Patents by Inventor John H. Kenten

John H. Kenten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190257823
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Application
    Filed: May 2, 2019
    Publication date: August 22, 2019
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Publication number: 20160245799
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Application
    Filed: May 4, 2016
    Publication date: August 25, 2016
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Patent number: 9354230
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: May 31, 2016
    Assignee: MESO SCALE TECHNOLOGIES, LLC.
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Patent number: 8530408
    Abstract: The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: September 10, 2013
    Assignee: Meso Scale Technologies LLC
    Inventors: Ilia Davydov, John H. Kenten, Hans Biebuyck, Pankaj Oberoi
  • Patent number: 8450066
    Abstract: The invention comprises compositions and methods for determining the function of proteins. It advantageously uses cotransfection of a reporter gene to remove transfection efficiency as a factor affecting the success of cell based assays. This method links the activity of the gene product of interest to the expression of the reporter gene. In addition, it also allows for the development of assays that allow for rapid screening for protein function in cells and whole animals by using cloned genes in a high throughput assay format which is simple, fast and inexpensive.
    Type: Grant
    Filed: December 3, 2003
    Date of Patent: May 28, 2013
    Assignee: Meso Scale Technologies LLC
    Inventors: John H. Kenten, Douglas B. Woods
  • Publication number: 20110105354
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Application
    Filed: December 23, 2010
    Publication date: May 5, 2011
    Applicant: MESO SCALE TECHNOLOGIES, LLC
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Patent number: 7858321
    Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: December 28, 2010
    Assignee: Meso Scale Technologies, LLC
    Inventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
  • Publication number: 20100048485
    Abstract: The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
    Type: Application
    Filed: October 27, 2009
    Publication date: February 25, 2010
    Applicant: Meso Scale Technologies LLC
    Inventors: Ilia DAVYDOV, John H. Kenten, Hans Biebuyck, Pankaj Oberoi
  • Publication number: 20100048593
    Abstract: The present invention features 5-deazaflavin compounds, pharmaceutical compositions of 5-deazaflavin compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more 5-deazaflavin compounds of the invention.
    Type: Application
    Filed: February 23, 2009
    Publication date: February 25, 2010
    Applicants: Government of the US, as represented by the Secretary, Department of Health & Human Services, BioVeris Corporation
    Inventors: Allan M. Weissman, Karen H. Vousden, Jane P. Jensen, Yili Yang, Shengyun Fang, Douglas Woods, John H. Kenten, Ilia Davydov, Yassamin J. Safiran, Pankaj Oberoi
  • Patent number: 7662642
    Abstract: Disclosed are epitope-containing heat shock fusion proteins, DNA constructs encoding such fusion proteins, and methods of use. More specifically, disclosed are ubiquitin fusion proteins comprising ubiquitin fused to a plurality of identical or non-identical epitopes at specified locations.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: February 16, 2010
    Assignee: Wellstat BioCatalysis, LLC
    Inventors: John H. Kenten, Alfonso Tramontano, Aprile L. Pilon, Gerald L. Lohnas, Steven F. Roberts
  • Patent number: 7608682
    Abstract: The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.
    Type: Grant
    Filed: October 28, 2003
    Date of Patent: October 27, 2009
    Assignee: Meso Scale Technologies LLC
    Inventors: Ilia Davydov, John H. Kenten, Hans Biebuyck, Pankaj Oberoi
  • Patent number: 7498336
    Abstract: The present invention features 5-deazaflavin compounds, pharmaceutical compositions of 5-deazaflavin compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more 5-deazaflavin compounds of the invention.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: March 3, 2009
    Assignees: The United States of America as represented by the Secretary, Department of Health and Human Services, BioVeris Corporation
    Inventors: Allan M. Weissman, Karen H. Vousden, Jane P. Jensen, Yili Yang, Shengyun Fang, Douglas Woods, John H. Kenten, Ilia Davydov, Yassamin J. Safiran, Pankaj Oberoi
  • Publication number: 20090042193
    Abstract: Processes for measuring DNA or RNA binding proteins, specific nucleic acids, as well as enzyme activities using labeled nucleic acids of labeled protein/peptide molecules are provided.
    Type: Application
    Filed: October 31, 2007
    Publication date: February 12, 2009
    Inventors: Jeffrey A. Heroux, Maura C. Kibbey, John H. Kenten
  • Patent number: 7462322
    Abstract: An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a sample containing volume intersecting with inlet and outlet means, an electrode having a substantially horizontally positioned surface exposed to and positioned below a portion of the sample containing volume, means for impressing electrochemical energy upon said electrode sufficient to generate luminescence, means for magnetically collecting particles along said surface and means for measuring the luminescence generated at said electrode.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: December 9, 2008
    Assignee: Bioveris Corporation
    Inventors: John K. Leland, Haresh P. Shah, John H. Kenten, Jack E. Goodman, George E. Lowke, Yuzaburo Namba, Gary F. Blackburn, Richard J. Massey
  • Patent number: 7439017
    Abstract: The present invention provides processes for measuring DNA or RNA binding proteins, specific nucleic acids, as well as enzyme activities using labeled nucleic acids of labeled protein/peptide molecules.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: October 21, 2008
    Assignee: BioVeris Corporation
    Inventors: Jeffrey A. Heroux, Maura C. Kibbey, John H. Kenten
  • Publication number: 20080254465
    Abstract: Processes for measuring DNA or RNA binding proteins, specific nucleic acids, as well as enzyme activities using labeled nucleic acids of labeled protein/peptide molecules are provided.
    Type: Application
    Filed: October 31, 2007
    Publication date: October 16, 2008
    Inventors: Jeffrey A. Heroux, Maura C. Kibbey, John H. Kenten
  • Publication number: 20080254494
    Abstract: Processes for measuring DNA or RNA binding proteins, specific nucleic acids, as well as enzyme activities using labeled nucleic acids of labeled protein/peptide molecules are provided.
    Type: Application
    Filed: October 31, 2007
    Publication date: October 16, 2008
    Inventors: Jeffrey A. Heroux, Maura C. Kibbey, John H. Kenten
  • Patent number: 7273920
    Abstract: The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for the treatment of disease such as infections, inflammatory conditions, cancer and genetic diseases. The compounds are also useful as insecticides and herbicides.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: September 25, 2007
    Assignee: Wellstat BioCatalysis, LLC
    Inventors: John H. Kenten, Steven F. Roberts
  • Patent number: 7074620
    Abstract: Method for reducing the level and/or activity of a target protein in a eukaryotic cell via activation of ubiquitination of the target protein wherein the cell is contacted with the compound having a ubiquitination recognition element covalently linked to a target protein binding element. The ubiquitination and recognition element can bind to either the E3 or E2 elements of the ubiquitination system and the target protein binding element is able to bind specifically to the target protein. The target protein binding element has a molecular weight of less than 30,000 and has a binding affinity for the target protein greater than 105M31 1.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: July 11, 2006
    Assignee: Proteinix, Inc.
    Inventors: John H. Kenten, Steven F. Roberts
  • Patent number: 7063946
    Abstract: Apparatus, systems, system components, methods, compositions, and reagents for determining the function and activity of peptides and proteins and for identifying and characterizing molecules that affect these functions and activities. More specifically, methods and reagents used to determine the various activities of peptides and proteins including their binding specificity, binding activity, their enzymatic activity and their ability to act as substrates for enzymes. The disclosed methods are especially suited for the analysis of peptide and protein function where large numbers of peptides and proteins need to be analyzed.
    Type: Grant
    Filed: September 10, 2002
    Date of Patent: June 20, 2006
    Assignee: Meso Scale Technologies, LLC.
    Inventors: John H. Kenten, Hans Biebuyck, Ilia Davydov, Nisar Pampori, Steven Yan Cheng, Stefanie Nelson