Abstract: Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R5, G1, and G2 are defined herein.

Abstract: Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologs and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.

Abstract: Provided are processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a pharmaceutically acceptable salt thereof.

Abstract: Described is a device (410) for use in removing a conveyance member from a material. The device (410) includes a displacement element (412) for being placed at least partly around a conveyance member and for displacing material as the device is advanced along a conveyance member. The device (410) also includes a driven component for receiving a driving force for driving the device through material. The device can include a coupling element (418) for coupling the device to a shaft and a material loosener (414) including a drilling element. The material loosener can be operable to loosen material ahead of the displacement element as the device is advanced along a conveyance member. The drilling element can be coupled to a first wheel (436) and the coupling element can include a second wheel (434) cooperating with the first wheel to transfer rotational movement of a shaft to the drilling element.

Abstract: Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.

Abstract: Techniques for providing enhanced graphics in a user interface by efficiently using enhanced graphics resources. A computing device displays the enhanced graphics in an upper view of the user interface and the enhanced graphics resources identify a visual region in which the enhanced graphics are positioned. The computing device accesses the enhanced graphics resources to identify and store a hit test region based on the visual region. The hit test region is stored separately from the enhanced graphics resources for hit testing. When a hit is received in the user interface, the computing device determines whether the upper view or lower view will respond to the hit based on the hit test region that is stored separately from the enhanced graphics resources.

Abstract: There is provided an air spring for supporting a load, the air spring comprises a chamber for holding a pressurised gas in use, a load-bearing surface arranged to transmit a force from a load in use to the pressurised gas held in the chamber. Importantly, in order to lower the spring rate, the chamber contains a mass of adsorptive material. There is also provided a use of an adsorptive material for the purpose of lowering the spring rate of an air spring, including a gas strut and a pneumatic wheel. There is also provided a method of designing an air spring using an adsorptive material to lower the spring rate.

Abstract: A device for use in removing a conveyance member from a material includes a displacement element (12, 1012) and a self-propelling driving element. The displacement element (12, 1012) is for being placed at least partly around a conveyance member (16) and for displacing material as the displacement element (12, 1012) is advanced along a conveyance member (16). The driving element is coupled to and movable with the displacement element (12, 1012) to advance the displacement element along a conveyance member (16).

Abstract: Described is a device (410) for use in removing a conveyance member from a material. The device (410) includes a displacement element (412) for being placed at least partly around a conveyance member and for displacing material as the device is advanced along a conveyance member. The device (410) also includes a driven component for receiving a driving force for driving the device through material. The device can include a coupling element (418) for coupling the device to a shaft and a material loosener (414) including a drilling element. The material loosener can be operable to loosen material ahead of the displacement element as the device is advanced along a conveyance member. The drilling element can be coupled to a first wheel (436) and the coupling element can include a second wheel (434) cooperating with the first wheel to transfer rotational movement of a shaft to the drilling element.

Abstract: An on-demand vapour generator includes a vapour chamber configured to produce a vapour and a vapour absorption assembly configured to receive flows of vapour from the vapour chamber. The vapour absorption assembly includes a first vapour-permeable passage having a passage outlet and at least one second vapour-permeable passage that is closed. When vapour absorption assembly receives a flow of vapour front the vapour chamber, the flow of vapour passes through the first vapour-permeable passage to the passage outlet at least substantially without absorption of vapour from the flow of vapour. However, when a flow of vapour is not received from the vapour chamber, vapour entering the vapour absorption assembly from the vapour chamber passes into the first vapour-permeable passage and the at least one second vapour-permeable passage and is at least substantially absorbed.

Abstract: Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.

Abstract: There is provided an air spring for supporting a load, the air spring comprises a chamber for holding a pressurized gas in use, a load-bearing surface arranged to transmit a force from a load in use to the pressurized gas held in the chamber. Importantly, in order to lower the spring rate, the chamber contains a mass of adsorptive material. There is also provided a use of an adsorptive material for the purpose of lowering the spring rate of an air spring, including a gas strut and a pneumatic wheel. There is also provided a method of designing an air spring using an adsorptive material to lower the spring rate.

Abstract: Provided are processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, or a pharmaceutically acceptable salt thereof.

Abstract: Embodiments relate generally to methods, systems, devices and applications for use in relation to the detection of chemical vapours. A particular embodiment relates to a device for chemical vapour sensing. The device comprises a housing of a size to be manually portable, the housing defining a plurality of receptors adapted to receive a respective plurality of manually replaceable chemical vapour sensing components. The device further comprises at least one signal receiver to receive data signals from each chemical vapour sensing component when the chemical vapour sensing component is positioned in one of the receptors.

Abstract: A tray and cover for storing tubes, such as collapsible tubes. A tray is used to store and transport tubes, the tubes being similarly orientated and arranged side by side in parallel alignment and being held in position by opposing pairs of tray sidewalls. A tray may also be used with a cover.

Abstract: The method comprises depositing a coating of metal material on the inside surface of the body (4) of the stator (36), impregnating said coating with a self-lubricating composite material (20), machining internal cells (28) in the thickness of the coating (10), and machining orifices (34) leading into the cells.

Abstract: An on-demand vapor generator includes a vapor chamber configured to produce a vapor and a vapor absorption assembly configured to receive flows of vapor from the vapor chamber. The vapor absorption assembly includes a first vapor-permeable passage having a passage outlet and at least one second vapor-permeable passage that is closed. When vapor absorption assembly receives a flow of vapor from the vapor chamber, the flow of vapor passes through the first vapor-permeable passage to the passage outlet at least substantially without absorption of vapor from the flow of vapor. However, when a flow of vapor is not received from the vapor chamber, vapor entering the vapor absorption assembly from the vapor chamber passes into the first vapor-permeable passage and the at least one second vapor-permeable passage and is at least substantially absorbed.

Abstract: Various embodiments include apparatuses and systems for controlling compressor clearances. In one case, an apparatus includes: a material layer sized to fit a case of a gas turbine (GT) compressor in a GT system, the material layer including a heating element for applying heat to the case of the GT compressor; and a control system coupled with the material layer, the control system configured to: determine whether a shutdown sequence is occurring in the GT system; and actuate the heating element to apply heat to the case of the GT compressor in response to determining that the shutdown sequence is occurring.

Abstract: Guaranteeing space availability for thin devices includes reserving space without committing, or fully pre-allocating, the space to specific thin device ranges. Space may be held in reserve for a particular set of thin devices and consumed as needed by those thin devices. The system guards user-critical devices from running out of space, for example due to a “rogue device” scenario in which one device allocates an excessive amount of space. The system uses a reservation entity, to which a thin device may subscribe, which reserves space for the thin device without allocating that space before it is need to service an I/O request.

Abstract: Provided are processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoin-dolin-2-yl)piperidine-2,6-dione, or a pharmaceutically acceptable salt thereof.