Patents by Inventor John James Zaunders
John James Zaunders has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9291623Abstract: The present invention relates to methods and kits for identifying, quantifying and isolating regulatory T cells, to methods and kits for diagnosing or monitoring autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer, cancer treatment and/or organ transplantation based on regulatory T cell quantity, to methods and kits for predicting responses to therapy for autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer and/or organ transplantation based on regulatory T cell quantity, and to methods and kits for therapy using isolated regulatory T cells.Type: GrantFiled: April 15, 2011Date of Patent: March 22, 2016Assignee: CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGYInventors: Barbara Denise Fazekas De St Groth, Anthony Dominic Kelleher, Alan Lee Landay, Sarah Christina Sasson, Nabila Seddiki, John James Zaunders
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Patent number: 8975069Abstract: A method of identifying an antigen-specific regulatory T cell (Treg) from a subject is discussed wherein the method comprises quantitatively or qualitatively detecting co-expression of each of cell markers CD4, CD25 and CD134, or alternatively, each of cell markers CD8, CD25 and CD137, as well as one or more cell markers selected from the group of Treg cell markers consisting of CD39, CD73, CD127, CTLA-4 and Foxp3 on a cell in a suitable lymphocyte-containing sample from the subject in response to exposure to a target antigen. Also discussed are methods of isolating and expanding the identified antigen-specific Treg population, which may permit antigen-specific Treg cell therapy.Type: GrantFiled: September 22, 2008Date of Patent: March 10, 2015Assignee: St. Vincent's Hospital Sydney LimitedInventors: Anthony Dominic Kelleher, John James Zaunders, Nabila Seddiki
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Publication number: 20140067275Abstract: Disclosed is a method of cluster analysis of a data set of multidimensional observations. The method comprises: determining a set of quasi-optimal binwidths for the data set; partitioning, for a current binwidth in the set of quasi-optimal binwidths, the data set into a plurality of bins of width equal to the current binwidth; determining the number of modes of the partitioned data set for the current binwidth; and repeating the partitioning and determining the number of modes for each binwidth in the set of quasi-optimal binwidths. The number of clusters in the data set is the largest determined number of modes over the set of quasi-optimal binwidths.Type: ApplicationFiled: March 9, 2012Publication date: March 6, 2014Inventors: Junmei Jing, Inge Koch, John James Zaunders
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Publication number: 20110318749Abstract: The present invention relates to methods and kits for identifying, quantifying and isolating regulatory T cells, to methods and kits for diagnosing or monitoring autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer, cancer treatment and/or organ transplantation based on regulatory T cell quantity, to methods and kits for predicting responses to therapy for autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer and/or organ transplantation based on regulatory T cell quantity, and to methods and kits for therapy using isolated regulatory T cells.Type: ApplicationFiled: April 15, 2011Publication date: December 29, 2011Applicant: CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGYInventors: Barbara Denise FAZEKAS DE ST GROTH, Anthony Dominic Kelleher, Alan Lee Landay, Sarah Christina Sasson, Nabila Seddiki, John James Zaunders
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Patent number: 8030005Abstract: The present invention comprises a method for the quantitative or qualitative detection of antigen-specific CD4+ T cells and/or CD8+ T cells in a subject, said method comprising quantitatively or qualitatively detecting the expression of cell surface marker CD25 and one or more of cell surface markers CD134 and CD137 in a suitable lymphocyte-containing sample from said subject in response to exposure to an antigen. A method for determining the immunocompetence of a subject and a method for isolating antigen-specific CD4+ and/or CD8+ T cells is also disclosed.Type: GrantFiled: March 20, 2007Date of Patent: October 4, 2011Assignee: St. Vincent's Hospital Sydney LimitedInventors: Anthony Dominic Kelleher, John James Zaunders
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Publication number: 20110229448Abstract: A method of identifying an antigen-specific regulatory T cell (Treg) from a subject is discussed wherein the method comprises quantitatively or qualitatively detecting co-expression of each of cell markers CD4, CD25 and CD134, or alternatively, N each of cell markers CD8, CD25 and CD137, as well as one or more cell markers selected from the group of Treg cell markers consisting of CD39, CD73, CD127, CTLA-4 and Foxp3 on a cell in a suitable lymphocyte-containing sample from the subject in response to exposure to a target antigen. Also discussed are methods of isolating and expanding the identified antigen-specific Treg population, which may permit antigen-specific Treg cell therapy.Type: ApplicationFiled: September 22, 2008Publication date: September 22, 2011Applicants: ST VINCENT'S HOSPITAL SYDNEY LIMITED, NEWSOUTH INNOVATIONS PTY LIMITEDInventors: Anthony Dominic Kelleher, John James Zaunders, Nabila Seddiki
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Patent number: 7947464Abstract: The present invention relates to methods and kits for identifying, quantifying and isolating regulatory T cells, to methods and kits for diagnosing or monitoring autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer, cancer treatment and/or organ transplantation based on regulatory T cell quantity, to methods and kits for predicting responses to therapy for autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer and/or organ transplantation based on regulatory T cell quantity, and to methods and kits for therapy using isolated regulatory T cells.Type: GrantFiled: July 31, 2006Date of Patent: May 24, 2011Assignee: Centenary Institute of Cancer Medicine and Cell BiologyInventors: Barbara Denise Fazekas De St Groth, Anthony Dominic Kelleher, Alan Lee Landay, Sarah Christina Sasson, Nabila Seddiki, John James Zaunders
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Publication number: 20100028865Abstract: The present invention relates to methods and kits for identifying, quantifying and isolating regulatory T cells, to methods and kits for diagnosing or monitoring autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer, cancer treatment and/or organ transplantation based on regulatory T cell quantity, to methods and kits for predicting responses to therapy for autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer and/or organ transplantation based on regulatory T cell quantity, and to methods and kits for therapy using isolated regulatory T cells.Type: ApplicationFiled: July 31, 2006Publication date: February 4, 2010Inventors: Barbara Denise Fazekas De St Groth, Anthony Dominic Kelleher, Alan Lee Landay, Sarah Christina Sasson, Nabila Seddiki, John James Zaunders
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Publication number: 20090221005Abstract: The present invention comprises a method for the quantitative or qualitative detection of antigen-specific CD4+ T cells and/or CD8+ T cells in a subject, said method comprising quantitatively or qualitatively detecting the expression of cell surface marker CD25 and one or more of cell surface markers CD134 and CD137 in a suitable lymphocyte-containing sample from said subject in response to exposure to an antigen. A method for determining the immunocompetence of a subject and a method for isolating antigen-specific CD4+ and/or CD8+ T cells is also disclosed.Type: ApplicationFiled: March 20, 2007Publication date: September 3, 2009Applicant: ST VINCENT'S HOSPITAL SYDNEY LIMITEDInventors: Anthony Dominic Kelleher, John James Zaunders