Patents by Inventor John J. Baldwin

John J. Baldwin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4736064
    Abstract: Prodrugs of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formula (I): ##STR1## and pharmaceutically acceptable salts thereof are disclosed.
    Type: Grant
    Filed: September 29, 1986
    Date of Patent: April 5, 1988
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Wasyl Halczenko, George Hartman
  • Patent number: 4710504
    Abstract: Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective .alpha..sub.2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, platelet aggregation inhibitors, antiobesity agents, and modifiers of gastrointestinal motility.
    Type: Grant
    Filed: April 4, 1986
    Date of Patent: December 1, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Joel R. Huff, Joseph P. Vacca, Steven D. Young, Jane deSolms, James P. Guare, Jr.
  • Patent number: 4690928
    Abstract: Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective .alpha..sub.6 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, antidiabetics, antiobesity and platelet aggregation inhibitors.
    Type: Grant
    Filed: July 14, 1986
    Date of Patent: September 1, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Joel R. Huff, Joseph P. Vacca, John J. Baldwin
  • Patent number: 4686222
    Abstract: Heterocyclic aminoethanols of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere het is a 6-10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: August 11, 1987
    Assignees: Merck & Co., Inc., Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Patent number: 4686226
    Abstract: Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective .alpha..sub.2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, antiobesity and platelet aggregation inhibitors and modifiers of gastrointestinal motility.
    Type: Grant
    Filed: September 3, 1985
    Date of Patent: August 11, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Joel R. Huff, John J. Baldwin, Yojiro Sakurai, Joseph P. Vacca, James P. Guare, Jr.
  • Patent number: 4678806
    Abstract: Prodrugs of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formula (I): ##STR1## the amido ester moiety of which is in the L-configuration, and pharmaceutically acceptable salts thereof are disclosed.
    Type: Grant
    Filed: September 2, 1986
    Date of Patent: July 7, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Wasyl Halczenko, George Hartman, Steven M. Pitzenberger
  • Patent number: 4677102
    Abstract: There are disclosed novel diazapines and derivatives thereof which are useful in the treatment of cardiovascular disorders.
    Type: Grant
    Filed: February 7, 1986
    Date of Patent: June 30, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure, David A. Claremon
  • Patent number: 4677115
    Abstract: Aromatic sulfonamides with a saturated heterocycle fused thereto are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure.
    Type: Grant
    Filed: May 14, 1986
    Date of Patent: June 30, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Marcia E. Christy, Gerald S. Ponticello
  • Patent number: 4675321
    Abstract: Pharmaceutical compositions of specific substituted pyrimidines and methods of treatment of certain cardiovascular disorders are disclosed. Also disclosed are novel substituted acrylated pyrimidines which are useful as calcium channel blockers.
    Type: Grant
    Filed: February 7, 1986
    Date of Patent: June 23, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Steven M. Pitzenberger, David E. McClure
  • Patent number: 4665094
    Abstract: Hydroxyalkyl-phenoxy-propan-2-olamines and novel esters thereof are oculoselective .beta.-blockers useful in the treatment of elevated intraocular pressure with little or no effect on the pulmonary or cardiovascular system.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: May 12, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Patent number: 4656188
    Abstract: Angiotensin converting enzyme inhibitors are useful in the treatment of senile macular degeneration.
    Type: Grant
    Filed: October 9, 1985
    Date of Patent: April 7, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Daniel F. Veber, John J. Baldwin
  • Patent number: 4656168
    Abstract: Compounds of the formula Het-O-CH.sub.2 -CHOR-CH.sub.2 -NHaralkyl where Het is a 10 membered N-containing ring are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: October 13, 1983
    Date of Patent: April 7, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Patent number: 4642311
    Abstract: Substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: February 10, 1987
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Patent number: 4616017
    Abstract: Novel tertiary aminohydroxypropoxy substituted aryl compounds exhibit .alpha..sub.1 -adrenoceptor and serotonin antagonism and are also useful as antihypertensive agents.
    Type: Grant
    Filed: June 4, 1984
    Date of Patent: October 7, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Patent number: 4609494
    Abstract: Novel substituted and bridged pyrimidine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed.
    Type: Grant
    Filed: February 21, 1985
    Date of Patent: September 2, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David A. Claremon, David E. McClure
  • Patent number: 4602093
    Abstract: Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit cardioselective .beta.-adrenergic blocking activity, and are useful as antihypertensive agents, cardioprotective agents, antiarrythmic agents, antianginal agents with reduced side effects; e.g., they are devoid of intrinsic sympathomimetic activity.
    Type: Grant
    Filed: February 8, 1984
    Date of Patent: July 22, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello, Marcia E. Christy
  • Patent number: 4593039
    Abstract: 1-Aryloxy-3-(substituted aminoalkylamino)-2-propanols and pharmaceutically acceptable salts thereof have .beta.-adrenergic blocking activity with some cardioselectivity and hence are useful as antihypertensive, antianginal, antiarrhythmic and cardioprotective agents and in the treatment of elevated intraocular pressure such as glaucoma.
    Type: Grant
    Filed: April 2, 1984
    Date of Patent: June 3, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Sandor L. Varga, Gerald S. Ponticello
  • Patent number: 4588824
    Abstract: Processes for preparing (S) or (R) epihalohydrin and an (S) substituted glycerol intermediate are disclosed.
    Type: Grant
    Filed: June 16, 1983
    Date of Patent: May 13, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • Patent number: 4574127
    Abstract: Novel substituted aminohydroxypropoxyphenyl oxazole and thiazole compounds and methods for their preparation are disclosed. These compounds, and their salts exhibit cardioselective .beta.-adrenergic blocking activity, and are useful as antihypertensive, cardioprotective, antiarrhythmic and antianginal agents.
    Type: Grant
    Filed: May 7, 1984
    Date of Patent: March 4, 1986
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Patent number: 4568679
    Abstract: Heterocyclic aminoethanols of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere het is a 6-10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals for reducing intraocular pressure, for use as .alpha.- and .beta.-and adrenergic blocking agents, as antihypertensive agents and for effecting bronchodilation.
    Type: Grant
    Filed: March 25, 1982
    Date of Patent: February 4, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure