Patents by Inventor John F. Warner

John F. Warner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of suppressing immune response by gene therapy
    Publication number: 20030091546
    Abstract: Tissue cells of an animal transformed with a multivalent recombinant vector construct are provided. The vector construct expresses a therapeutic protein and either (a) a second protein or active portion thereof capable of inhibiting MHC antigen presentation; (b) an antisense message capable of inhibiting MHC antigen presentation; or (c) a ribozyme capable of inhibiting MHC antigen presentation. Pharmaceutical compositions comprising such multivalent constructs are also provided. The transformed tissue cells are particularly useful within methods for suppressing an immune response.
    Type: Application
    Filed: June 26, 2002
    Publication date: May 15, 2003
    Inventors: Jack R. Barber, John F. Warner, Michael J. Irwin, Thomas W. Dubensky, Carlos E. Ibanez, Douglas J. Jolly
  • Method for inhibiting human tumor cells
    Patent number: 6410326
    Abstract: Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 25, 2002
    Assignee: Chiron Corporation
    Inventors: Harry E. Gruber, Douglas J. Jolly, James G. Respess, Paul K. Laikind, Jack R. Barber, Daniel C. St. Louis, Sunil D. Chada, Stephen M. W. Chang, John F. Warner
  • Method for making reflection defective retroviral vectors for infecting human cells
    Patent number: 5856185
    Abstract: Recombinant retroviruses carrying a vector construct capable of preventing, inhibiting, stabilizing or reversing infectious, cancerous or auto-immune diseases are disclosed. More specifically, the recombinant retroviruses of the present invention are useful for (a) stimulating a specific immune response to an antigen or a pathogenic antigen; (b) inhibiting a function of a pathogenic agent, such as a virus; and (c) inhibiting the interaction of an agent with a host cell receptor. In addition, eucaryotic cells infected with, and pharmaceutical compositions containing such a recombinant retrovirus are disclosed. Various methods for producing recombinant retroviruses having unique characteristics, and methods for producing transgenic packaging animals or insects are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 5, 1999
    Assignee: Chiron Corporation
    Inventors: Harry E. Gruber, Douglas J. Jolly, James G. Respess, Paul K. Laikind, Jack R. Barber, Daniel C. St. Louis, Sunil D. Chada, Stephen M. W. Chang, John F. Warner
  • HIV peptide-inducted T cell stimulation
    Patent number: 4943628
    Abstract: The present invention provides peptides derived from HIV-1 which are capable of stimulating T cell proliferation. Such peptides are useful for immunizing human subjects against HIV infection.
    Type: Grant
    Filed: June 13, 1988
    Date of Patent: July 24, 1990
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Jonathan I. Rosen, John F. Warner