Patents by Inventor John J. Dunn
John J. Dunn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150010424Abstract: An austenitic stainless steel composition having low nickel and molybdenum and exhibiting high corrosion resistance and good formability. The austenitic stainless steel includes, in weight %, up to 0.20 C, 2.0-6.0 Mn, up to 2.0 Si, 16.0-23.0 Cr, 5.0-7.0 Ni, up to 3.0 Mo, up to 3.0 Cu, 0.1-0.35 N, up to 4.0 W, up to 0.01 B, up to 1.0 Co, iron and impurities. The austenitic stainless steel has a ferrite number less than 11 and an MD30 value less than ?10° C.Type: ApplicationFiled: September 26, 2014Publication date: January 8, 2015Inventors: David S. Bergstrom, James M. Rakowski, Charles P. Stinner, John J. Dunn, John F. Grubb
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Publication number: 20140369882Abstract: An austenitic stainless steel having low nickel and molybdenum and exhibiting comparable corrosion resistance and formability properties to higher nickel and molybdenum alloys comprises, in weight %, up to 0.20 C, 2.0-9.0 Mn, up to 2.0 Si, 16.0-23.0 Cr, 1.0-5.0 Ni, up to 3.0 Mo, up to 3.0 Cu, 0.1-0.35 N, up to 4.0 W, up to 0.01 B, up to 1.0 Co, iron and impurities, the steel having a ferrite number of less than 10 and a MD30 value of less than 20° C.Type: ApplicationFiled: August 11, 2014Publication date: December 18, 2014Inventors: David S. Bergstrom, James M. Rakowski, Charles P. Stinner, John J. Dunn, John F. Grubb
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Patent number: 8877121Abstract: An austenitic stainless steel composition having low nickel and molybdenum and exhibiting high corrosion resistance and good formability. The austenitic stainless steel includes, in weight %, up to 0.20 C, 2.0-6.0 Mn, up to 2.0 Si, 16.0-23.0 Cr, 5.0-7.0 Ni, up to 3.0 Mo, up to 3.0 Cu, 0.1-0.35 N, up to 4.0 W, up to 0.01 B, up to 1.0 Co, iron and impurities. The austenitic stainless steel has a ferrite number less than 11 and an MD30 value less than ?10° C.Type: GrantFiled: February 26, 2008Date of Patent: November 4, 2014Assignee: ATI Properties, Inc.Inventors: David S. Bergstrom, James M. Rakowski, Charles P. Stinner, John J. Dunn, John F. Grubb
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Patent number: 8858872Abstract: An austenitic stainless steel having low nickel and molybdenum and exhibiting comparable corrosion resistance and formability properties to higher nickel and molybdenum alloys comprises, in weight %, up to 0.20 C, 2.0-9.0 Mn, up to 2.0 Si, 16.0-23.0 Cr, 1.0-5.0 Ni, up to 3.0 Mo, up to 3.0 Cu, 0.1-0.35 N, up to 4.0 W, up to 0.01 B, up to 1.0 Co, iron and impurities, the steel having a ferrite number of less than 10 and a MD30 value of less than 20° C.Type: GrantFiled: October 15, 2012Date of Patent: October 14, 2014Assignee: ATI Properties, Inc.Inventors: David S. Bergstrom, James M. Rakowski, Charles P Stinner, John J. Dunn, John F. Grubb
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Publication number: 20140141030Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.Type: ApplicationFiled: November 12, 2013Publication date: May 22, 2014Applicants: BAXTER INTERNATIONAL INC., Brookhaven Science Associates, LLC, Research Foundation of the State University of New York, BAXTER HEALTHCARE SAInventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
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Patent number: 8728733Abstract: Disclosed is a method for analyzing the organismic complexity of a sample through analysis of the nucleic acid in the sample. In the disclosed method, through a series of steps, including digestion with a type II restriction enzyme, ligation of capture adapters and linkers and digestion with a type IIS restriction enzyme, genome signature tags are produced. The sequences of a statistically significant number of the signature tags are determined and the sequences are used to identify and quantify the organisms in the sample. Various embodiments of the invention described herein include methods for using single point genome signature tags to analyze the related families present in a sample, methods for analyzing sequences associated with hyper- and hypo-methylated CpG islands, methods for visualizing organismic complexity change in a sampling location over time and methods for generating the genome signature tag profile of a sample of fragmented DNA.Type: GrantFiled: October 29, 2007Date of Patent: May 20, 2014Assignee: Brookhaven Science Associates, LLCInventor: John J. Dunn
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Patent number: 8680236Abstract: Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.Type: GrantFiled: November 19, 2008Date of Patent: March 25, 2014Assignees: Brookhaven Sciences Associates, LLC, University of Rochester, Research Foundation of the State University of New YorkInventors: Benjamin J. Luft, John J. Dunn, Shohei Koide, Catherine L. Lawson
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Publication number: 20140030285Abstract: Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.Type: ApplicationFiled: July 17, 2013Publication date: January 30, 2014Applicants: Brookhaven Sciences Associates, LLC, Research Foundation of the State University of New York, University of RochesterInventors: Benjamin J. Luft, John J. Dunn, Shohei Koide, Catherine L. Lawson
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Patent number: 8623376Abstract: The invention relates to the development of chimeric OpsA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.Type: GrantFiled: May 13, 2011Date of Patent: January 7, 2014Assignees: Baxter International Inc., Baxter Healthcare S.A., Research Foundation for the State University of New York, Brookhaven Science Associates, LLCInventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
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Patent number: 8592185Abstract: The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a recombinant, full length and substantially pure McrA protein (rMcrA) for binding and isolation of DNA fragments containing the sequence 5?-CMeCpGG-3?. Methods for making and using the rMcrA protein, and derivatives thereof are provided.Type: GrantFiled: August 3, 2012Date of Patent: November 26, 2013Assignee: Brookhaven Science Associates, LLCInventor: John J. Dunn
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Publication number: 20130156628Abstract: An austenitic alloy may generally comprise, in weight percentages based on total alloy weight: up to 0.2 carbon; up to 20 manganese; 0.1 to 1.0 silicon; 14.0 to 28.0 chromium; 15.0 to 38.0 nickel; 2.0 to 9.0 molybdenum; 0.1 to 3.0 copper; 0.08 to 0.9 nitrogen; 0.1 to 5.0 tungsten; 0.5 to 5.0 cobalt; up to 1.0 titanium; up to 0.05 boron; up to 0.05 phosphorous; up to 0.05 sulfur; iron; and incidental impurities.Type: ApplicationFiled: December 20, 2011Publication date: June 20, 2013Applicant: ATI PROPERTIES, INC.Inventors: Robin M. Forbes Jones, C. Kevin Evans, Henry E. Lippard, Adrian R. Mills, John C. Riley, John J. Dunn
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Publication number: 20130040343Abstract: The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a recombinant, full length and substantially pure McrA protein (rMcrA) for binding and isolation of DNA fragments containing the sequence 5?-CMeCpGG-3?. Methods for making and using the rMcrA protein, and derivatives thereof are provided.Type: ApplicationFiled: August 3, 2012Publication date: February 14, 2013Applicant: Brookhaven Science Associates, LLCInventor: John J. Dunn
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Patent number: 8361746Abstract: The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a recombinant, full length and substantially pure McrA protein (rMcrA) for binding and isolation of DNA fragments containing the sequence 5?-CMeCpGG-3?. Methods for making and using the rMcrA protein, and derivatives thereof are provided.Type: GrantFiled: July 22, 2009Date of Patent: January 29, 2013Assignee: Brookhaven Science Associates, LLCInventor: John J. Dunn
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Patent number: 8337748Abstract: An austenitic stainless steel composition including relatively low nickel and molybdenum levels, and exhibiting corrosion resistance, resistance to elevated temperature deformation, and formability properties comparable to certain alloys including higher nickel and molybdenum levels. Embodiments of the austenitic stainless steel include, in weight %, up to 0.20 C, 2.0-9.0 Mn, up to 2.0 Si, 16.0-23.0 Cr, 1.0-7.0 Ni, up to 3.0 Mo, up to 3.0 Cu, 0.05-0.35 N, up to 4.0 W, (7.5(% C))?(Nb+Ti+V+Ta+Zr)?1.5, up to 0.01 B, up to 1.0 Co, iron and impurities. Additionally, embodiments of the steel may include 0.5?(Mo+W/2)?5.0 and/or 1.0?(Ni+Co)?8.0.Type: GrantFiled: February 20, 2008Date of Patent: December 25, 2012Assignee: ATI Properties, Inc.Inventors: James M. Rakowski, David S. Bergstrom, Charles P. Stinner, John J. Dunn, John F. Grubb
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Patent number: 8313691Abstract: An austenitic stainless steel having low nickel and molybdenum and exhibiting comparable corrosion resistance and formability properties to higher nickel and molybdenum alloys comprises, in weight %, up to 0.20 C, 2.0-9.0 Mn, up to 2.0 Si, 16.0-23.0 Cr, 1.0-5.0 Ni, up to 3.0 Mo, up to 3.0 Cu, 0.1-0.35 N, up to 4.0 W, up to 0.01 B, up to 1.0 Co, iron and impurities, the steel having a ferrite number of less than 10 and a MD30 value of less than 20° C.Type: GrantFiled: February 26, 2008Date of Patent: November 20, 2012Assignee: ATI Properties, Inc.Inventors: David S. Bergstrom, James M. Rakowski, Charles P. Stinner, John J. Dunn, John F. Grubb
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Patent number: 8263742Abstract: The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a recombinant, full length and substantially pure McrA protein (rMcrA) for binding and isolation of DNA fragments containing the sequence 5?-CMeCpGG-3?. Methods for making and using the rMcrA protein, and derivatives thereof are provided.Type: GrantFiled: April 12, 2011Date of Patent: September 11, 2012Assignee: Brookhaven Science Associates, LLCInventor: John J. Dunn
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Publication number: 20120219942Abstract: The invention provides methods for using the rMcrA protein, and derivatives thereof, for direct or semi-direct determination of the methylation status of CpG dinucleotides in methyl-CpG island sequences of interest.Type: ApplicationFiled: December 13, 2011Publication date: August 30, 2012Applicant: Brookhaven Science Associates, LLCInventors: John J. Dunn, Eli Hatchwell
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Publication number: 20120020973Abstract: The invention relates to the development of chimeric OspA molecules for use in a new Lyme vaccine. More specifically, the chimeric OspA molecules comprise the proximal portion from one OspA serotype, together with the distal portion from another OspA serotype, while retaining antigenic properties of both of the parent polypeptides. The chimeric OspA molecules are delivered alone or in combination to provide protection against a variety of Borrelia genospecies. The invention also provides methods for administering the chimeric OspA molecules to a subject in the prevention and treatment of Lyme disease or borreliosis.Type: ApplicationFiled: May 13, 2011Publication date: January 26, 2012Applicants: BAXTER INTERNATIONAL INC., Brookhaven Sciences Associates, LLC, Research Foundation of the State University of New York, BAXTER HEALTHCARE S.A.Inventors: Brian A. Crowe, Ian Livey, Maria O'Rourke, Michael Schwendinger, John J. Dunn, Benjamin J. Luft
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Publication number: 20110245465Abstract: The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a recombinant, full length and substantially pure McrA protein (rMcrA) for binding and isolation of DNA fragments containing the sequence 5?-CMeCpGG-3?. Methods for making and using the rMcrA protein, and derivatives thereof are provided.Type: ApplicationFiled: April 12, 2011Publication date: October 6, 2011Applicant: Brookhaven Science Associates, LLCInventor: John J. Dunn
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Publication number: 20100081174Abstract: The invention provides methods for enriching methyl-CpG sequences from a DNA sample. The method makes use of conversion of cytosine residues to uracil under conditions in which methyl-cytosine residues are preserved. Additional methods of the invention enable to preservation of the context of me-CpG dinucleotides. The invention also provides a recombinant, full length and substantially pure McrA protein (rMcrA) for binding and isolation of DNA fragments containing the sequence 5?-CMeCpGG-3?. Methods for making and using the rMcrA protein, and derivatives thereof are provided.Type: ApplicationFiled: July 22, 2009Publication date: April 1, 2010Applicant: Brookhaven Science Associates, LLCInventor: John J. Dunn