Patents by Inventor John Hartley

John Hartley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10937623
    Abstract: A deflector for multiple electron beams includes a first electrode substrate, second to fourth electrode substrates disposed in order in parallel to each other in a first same plane which is orthogonal to the substrate surface of the first electrode substrate, a fifth electrode substrate disposed opposite to the first electrode substrate, and sixth to eighth electrode substrates disposed in order in parallel to each other in a second same plane such that they are opposite to the second to fourth electrode substrates, wherein the first to eighth electrode substrates are disposed such that they surround a space through which multiple electron beams pass.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: March 2, 2021
    Assignees: NuFlare Technology, Inc., NuFlare Technology America, Inc.
    Inventor: John Hartley
  • Publication number: 20200405879
    Abstract: The present disclosure relates to combination therapies for the treatment of pathological conditions, such as cancer. In particular, the present disclosure relates to combination therapies comprising treatment with an Antibody Drug Conjugate (ADC), a secondary agent, and optionally an anti-CD20 agent. The Antibody Drug Conjugates target CD19 or CD22 and are disclosed for the treatment of cancers. Methods for identifying an individual as suitable for treatment by selecting patient if he/she is or has been treated with an anti-CD20 agent such as rituximab are disclosed. Optionally, the ADC is administered in combination with a further agent, e.g. a chemotherapeutic agent.
    Type: Application
    Filed: April 20, 2018
    Publication date: December 31, 2020
    Inventors: Jay Marshall Feingold, Patricius Hendrikus Cornelis Van Berkel, Jens Wuerthner, John Hartley, Francesca Zammarchi
  • Publication number: 20200399220
    Abstract: 3,5-Diarylidenyl-N-substituted-piperid-4-one analogs, and pharmaceutically acceptable derivatives thereof, are useful in the treatment or prevention of disorders including cancer, autoimmune disorders, inflammatory disorders, and fibrotic disorders. The compounds are included in pharmaceutical compositions, and are useful for treating disorders, such as cancer associated with aberrant Stat3 pathway activity. The compositions further include another therapeutic agent, such as an anticancer drug. Such compounds or compositions thereof are used to treat resistant and/or metastatic cancers. Methods also inhibit Stat3 pathway activity in a cell. Other methods are useful for making the pharmaceutical compounds. Synthetic methods are also useful for making the compounds. The compounds and compositions are useful as a fluorescent probe.
    Type: Application
    Filed: May 19, 2020
    Publication date: December 24, 2020
    Inventors: Konstantinos Kiakos, John A. Hartley, Moses Namfong Lee
  • Publication number: 20200367961
    Abstract: Systems and methods for treating acne including an apparatus that applies or a method involving applying targeted energy to disrupt or destroy sebocyte progenitor cells within a target sebaceous gland. In one approach, specific sebocyte receptors are targeted to facilitate disrupting and/or destroying targeted sebocytes.
    Type: Application
    Filed: August 13, 2020
    Publication date: November 26, 2020
    Inventors: Jonathan Podmore, Joshua Makower, Earl Bright II, Bryan Hartley, John Hanley
  • Publication number: 20200334001
    Abstract: A standalone DJ console includes onboard audio data, user interface, processing engine and mixing module that enable multiple virtual audio players operating under the control of the processor to be mixed by virtual mixing processes into two different audio signal streams routable to different outputs of the console to provide two different audio streams to two separate spaces. The user interface is designed with a virtual display and parallel sets of controls which enable virtual representations of audio waveforms to be scrolled relative to an axis of time above the respective set of controllers used to manipulate the audio signal stream.
    Type: Application
    Filed: December 12, 2019
    Publication date: October 22, 2020
    Applicant: inMusic Brands, Inc.
    Inventors: John O'Donnell, John Souppa, Ross Hartley Goodwin, Christopher Blane Roman, Jason William Stout
  • Patent number: 10799427
    Abstract: There is disclosed a drinking receptacle comprising: a container for containing a fluid for drinking; and an outlet member having an outlet through which the fluid is delivered under a pressure supplied by a user of the receptacle and a collar portion that attaches to an opening of the container such that an undersurface of the collar portion abuts with an upper surface of the opening of the container to form a substantially sealed engagement between the outlet member and the container; wherein either the undersurface of the collar portion or the upper surface of the opening of the container has at least one vent formed therein, the at least one vent being configured such that when said pressure is applied to the outlet member the at least one vent member permits the controlled ingress of air into the container to facilitate flow of fluid from the outlet, and when said pressure is removed the at least one vent member substantially prevents the ingress of air into the container to facilitate a controlled vacuu
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: October 13, 2020
    Assignee: Sepal IP Pty Ltd.
    Inventors: Callum MacLeod, Toby Hartley, Mark Turner, John Petschel, Justin Armistead, George Kotsiopoulos, Diana Tomoiaga
  • Patent number: 10780096
    Abstract: The present disclosure relates to the use of antibody-drug conjugates (ADCs) comprising pyrrolobenzodiazepine (PBD) dimers and anti-CD25 antibodies for use in treating disorders characterized by the presence of CD25+ve cells.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: September 22, 2020
    Assignees: ADC THERAPEUTICS SA, MEDIMMUNE LIMITED
    Inventors: Patricius Henrikus Cornelis Van Berkel, Philip Wilson Howard, John Hartley
  • Publication number: 20200286704
    Abstract: A multiple electron beam irradiation apparatus includes a forming mechanism which forms multiple primary electron beams; a plurality of electrode substrates being stacked in each of which a plurality of openings of various diameter dimensions are formed, the plurality of openings being arranged at passage positions of the multiple primary electron beams, and through each of which a corresponding one of the multiple primary electron beams passes, the plurality of electrode substrates being able to adjust an image plane conjugate position of each of the multiple primary electron beams depending on a corresponding one of the various diameter dimensions; and a stage which is capable of mounting thereon a target object to be irradiated with the multiple primary electron beams having passed through the plurality of electrode substrates.
    Type: Application
    Filed: March 5, 2020
    Publication date: September 10, 2020
    Applicants: NuFlare Technology, Inc, NuFlare Technology America, Inc
    Inventors: Kazuhiko INOUE, Atsushi Ando, Munehiro Ogasawara, John Hartley
  • Patent number: 10734190
    Abstract: A multiple electron beam irradiation apparatus includes an electromagnetic lens configured to refract multiple electron beams incident, an aberration corrector arranged in the magnetic field of the electromagnetic lens and configured to be able to individually apply a bias potential and a deflection potential to each of the multiple electron beams, and an objective lens configured to focus the multiple electron beams, a trajectory of the each of which has been individually corrected by the bias potential and the deflection potential, onto a target object.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: August 4, 2020
    Assignees: NuFlare Technology, Inc., NuFlare Technology America, Inc.
    Inventors: Atsushi Ando, Munehiro Ogasawara, Riki Ogawa, John Hartley
  • Publication number: 20200211812
    Abstract: A multiple electron beam irradiation apparatus includes a shaping aperture array substrate to form multiple primary electron beams, a plurality of electrode array substrates stacked each to dispose thereon a plurality of electrodes each arranged at a passage position of each of the multiple primary electron beams, each of the multiple primary electron beams surrounded by an electrode of the plurality of electrodes when each of the multiple primary electron beams passes through the passage position, the first wiring and the second wiring applied with one of different electric potentials, and a stage to mount thereon a target object to be irradiated with the multiple primary electron beams having passed through the plurality of electrode array substrates, wherein, in each of the plurality of electrode array substrates, each of the plurality of electrodes is electrically connected to either one of the first wiring and the second wiring.
    Type: Application
    Filed: December 23, 2019
    Publication date: July 2, 2020
    Applicants: NuFlare Technology, Inc., NuFlare Technology America, Inc.
    Inventors: Kazuhiko INOUE, Atsushi Ando, Munehiro Ogasawara, John Hartley
  • Publication number: 20200187709
    Abstract: A cooking apparatus has a user interface for selecting a cooking preference, a measurement sensor for measuring a distance between a pair of plates when a food item lies between the pair of plates, a weight sensor for measuring weight of the food item, and a control system for receiving at least one signal from the measurement and weight sensors to determine a cooking profile for cooking the food item to the cooking preference and to calculate a total amount of energy required to cook the food item according to the cooking profile and an amount of energy to be transferred per unit time to the food item, and to control power supply to the heating element based on the calculated amount of energy transferred per unit time to the food item.
    Type: Application
    Filed: November 22, 2019
    Publication date: June 18, 2020
    Inventors: David AYRE, Callum MACLEOD, George KOTSIOPOULOS, Toby HARTLEY, John PETSCHEL
  • Publication number: 20200129637
    Abstract: The present disclosure relates to combination therapies for the treatment of pathological conditions, such as cancer. In particular, the present disclosure relates to combination therapies comprising treatment with an Antibody Drug Conjugate (ADC) and a secondary agent.
    Type: Application
    Filed: April 20, 2018
    Publication date: April 30, 2020
    Inventors: Patricius Hendrikus Cornelis Van Berkel, Jens Wuerthner, John Hartley, Francesca Zammarchi
  • Publication number: 20200129638
    Abstract: The present disclosure relates to combination therapies for the treatment of pathological conditions, such as cancer. In particular, the present disclosure relates to combination therapies comprising treatment with an Antibody Drug Conjugate (ADC) and a secondary agent.
    Type: Application
    Filed: April 20, 2018
    Publication date: April 30, 2020
    Inventors: Patricius Hendrikus Cornelis Van Berkel, Jens Wuerthner, John Hartley, Francesca Zammarchi
  • Publication number: 20200057599
    Abstract: Systems and methods for selecting an audio track by performing a gesture on a track-list image are provided. The system includes a processor that performs a method including displaying the audio-track list, detecting a contact with the touchscreen display at a location corresponding to the audio track, detecting a continuous movement of the contact in a direction, detecting a length of the continuous movement, and selecting the audio track if the continuous movement has a length longer than a threshold length. The method includes shifting text associated with the audio track based on the length and direction of the continuous movement. The method includes determining that the selection is a command to queue the audio track for playback or add it to a preparation track list. This determination may be based on the direction of the continuous movement.
    Type: Application
    Filed: January 5, 2018
    Publication date: February 20, 2020
    Applicant: inMusic Brands, Inc.
    Inventors: John O'DONNELL, Ross Hartley GOODWIN, Lindsey Ryan COLE, Jason William STOUT, Vincent Ming CHEN, Marcus TILLMANS
  • Publication number: 20200043698
    Abstract: An electron optical system includes an electromagnetic lens configured to include a yoke, and refract an electron beam passing through the yoke by generating a magnetic field, and a shield coil disposed along the inner wall of the yoke, and configured to reduce a leakage magnetic field generated by the electromagnetic lens.
    Type: Application
    Filed: July 30, 2019
    Publication date: February 6, 2020
    Applicants: NuFlare Technology, Inc., NuFlare Technology America, Inc.
    Inventor: John HARTLEY
  • Patent number: 10544223
    Abstract: The present disclosure relates to combination therapies for the treatment of pathological conditions, such as cancer. In particular, the present disclosure relates to combination therapies comprising treatment with an Antibody Drug Conjugate (ADC) and a secondary agent.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: January 28, 2020
    Assignees: ADC THERAPEUTICS SA, MEDIMMUNE LIMTIED
    Inventors: Patricius Hendrikus Cornelis Van Berkel, Jens Wuerthner, John Hartley, Francesca Zammarchi
  • Patent number: 10517426
    Abstract: A cooking apparatus includes a pair of plates in between which a food item is to be cooked, at least one of the plates having a heating element for cooking the food item. The cooking apparatus has a user interface for selecting a cooking preference, a measurement sensor for measuring a distance between the pair of plates when the food item lies between the pair of plates, a weight sensor for measuring weight of the food item, and a control system for receiving at least one signal from the measurement and weight sensors to determine a cooking profile for cooking the food item to the cooking preference and to calculate a total amount of energy required to cook the food item according to the cooking profile and an amount of energy to be transferred per unit time to the food item, and to control power supply to the heating element based on the calculated amount of energy transferred per unit time to the food item.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: December 31, 2019
    Assignee: EASYGRILL PTY LTD
    Inventors: David Ayre, Callum Macleod, George Kotsiopoulos, Toby Hartley, John Petschel
  • Publication number: 20190391785
    Abstract: Systems and methods for generating a graphical representation of audio signal data during time compression or expansion are provided. The system may include a processor that performs a method including displaying a waveform during audio-signal playback at a first speed by scrolling the waveform from aright portion of a display to a left portion of the display. The method includes receiving a command to increase or decrease the audio-signal playback speed and horizontally expanding or horizontally contracting the waveform in response to receiving the command to increase or decrease the audio-signal playback speed.
    Type: Application
    Filed: January 5, 2018
    Publication date: December 26, 2019
    Applicant: inMusic Brands, Inc.
    Inventors: John O'DONNELL, Ross Hartley GOODWIN, Vincent Ming CHEN, Marcus TILLMANS
  • Publication number: 20190378676
    Abstract: A deflector for multiple electron beams includes a first electrode substrate, second to fourth electrode substrates disposed in order in parallel to each other in a first same plane which is orthogonal to the substrate surface of the first electrode substrate, a fifth electrode substrate disposed opposite to the first electrode substrate, and sixth to eighth electrode substrates disposed in order in parallel to each other in a second same plane such that they are opposite to the second to fourth electrode substrates, wherein the first to eighth electrode substrates are disposed such that they surround a space through which multiple electron beams pass.
    Type: Application
    Filed: May 22, 2019
    Publication date: December 12, 2019
    Applicants: NuFlare Technology, Inc., NuFlare Technology America, Inc.
    Inventor: John Hartley
  • Patent number: 10493259
    Abstract: This disclosure describes embodiments of a kit and its constituent components which together form an apparatus in which fluid communication between a medical device's lumen and the surrounding environment is provided by a conduit cooperatively defined by the medical device and a tubular member into which the device is inserted. The medical device and tubular member are configured to fit together such that an outer surface of the distal region of the medical device cooperates with an inner surface of the tubular member to define the conduit between the side-port of the medical device and a distal end of the tubular member. The conduit is operable to be used for injecting fluid, withdrawing fluid, and measuring pressure, for example. Methods of assembling and using the apparatus are described as well.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: December 3, 2019
    Assignee: Baylis Medical Company Inc.
    Inventors: John Paul Urbanski, Krishan Shah, Gareth Davies, Mahmood Mirza, Naheed Visram, Amanda Hartley