Patents by Inventor John J. Baldwin

John J. Baldwin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6316443
    Abstract: Combinations of a &bgr;-adrenergic antagonist and a topical carbonic anhydrase inhibitor are particularly useful in the treatment of ocular hypertension, especially in patients insufficiently responsive to treatment with &bgr;-adrenergic antagonists.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: November 13, 2001
    Assignee: Merck & Co., Inc.
    Inventor: John J. Baldwin
  • Patent number: 6248735
    Abstract: Combinations of a &bgr;-adrenergic antagonist and a topical carbonic anhydrase inhibitor are particularly useful in the treatment of ocular hypertension, especially in patients insufficiently responsive to treatment with &bgr;-adrenergic antagonists.
    Type: Grant
    Filed: April 3, 1997
    Date of Patent: June 19, 2001
    Assignee: Merck & Co., Inc.
    Inventor: John J. Baldwin
  • Patent number: 6214827
    Abstract: Novel compounds of Formula are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
    Type: Grant
    Filed: June 23, 1998
    Date of Patent: April 10, 2001
    Assignee: Schering Corporation
    Inventors: Adriano Afonso, John J. Baldwin, Ronald J. Doll, Ge Li, Alan K. Mallams, F. George Njoroge, Dinanath F. Rane, John C. Reader, Randall R. Rossman
  • Patent number: 6017768
    Abstract: Combinatorial libraries are disclosed which are represented by Formula I: ##STR1## wherein: ##STR2## is a solid support; T'--L-- is an identifier residue; and --L'--II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula ##STR3## which interact (i.e., as agonists or antagonists) with .alpha. adrenergic receptors, dopamine receptors, .sigma.-opiate receptors, and K.sup.+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatment of ocular diseases such as glaucoma.
    Type: Grant
    Filed: October 18, 1996
    Date of Patent: January 25, 2000
    Assignee: Pharmacopeia, Inc.
    Inventors: John J. Baldwin, John C. Reader, Lawrence W. Dillard, Ge Li, Wenguang Zeng
  • Patent number: 5965570
    Abstract: Novel tricyclic compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
    Type: Grant
    Filed: September 11, 1997
    Date of Patent: October 12, 1999
    Assignees: Schering Corporation, Pharmacopeia Inc.
    Inventors: Alan B. Cooper, Alan K. Mallams, Viyyoor M. Girijavallabhan, Ronald J. Doll, Arthur G. Taveras, F. George Njoroge, John J. Baldwin, John C. Reader
  • Patent number: 5880128
    Abstract: Novel carbonyl piperazinyl and piperidinyl compounds and pharmaceutical compositions are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel carbonyl piperazinyl or piperidinyl compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: March 9, 1999
    Assignees: Schering Corporation, Pharmacopeia Inc.
    Inventors: Ronald J. Doll, Alan K. Mallams, Adriano Afonso, Dinanth F. Rane, George F. Njoroge, Randall R. Rossman, John J. Baldwin, Ge Li, John C. Reader
  • Patent number: 5821241
    Abstract: Compounds of the invention have the formula ##STR1## The compounds have fibrinogen receptor antagonist activity.
    Type: Grant
    Filed: August 1, 1995
    Date of Patent: October 13, 1998
    Assignee: Merck & Co., Inc.
    Inventors: David Alan Claremon, John J. Baldwin, Nigel Liverton, Ben Askew
  • Patent number: 5821130
    Abstract: Combinatorial libraries are disclosed which are represented by Formula I:(T'--L).sub.q --S--C(O)--L'--II' Iwherein:S is a solid support; T'--L-- is an identifier residue; and --L'--II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula: ##STR1## which interact (i.e., as agonists or antagonists) with .alpha. adrenergic receptors, dopamine receptors, .sigma.-opiate receptors, and K.sup.+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatment of ocular diseases such as glaucoma.
    Type: Grant
    Filed: November 3, 1995
    Date of Patent: October 13, 1998
    Assignee: Pharmacopeia, Inc.
    Inventors: John J. Baldwin, John C. Reader, Lawrence W. Dillard, Ge Li, Wenguang Zeng
  • Patent number: 5801175
    Abstract: Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: September 1, 1998
    Assignees: Schering Corporation, Pharmacopeia, Inc.
    Inventors: Adriano Afonso, John J. Baldwin, Ronald J. Doll, Ge Li, Alan K. Mallams, F. George Njoroge, Dinanath F. Rane, John C. Reader, Randall R. Rossman
  • Patent number: 5766963
    Abstract: A combinatorial library is disclosed which is represented by Formula ##STR1## wherein: ##STR2## is a solid support; T'-L- is an identifier residue; and -L'-II' is a ligand/linker residue. This library contains hydroxypropylamines of the formula:Aa.sup.1 -Aa.sup.2 -(CH.sub.2 Ar.sup.1)-CH.sub.2 CHOH-CH.sub.2 XR.sup.1IIwherein:Aa.sup.1 and Aa.sup.2 is each an amino acid joined to each other through an amide bond;Ar.sup.1 is an aromatic ring system;--CH.sub.2 Ar.sup.1 is attached to N on Aa.sup.2 ; andR.sup.1 is H, C.sub.1-20 alkyl, alkenyl, alkynyl, aryl, heteroaryl, aryl or heteroaryl fused to a 3- or 4-membered moiety to form a non-aromatic second ring, or substituted C.sub.1-20 alkyl, alkenyl, or alkynyl.
    Type: Grant
    Filed: January 26, 1996
    Date of Patent: June 16, 1998
    Assignee: Pharmacopeia, Inc.
    Inventors: John J. Baldwin, Ian Henderson, Frank S. Waksmunski
  • Patent number: 5756810
    Abstract: A process for preparing t-butyl 4-(hydroxymethyl)-3-nitrobenzoate from t-butyl 4-(acetoxymethyl)-3-nitrobenzoate which comprises reacting t-butyl 4-(acetoxymethyl)-3-nitrobenzoate with hydrazine or hydrazine hydrate in a lower alkanol at 0.degree.-50.degree. C.
    Type: Grant
    Filed: September 11, 1996
    Date of Patent: May 26, 1998
    Assignee: Pharmacopeia, Inc.
    Inventors: John J. Baldwin, Michael H. J. Ohlmeyer, Ian Henderson
  • Patent number: 5698566
    Abstract: A series of novel spirocycles of general structural formula: ##STR1## or a pharmaceutically acceptable salt, hydrate or crystal form thereof are presented, whereinR.sup.1 =H.sub.3 CSO.sub.2 NH--, H.sub.3 CO--, alkylSO.sub.2 --, alkylCONH--, NO.sub.2 --;R.sup.2 =H, --OCH.sub.3 ;R.sup.3 and R.sup.4 taken together are .dbd.O, or R.sup.3 is H and R.sup.4 is OH;R.sup.5 =R.sup.6 taken together are --CH.sub.2 --CH.sub.2 --, .dbd.CH.sub.2 ;R.sup.7 is ##STR2## which are Class III antiarrhythmic agents and positive inotropic or cardiotonic agents.
    Type: Grant
    Filed: November 2, 1995
    Date of Patent: December 16, 1997
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David A. Claremon, Jason M. Elliott, Gerald S. Ponticello, David C. Remy, Harold G. Selnick
  • Patent number: 5696111
    Abstract: This invention is concerned with novel compounds represented by structural formula I and II. ##STR1## which are antiarrhythmic agents.
    Type: Grant
    Filed: May 16, 1996
    Date of Patent: December 9, 1997
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David A. Claremon, Nigel Liverton, Harold G. Selnick
  • Patent number: 5688997
    Abstract: Combinatorial libraries are disclosed which are represented by Formula I:(T'-L).sub.q -S-C(O)-L'-II' Iwherein:S is a solid support; T'-L- is an identifier residue; and -L'-II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula: ##STR1## which interact (i.e., as agonists or antagonists) with .alpha. adrenergic receptors, dopamine receptors, .sigma.-opiate receptors, and K.sup.+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatment of ocular diseases such as glaucoma.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 18, 1997
    Assignee: Pharmacopeia, Inc.
    Inventors: John J. Baldwin, John C. Reader, Lawrence W. Dillard, Ge Li, Jonathan J. Burbaum, Wenguang Zeng
  • Patent number: 5679672
    Abstract: Compounds of structures (I) and (Ia) are Class III antiarrhythmic agents ##STR1##
    Type: Grant
    Filed: May 14, 1996
    Date of Patent: October 21, 1997
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David A. Claremon, Jason M. Elliott, Nigel Liverton, David C. Remy, Harold G. Selnick
  • Patent number: 5663046
    Abstract: Directly dividing the contents of each sub-pool into the sub-pools for the next step in the synthetic scheme for producing a combinatorial library reduces the standard deviation, .sigma., relative to the standard deviation of the split synthesis method for producing such libraries.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: September 2, 1997
    Assignee: Pharmacopeia, Inc.
    Inventors: John J. Baldwin, Eric G. Horlbeck
  • Patent number: 5633247
    Abstract: Spirocycles of general structural formula: ##STR1## are Class III antiarrhythmic agents.
    Type: Grant
    Filed: July 5, 1995
    Date of Patent: May 27, 1997
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David A. Claremon, Jason M. Elliott, Gerald S. Ponticello, David C. Remy, Harold G. Selnick
  • Patent number: 5618830
    Abstract: Dioxobutanoic acids substituted with piperidine or similar N-substituted saturated cycloalkyls are found to inhibit the cap-dependent endonuclease of influenza virus. These compounds are useful in the prevention or treatment of infection by influenza virus and the treatment of influenza, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating influenza and methods of preventing or treating infection by influenza virus are also described.
    Type: Grant
    Filed: September 29, 1995
    Date of Patent: April 8, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Harold G. Selnick, John J. Baldwin, Gerald S. Ponticello, Joanne E. Tomassini
  • Patent number: 5618825
    Abstract: Combinatorial libraries are disclosed which are represented by Formula I:(T'--L).sub.q -- S--C(O)--L'--II' Iwherein:S is a solid support; T'--L-- is an identifier residue; and --L'--II' is a ligand/linker residue. Compounds which contain aryl sulfonamides, N-acyl derivatives, and N-substituted pyrrolidines and piperidines of the formula :Y--A--CO--R.sup.1are inhibitors of serine proteases and carbonic anhydrase isozymes. They are useful in the treatment of hyper-coagulation disease and ocular diseases such as glaucoma.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 8, 1997
    Assignee: Pharmacopeia, Inc.
    Inventors: John J. Baldwin, Michael H. J. Ohlmeyer, Ian Henderson
  • Patent number: 5595990
    Abstract: Benzo-(1,5)-diazepine derivatives with an amide or urea function in the 3-position are useful in the treatment of arrhythmia.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: January 21, 1997
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David A. Claremon, Jason M. Elliott, Nigel Liverton, David C. Remy, Harold G. Selnick