Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.

Abstract: The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2? breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, R4, m, and n are defined herein.

Abstract: A storage port receives a login request. The storage port configures an audit mode indicator as enabled in a login response to a host port to enter a security enabled mode to indicate to the host port that Input/Output (I/O) operations are to be transmitted from the host port to the storage port even if authentication or security association negotiation with the storage port cannot be completed successfully.

Abstract: The present invention relates to an immunoassay for the detection of Borrelia specific IgG, IgM and IgG/IgM antibodies in biological samples suspected of Lyme infection. The immunoassay can be performed via a standard immunoassay format or on an automated platform. In various embodiments, the immunoassay uses one or more Borrelia specific chimeric peptides VlsE-FlaB (designated pFlaB-mV), VlsE-ErpP (designated pErp59-mV), VlsE-P35 (designated pP35-mV) alone or in combination with one or more outer surface protein C (Osp C) types B or I, p58 and DbpA. Other aspects of the invention provide antigen/substrate combinations and compositions comprising combinations of the disclosed peptides and/or proteins for use in the immunoassays described herein.

Abstract: A storage port receives a login request. The storage port configures an audit mode indicator as enabled in a login response to a host port to enter a security enabled mode to indicate to the host port that Input/Output (I/O) operations are to be transmitted from the host port to the storage port even if authentication or security association negotiation with the storage port cannot be completed successfully.

Abstract: The present application provides for compositions comprising high concentrations of acid a-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.

Abstract: The invention provides a material feed process for magnetically separating magnetic and non-magnetic particles from a material feed by means of a magnetic roller separator wherein the process is characterised therein that particle separation is independent of centrifugal force, and where the process can equally well be applied to both wet and dry particle separation. The process specifically provides feeding the particles at an incident zone above the horizontal axis centre line, and separating the magnetic and non-magnetic particles at opposite rotational sides of the roller.

Abstract: The present invention relates to an immunoassay for the detection of Borrelia specific IgG, IgM and IgG/IgM antibodies in biological samples suspected of Lyme infection. The immunoassay can be performed via a standard immunoassay format or on an automated platform. In various embodiments, the immunoassay uses one or more Borrelia specific chimeric peptides VlsE-FlaB (designated pFlaB-mV), VlsE-ErpP (designated pErp59-mV), VlsE-P35 (designated pP35-mV) alone or in combination with one or more outer surface protein C (Osp C) types B or I, p58 and DbpA. Other aspects of the invention provide antigen/substrate combinations and compositions comprising combinations of the disclosed peptides and/or proteins for use in the immunoassays described herein.

Abstract: Convolutional neural networks (CNNs) of a set of CNNs are evaluated using a test set of images (electron micrographs) associated with a selected particle type. A preferred CNN is selected based on the evaluation and used for processing electron micrographs of test samples. The test set of images can be obtained by manual selection or generated using a model of the selected particle type. Upon selection of images using the preferred CNN in processing additional electron micrographs, the selected images can be added to a training set or used as an additional training set to retrain the preferred CNN. In some examples, only selected layers of the preferred CNN are retrained. In other examples, two dimensional projections of based on particles of similar structure are used for CNN training or retraining.

Abstract: A path is secured from one node to another node of the computing environment. The one node obtains a first encryption key and a second encryption key. A shared key is obtained by the one node from a key server, and the shared key is used to encrypt a message. The encrypted message includes the first encryption key and the second encryption key. The encrypted message and an identifier of the shared key is sent from the one node to the other node, and a response message is received by the one node. The response message at least provides an indication that the other node received the encrypted message and obtained the shared key.

Abstract: The present invention provides methods to determine whether a patient with a lysosomal storage disorder will benefit from treatment with a specific pharmacological chaperone. The present invention exemplifies an in vitro method for determining ?-galactosidase A responsiveness to a pharmacological chaperone such as 1-deoxygalactonojirimycin in a cell line expressing a mutant from of ?-galactosidase A. The invention also provides a method for diagnosing Fabry disease in patients suspected of having Fabry disease.

Abstract: A path for a node of a computing environment is secured. The securing includes obtaining, by the node, a message that includes an identifier of a shared key and an encrypted message, the encrypted message including a first encryption key, a second encryption key, one or more first parameters and one or more second parameters. The node obtains the shared key from a key server and uses it to decrypt the encrypted message to obtain the first encryption key, the second encryption key, the one or more first parameters and the one or more second parameters. A second security parameters index, to be associated with the second encryption key and the one or more second parameters, is obtained. The node sends a response message to another node, the response message including the second security parameters index.

Abstract: Authentication is performed on a plurality of links to be used to couple one node of the computing environment and another node of the computing environment. The performing authentication includes obtaining, by the other node from the one node via one link of the plurality of links, an identifier of a shared key maintained by a key server. The other node uses the identifier to obtain the shared key from the key server. An indication that the other node decrypted a message received from the one node using the shared key is sent from the other node via the one link. The sending the indication on one or more other links of the plurality of links is repeated for subsequent messages decrypted by the other node using the shared key previously obtained.

Abstract: A path is secured from one node to another node of the computing environment. The one node obtains a first encryption key and one or more first parameters for transmission of data, and a second encryption key and one or more second parameters for reception of data. A shared key is obtained by the one node from a key server, and the shared key is used to encrypt a message. The encrypted message includes the first encryption key, the one or more first parameters, the second encryption key and the one or more second parameters. The encrypted message and an identifier of the shared key is sent from the one node to the other node, and a response message is received by the one node. The response message at least provides an indication that the other node received the encrypted message and obtained the shared key.

Abstract: Authentication is performed on a plurality of links coupling one node of the computing environment and another node of the computing environment. The performing authentication includes obtaining by the one node a shared key from a key server coupled to the one node and another node of the computing environment. A message encrypted with the shared key is sent from the one node to the other node via one link of the plurality of links. An indication that the other node decrypted the message using the shared key obtained by the other node is received from the other node via the one link. The sending and the receiving are repeated on one or more other links of the plurality of links using the shared key previously obtained.

Abstract: A path for a node of a computing environment is secured. The securing includes obtaining, by the node, a message that includes an identifier of a shared key and an encrypted message. The node obtains the shared key from a key server and uses it to decrypt the encrypted message to obtain an encryption key and one or more parameters. A security parameters index to be associated with the encryption key and the one or more parameters is obtained. The node sends a response message to another node, the response message including the security parameters index.

Abstract: Methods and systems for implementing artificial intelligence to determine the pose of a sample within a microscope system and aligning said sample are disclosed. An example method includes receiving an image of the sample in the microscope apparatus, accessing a template associated with the sample. The template describes a plurality of template key points of the template version of the sample. A plurality of key points on the sample are then determined, where each of the key points on the sample corresponds to a corresponding template key point of a sample template, and the key points are subsequently used to determine a transformation between the sample as depicted in the image and the template version of the sample as described in the template. The transformation can then be used to automate the alignment of the sample within the microscope.

Abstract: A storage port receives a login request. The storage port configures an audit mode indicator as enabled in a login response to a host port to enter a security enabled mode to indicate to the host port that Input/Output (I/O) operations are to be transmitted from the host port to the storage port even if authentication or security association negotiation with the storage port cannot be completed successfully.

Abstract: The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2? breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, R4, m, and n are defined herein.

Abstract: The present invention provides methods to determine whether a patient with a lysosomal storage disorder will benefit from treatment with a specific pharmacological chaperone. The present invention exemplifies an in vitro method for determining ?-galactosidase A responsiveness to a pharmacological chaperone such as 1-deoxygalactonojirimycin in a cell line expressing a mutant from of ?-galactosidase A. The invention also provides a method for diagnosing Fabry disease in patients suspected of having Fabry disease.