multiple total reflection, the distance of penetration of the evanescent wave associated with the totally reflected signal being of the same order of magnitude or greater than the thickness of the analyte-reactant product layer.
    Type: Grant
    Filed: May 18, 1983
    Date of Patent: August 26, 1986
    Assignee: Battelle Memorial Institute
    Inventors: Timothy J. N. Carter, Claus Dahne, John F. Place
  • Patent number: RE33064
    Abstract: An analyte in solution is made to react with a specific reactant coated on the wave-guide thus modifying the optical properties thereof. The index of refraction of the wave-guide material is higher than that of the reaction medium which ensures that a light signal injected into said guide be carried by multiple total reflection, the distance of penetration of the evanescent wave associated with the totally reflected signal being of the same order of magnitude or greater than the thickness of the analyte-reactant product layer.
    Type: Grant
    Filed: October 9, 1987
    Date of Patent: September 19, 1989
    Assignee: Prutec Limited
    Inventors: Timothy J. N. Carter, Claus Dahne, John F. Place